Treatment of Acromegaly with the Somatostatin Analogue SMS 201–995 (Sandostatin®)
The long-acting somatostatin analogue SMS 201–995 (Sandostatin®) has recently been introduced for the treatment of acromegaly . We have evaluated its efficacy and long-term usefulness in 12 patients with therapy-resistant disease. All had been previously treated by transsphenoidal surgery, irradiation, bromocriptine or a combination of these but their GH concentrations had been insufficiently lowered. Duration of Sandostatin treatment was at least 12 months in all patients.
KeywordsProlactin Acromegaly Bromocriptine Sandostatin
- 1.Bauer W, Briner U, Doepfner W, Haller R, Huguenin R, Marbach P, Petcher TJ, Pless J (1982) SMS 201-995: A very potent and selective octapeptide analogue of somatostatin with prolonged action. Life Sci 31: 1133–1140Google Scholar