Skip to main content

Arterial Diseases in Infancy

  • Chapter
Developmental Neuropathology
  • 186 Accesses

Abstract

The residual cavities of infarcts from occlusive arterial disease in infancy or childhood differ from those of porencephaly, hydranencephaly or multicystic encephalopathy described in Chap. 3. Porencephalies and hydranencephalies develop during fetal life, often bilateral and in middle cerebral artery distribution. They cause smooth-walled, full thickness defects, often with developmental anomalies in the adjacent cortex. Cerebral infarcts during the peri- or postnatal periods are more similar to those in the adult brain. Their size and distribution is variable. Small infarcts have random distribution, larger ones are usually unilateral, corresponding to major cerebral arteries. They cause circumscribed defects with shaggy walls (Fig. 10.1). Occlusive vascular disease is usually identified upon thorough search.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Almeida GM, Pindaro J, Plese P, Bianco E, Shibata MK (1977) Intracranial arterial aneurysms in infancy and childhood. Childs Brain 3:193–199

    PubMed  CAS  Google Scholar 

  • Amacher AL, Drake CG (1975) Cerebral artery aneurysms in infancy, childhood and adolescence. Childs Brain 1:72–80

    PubMed  CAS  Google Scholar 

  • Amit M, Camfield PR (1980) Neonatal polycythemia causing multiple cerebral infarcts. Arch Neurol 37:109–110

    PubMed  CAS  Google Scholar 

  • Anderson KA, Burbach JA, Fenton LJ, Jaqua RA, Barlow JF (1985) Idiopathic arterial calcification of infancy in newborn siblings with unusual light and electron microscopic manifestations. Arch Pathol Lab Med 109:838–842

    PubMed  CAS  Google Scholar 

  • Arai H, Sugiyama Y, Kawakami S, Miyazawa N (1972) Multiple intracranial aneurysms and vascular malformations in an infant. Case report. J Neurosurg 37:357–360

    Article  PubMed  CAS  Google Scholar 

  • Banker BQ (1961) Cerebral vascular disease in infancy and childhood. 1. Occlusive vascular diseases. J Neuropathol Exp Neurol 20:127–140

    Article  PubMed  CAS  Google Scholar 

  • Barmada MA, Moossy J, Shuman RM (1979) Cerebral infarcts with arterial occlusion in neonates. Ann Neurol 6:495–502

    Article  PubMed  CAS  Google Scholar 

  • Benda CE (1945) The late effects of cerebral birth injuries. Medicine 24:71–110

    Article  Google Scholar 

  • Benda CE (1952) Structural cerebral histopathology of mental deficiencies. Proceedings of the First International Congress of Neuropathology, Turin, vol 2. Rosenberg & Sellier, Turin, pp 7–50

    Google Scholar 

  • Benyo RB, Perrin EV(1968) Periarteritis nodosa in infancy. Am J Dis Child 116:539–544

    PubMed  CAS  Google Scholar 

  • Bertrand I, Bargeton E (1955) Lésions vasculaires dans l’hémiplégie cérébrale infantile. Proceedings of the Second International Congress of Neuropathology, London, Part II. Excerpta Medica, Amsterdam, pp 519–522

    Google Scholar 

  • Bigelow NH (1953) The association of polycystic kidneys with intracranial aneurysms and other related disorders. Am J Med Sci 225:485–494

    Article  PubMed  CAS  Google Scholar 

  • Bragin MA, Cherkasov AP (1979) On the morphogenesis of fibrous muscular dysplasia of renal arteries (an ultrastructural study). Arkh Patol 41:46–52

    PubMed  CAS  Google Scholar 

  • Buck RC (1961) Intimai thickening after ligature of arteries. An electron-microscopic study. Circ Res 9:418–426

    Google Scholar 

  • Campbell PE (1965) Vascular abnormalities following maternal rubella. Br Heart J 27:134–138

    Article  PubMed  CAS  Google Scholar 

  • Carson NAJ, Dent CE, Field CMB, Gaull GE (1965) Homocystinuria. Clinical and pathological review of ten cases. J Pediatr 66:565–583

    Article  PubMed  CAS  Google Scholar 

  • Clark RM, Linell EA (1954) Case report: prenatal occlusion of the internal carotid artery. J Neurol Neurosurg Psychiatry 17:295–297

    Article  PubMed  CAS  Google Scholar 

  • Coakham HB, Duchen LW, Scaravilli F (1979) Moya-moya disease: clinical and pathological report of a case with associated myopathy. J Neurol Neurosurg Psychiatry 42:289–297

    Article  PubMed  CAS  Google Scholar 

  • Cochrane WA, Bowden DH (1954) Calcification of the arteries in infancy and childhood. Pediatrics 14:222–231

    PubMed  CAS  Google Scholar 

  • Cocker J, George SW, Yates PO (1965) Perinatal occlusion of the middle cerebral artery. Dev Med Child Neurol 7:235–243

    Article  PubMed  CAS  Google Scholar 

  • Crome L (1958) Multilocular cystic encephalopathy of infants. J Neurol Neurosurg Psychiatry 21:146–152

    Article  PubMed  CAS  Google Scholar 

  • Cseh I von (1937) Multiple Cystenbildung im Gehirn. Über einen nichtentzündlichen Proliferationsvorgang in der Intima der pialen Gefässe. Frankfurt Z Pathol 50:534–546

    Google Scholar 

  • Davie JC, Coxe W (1967) Occlusive disease of the carotid artery in children. Carotid thrombectomy with recovery in a 2-year-old boy. Arch Neurol 17:313–323

    PubMed  CAS  Google Scholar 

  • Duffy PE, Portnoy B, Mauro J, Wehrle PF (1957) Acute infantile hemiplegia secondary to spontaneous carotid thrombosis. Neurology 7:664–666

    PubMed  CAS  Google Scholar 

  • Echenne B, Gras M, Astruc J, Castan P, Brunei D (1983) Vertebro-basilar arterial occlusion in childhood. Report of a case and review of the literature. Brain Dev 5:577–581

    PubMed  CAS  Google Scholar 

  • Eggers C, Schmitt HP, Fahr K (1973) Cerebrale Manifestationen der Leukämie im Säuglingsalter. Neuropädiatrie 4:458–472

    Article  PubMed  CAS  Google Scholar 

  • Eicke W-J (1947) Gefäßveränderungen bei Meningitis und ihre Bedeutung für die Pathogenese frühkindlicher Hirnschäden. Virchows Arch [A] 314:88–124

    CAS  Google Scholar 

  • Esterly JR, Oppenheimer EH (1967) Vascular lesions in infants with congenital rubella. Circulation 36:544–554

    PubMed  CAS  Google Scholar 

  • Fager DB, Bigler JA, Simonds JP (1951) Polyarteritis nodosa in infancy and childhood. J Pediatr 39:65–79

    Article  PubMed  CAS  Google Scholar 

  • Fairburn B (1957) Thrombosis of internal carotid artery after soft-palate injury. Br Med J 2:750–751

    Article  PubMed  CAS  Google Scholar 

  • Ferry PC, Kerber C, Peterson D, Gallo AA Jr (1974) Arteriectasis, subarachnoid hemorrhage in a three-month-old infant. Neurology 24:494–500

    PubMed  CAS  Google Scholar 

  • Field MH (1946) Medial calcification of arteries of infants. Arch Pathol 42:607–618

    CAS  Google Scholar 

  • Ford FR, Schaffer AJ (1927) The etiology of infantile acquired hemiplegia. Arch Neurol Psychiatry 18:323–347

    Google Scholar 

  • Forster FM, Alpers BJ (1943) Aneurysm of circle of Willis associated with congenital polycystic disease of the kidneys. Arch Neurol Psychiatry 50:669–676

    Google Scholar 

  • Fortuin NJ, Morrow AG, Roberts WC (1971) Late vascular manifestations of the rubella syndrome. A roentgenographic-pathologic study. Am J Med 51:134–140

    Article  PubMed  CAS  Google Scholar 

  • Gabilan J-C, Habib R, Lajouanine P, Canet J, Riahi M (1966) L’artériopathie calcifiante infantile. Arch Fr Pédiatr 23:179–197

    PubMed  CAS  Google Scholar 

  • Garcia-Chavez C, Moossy J (1965) Cerebral artery aneurysm in infancy: association with agenesis of the corpus callosum. J Neuropathol Exp Neurol 24:492–501

    Article  Google Scholar 

  • Gibson JB, Carson NAJ, Neill DW (1964) Pathological findings in homocystinuria. J Clin Pathol 17:427–437

    Article  PubMed  CAS  Google Scholar 

  • Goldstein SL, Burgess JP (1958) Spontaneous thrombosis of the internal carotid artery in a seven-year-old child. Am J Dis Child 95:538–540

    CAS  Google Scholar 

  • Gross RE (1945) Arterial embolism and thrombosis in infancy. Am J Dis Child 70:61–73

    Google Scholar 

  • Hallervorden J (1937) Das Geburtstrauma als Ursache der Entwicklungshemmung im Kindesalter. Med Klin 33:1224–1229

    Google Scholar 

  • Harvey FH, Alvord EC Jr (1972) Juvenile cerebral arteriosclerosis and other cerebral arteriopathies of childhood. Six autopsied cases. Acta Neurol Scand 48:479–509

    Article  PubMed  CAS  Google Scholar 

  • Hegedüs K (1985) Reticular fiber deficiency in the intracranial arteries of patients with dissecting aneurysm and review of the possible pathogenesis of previously reported cases. Eur Arch Psychiatr Neurol Sci 235:102–106

    Article  Google Scholar 

  • Hilal SK, Solomon GE, Gold AP, Carter S (1971) Primary cerebral arterial occlusive disease in children. Part I: Acute acquired hemiplegia. Part II: Neurocutaneous syndromes. Radiology 99:71–86; 87–94

    PubMed  CAS  Google Scholar 

  • Holm V (1967) Arteriopathia calcificans infantum. Acta Paediatr Scand 56:537–540

    Article  PubMed  CAS  Google Scholar 

  • Hungerford DG, Marzluff JM, Kempe LG, Powers JM (1981) Cerebral arterial aneurysm in a neonate. Neuroradiology 21:107–110

    Article  PubMed  CAS  Google Scholar 

  • Ivemark BI, Lagergren C, Ljungqvist A (1962) Generalized arterial calcification associated with hydramnios in two stillborn infants. Acta Paediatr Scand 51, Suppl 135:103–110

    Google Scholar 

  • Jacob JC, Maroun FB, Heneghan WD, House AM (1970) Uncommon cerebrovascular lesions in children. Dev Med Child Neurol 12:446–453

    Article  PubMed  CAS  Google Scholar 

  • Janssen W (1957) Zur Frage der kindlichen Arteriosklerose, besonders der Herzkranzgefäße. Monatsschr Kinderheilkd 105:361–366

    PubMed  CAS  Google Scholar 

  • Johnsen SD, Okamoto G, Kooiker J (1977) Fusiform basilar artery aneurysm in a child. Neurology 27:334–336

    PubMed  CAS  Google Scholar 

  • Juba A (1936) Über einen zellig-fibrösen, nicht entzündeten Obliterationsvorgang der meningealen Arterien im Säuglingsalter. Arch Psychiatr Nervenkr 104:663–677

    Article  Google Scholar 

  • Lange-Cosack H (1944) Die Hydranencephalie (Blasenhirn) als Sonderform der Großhirnlosigkeit. I. Anatomischer Teil, II. Klinischer Teil. Arch Psychiatr Nervenkr 117:1–51; 595–640

    Article  Google Scholar 

  • Levy SR, Abroms IF, Marshall PC, Rosquete EE (1985) Seizures and cerebral infarction in the full-term newborn. Ann Neurol 17:366–370

    Article  PubMed  CAS  Google Scholar 

  • Little JR, Larkins MV, Lüders H, Hahn JF, Erenberg G (1986) Fusiform basilar artery aneurysm in a 33-month-old child. Neurosurgery 19:631–634

    Article  PubMed  CAS  Google Scholar 

  • Martin FP, Lukeman JM, Ranson RF, Geppert LJ (1954) Mucormycosis of the central nervous system associated with thrombosis of the internal carotid artery. J Pediatr 44:437–442

    Article  PubMed  CAS  Google Scholar 

  • McCully KS (1969) Vascular pathology of homocysteinemia: implications for the pathogenesis of arterioclerosis. Am J Pathol 56:111–128

    PubMed  CAS  Google Scholar 

  • Mehrotra RML (1953) An experimental study of the changes which occur in ligated arteries and veins. J Pathol Bacteriol 65:307–313

    Article  PubMed  CAS  Google Scholar 

  • Menser MA, Dorman DC, Reye RDK, Reid RR (1966) Renal-artery stenosis in the rubella syndrome. Lancet 1:790–792

    Article  PubMed  CAS  Google Scholar 

  • Ment LR, Duncan CC, Ehrenkranz RA (1984) Perinatal cerebral infarction. Ann Neurol 16:559–568

    Article  PubMed  CAS  Google Scholar 

  • Mettinger KL (1982) Fibromuscular dysplasia and the brain. II. Current concept of the disease. Stroke 13:53–58

    Article  PubMed  CAS  Google Scholar 

  • Meyer J-E (1951) Über Gefäßveränderungen beim fetalen und frühkindlichen Cerebralschaden. Arch Psychiatr Nervenkr 186:437–455

    Article  CAS  Google Scholar 

  • Moran JJ, Becker SM (1959) Idiopathic arterial calcification of infancy. Report of 2 cases occurring in siblings, and review of the literature. Am J Clin Pathol 31:517–529

    PubMed  CAS  Google Scholar 

  • Moran JJ, Steiner GC (1962) Idiopathic arterial calcification in a 5-year-old child. Am J Clin Pathol 37:521–526

    PubMed  CAS  Google Scholar 

  • Nishioka H (1966) Report of the cooperative study of intracranial aneurysms and subarachnoid hemorrhage. Section 7, Part 1. Evaluation of the conservative management of ruptured intracranial aneurysms. J Neurosurg 25:574–592

    Article  PubMed  CAS  Google Scholar 

  • Norman RM, Urich H (1957) Dissecting aneurysm of the middle cerebral artery as a cause of acute infantile hemiplegia. J Pathol Bacteriol 73:580–582

    Article  Google Scholar 

  • Norman RM, Urich H, McMenemey WH (1957) Vascular mechanismus of birth injury. Brain 80:49–58

    Article  PubMed  CAS  Google Scholar 

  • Oka K, Yamashita M, Sodashima S, Tanaka K (1981) Cerebral haemorrhage in moyamoya disease at autopsy. Virchows Arch [A] 392:247–261

    Article  CAS  Google Scholar 

  • Pascual-Castroviejo I, Pascual-Pascual JI, Mulas F, Roche MC, Tendero A (1977) Bilateral obstruction of the vertebral arteries in a three-year-old child. Dev Med Child Neurol 19:232–238

    Article  PubMed  CAS  Google Scholar 

  • Peebles Brown RA (1951) Polycystic disease of the kidneys and intracranial aneurysms. The etiology and interrelationship of these conditions; review of recent literature and report of seven cases in which both conditions coexisted. Glasgow Med J 32:333–348

    Google Scholar 

  • Price RA, Vawter GF (1972) Arterial fibromuscular dysplasia in infancy and childhood. Arch Pathol 93:419–426

    PubMed  CAS  Google Scholar 

  • Prior JT, Bergstrom VW (1948) Generalized arterial calcification in infants. Am J Dis Child 76:91–101

    PubMed  CAS  Google Scholar 

  • Ringel SP, Harrison SH, Norenberg MD, Austin JH (1977) Fibromuscular dysplasia: multiple “spontaneous” dissecting aneurysms of the major cervical arteries. Ann Neurol 1:301–304

    Article  PubMed  CAS  Google Scholar 

  • Romanul FCA, Abramowicz A (1964) Changes in brain and pial vessels in arterial border zones. Arch Neurol 11:40–65

    PubMed  CAS  Google Scholar 

  • Rorke LB, Spiro AJ (1967) Cerebral lesions in congenital rubella syndrome. J Pediatr 70:243–255

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal IM, Bronstein IP, Dallenbach FD, Pruzansky S, Rosenwald AK (1956) Progeria. Report of a case with cephalometric roentgenograms and abnormally high concentrations of lipoproteins in the serum. Pediatrics 18:565–577

    PubMed  Google Scholar 

  • Sato M, Kohama A, Fukuda A, Tanaka S, Fukunaga M, Morita R (1985) Moyamoya-like diseases associated with ventricular hemorrhages: report of three cases. Neurosurgery 17:260–266

    Article  PubMed  CAS  Google Scholar 

  • Siegmund H (1923) Geburtsschädigungen des kindlichen Gehirns und ihre Folgen. Münch Med Wochenschr 70:137–139

    Google Scholar 

  • Singer DB, Rudolph AJ, Rosenberg HS, Raels WE, Boniuk M (1967) Pathology of the congenital rubella syndrome. J Pediatr 71:665–675

    Article  PubMed  CAS  Google Scholar 

  • Søgaard I, Jørgensen J (1975) Familial occurrence of bilateral intracranial occlusion of the internal carotid arteries (moya moya). Acta Neurochir 31:245–252

    Article  Google Scholar 

  • Sokoloff A (1893) Ueber die Bedingungen der Bindegewebsneubildung in der Intima doppelt unterbundener Arterien. Beitr Pathol Anat 14:11–32

    Google Scholar 

  • Spudis EV, Scharyj M, Alexander E, Martin JF (1962) Dissecting aneurysms in the neck and head. Neurology 12:867–875

    PubMed  CAS  Google Scholar 

  • Stryker WA (1946) Arterial calcification in infancy with special reference to the coronary arteries. Am J Pathol 22:1007–1031

    Google Scholar 

  • Takeuchi K (1961) Occlusive disease of the carotid artery. Adv Neurol Sci (Tokyo) 5:511–543 (in Japanese)

    Google Scholar 

  • Thoma R (1883) Ueber die Abhängigkeit der Bindegewebsneubildung in der Arterienintima von den mechanischen Bedingungen des Blutumlaufes. IL Mittheilung: Das Verhalten der Arterien in Amputationsstümpfen. Arch Pathol Anat 93:443–505

    Article  Google Scholar 

  • Thoma R (1884) Ueber die Abhängigkeit der Bindegewebsneubildung in der Arterienintima von den mechanischen Bedingungen des Blutumlaufes. Arch Pathol Anat 95:294–336

    Article  Google Scholar 

  • White HH, Rowland LP, Araki S, Thompson HL, Cowen D (1965) Homocystinuria. Arch Neurol 13:455–470

    PubMed  CAS  Google Scholar 

  • Williams G (1956) Experimental studies in arterial ligation. J Pathol Bacteriol 72:569–574

    Article  Google Scholar 

  • Wisoff HS, Rothballer AB (1961) Cerebral arterial thrombosis in children. Arch Neurol 4:258–267

    PubMed  CAS  Google Scholar 

  • Witzleben CL (1970) Idiopathic infantile arterial calcification — a misnomer? Am J Cardiol 26:305–309

    Article  PubMed  CAS  Google Scholar 

  • Wolman L (1959) Cerebral dissecting aneurysms. Brain 82:276–291

    Article  PubMed  CAS  Google Scholar 

  • Wright I (1963) The microscopical appearances of human peripheral arteries during growth and aging. J Clin Pathol 16:499–522

    Article  PubMed  CAS  Google Scholar 

  • Yates PO (1959) Birth trauma to the vertebral arteries. Arch Dis Child 34:436–441

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Friede, R.L. (1989). Arterial Diseases in Infancy. In: Developmental Neuropathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73697-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73697-1_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73699-5

  • Online ISBN: 978-3-642-73697-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics