Advertisement

Long-Term Therapy of Acromegaly with SMS 201–995 (Sandostatin®)

  • D. Killinger
  • J. Gonzalez
Conference paper

Abstract

SMS 201–995 (Sandostatin®), a long-acting analogue of somatostatin, has been shown to be effective in lowering growth hormone (GH) levels in patients with acromegaly [1, 2]. Suppression of GH levels persists for 6 to 8 h and a treatment schedule of two or three daily injections is required to maintain optimum suppression. In the present study, 2 patients who had been unsuccessfully treated by surgery or surgery and pituitary irradiation were treated with Sandostatin for 12 to 18 months and clinical and laboratory parameters were followed to determine the efficacy of treatment.

Keywords

Growth Hormone Prolactin Level Growth Hormone Level Proton Beam Irradiation Pituitary Irradiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ch’ng JLC, Sandler LM, Kraenzlin ME, Burrin JM, Joplin GF, Bloom SR (1985) Chronic treatment of acromegaly with a long-acting somatostatin analogue. Br Med J 290: 284–285CrossRefGoogle Scholar
  2. 2.
    Lamberts SWJ, Oosterman R, Neufeld M, Del Pozo E (1985) The somatostatin analogue SMS 201-995 induced long-acting inhibition of growth hormone secretion without rebound hypersecretion in acromegalic patients. J Clin Endocrinol Metab 60: 1161–1165CrossRefPubMedGoogle Scholar
  3. 3.
    Richmond W, Seviour PW, Teal TK, Elkeles RS (1987) Analgesic effect of somatostatin analogue (octreotide) in headache associated with pituitary tumours. Br Med J 295: 247–248CrossRefGoogle Scholar
  4. 4.
    Sandler LM, Burrin JM, Williams G, Joplin GF, Can DH, Bloom SR (1987) Effective long-term treatment of acromegaly with a long-acting somatostatin analogue (SMS 201995). Clin Endocrinol 26: 85–95CrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1988

Authors and Affiliations

  • D. Killinger
    • 1
  • J. Gonzalez
    • 1
  1. 1.Department of MedicineUniversity of TorontoTorontoCanada

Personalised recommendations