Cell Lineage and Segmentation in Development

  • G. S. Stent
Conference paper
Part of the Springer Series in Synergetics book series (SSSYN, volume 39)


Studies of developmental cell lineage — that is of the fate of individual cells, or blastomeres, that arise in the early embryo — were begun in the 1870’s, in the context of the controversy then raging about Ernst Haeckel’s “biogenetic” law. The biogenetic law seemed to imply that cells of the metazoan blastula recapitulate the non-differentiated tissues of a remote sponge-like ancestor. Only after gastrulation would the germ layers — ectoderm, mesoderm, endoderm - be destined to form the highly differentiated tissues characteristic of more recent metazoan ancestors. This implication was tested by the founder of American experimental embryology, Charles O. WHITMAN (1887) [1]. By observing the cleavage pattern of early leech embryos — which is also the main experimental material of this brief review article — Whitman traced the fate of individual cells from the uncleaved egg to the germ-layer stage and concluded that, contrary to the implication of the biogenetic law, a characteristic postembryonic fate can be assigned to each identified blastomere and to the clone of its descendant cells. These findings suggested, moreover, that the differentiated properties that characterize a given cell of the mature animal are somehow determined by its genealogical line of descent from the egg.


Blast Cell Ventral Nerve Cord Founder Cell Segmental Ganglion Segment Border 
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  1. 1.
    C.O. Whitman: J. Morphol. 1, 105 (1887)CrossRefGoogle Scholar
  2. 2.
    J.E. Sulston, E. Schierenberg, J.G. White, J.N. Thomson: Dev. Biol. 100, 64 (1983)CrossRefGoogle Scholar
  3. 3.
    G.S. Stent, D.A. Weisblat, S.S. Blair, S.L. Zackson: In Neuronal Development, ed. by N. Spitzer (Plenum, New York 1982) p.1Google Scholar
  4. 4.
    A. Garcia-Bellido, J.R. Merriam: J. exp. Zool. 170, 61 (1969)CrossRefGoogle Scholar
  5. 5.
    G.S. Stent: Phil. Trans. R. Soc. Lond. B312, 3 (1985)ADSGoogle Scholar
  6. 6.
    E.R. Lankester: In Encyclopaedia Britannica, 13th ed., Vol. 18 (Encyclopaedia Britannica Co., London, New York 1926) p. 215Google Scholar
  7. 7.
    W.J. Ouweneel: Adv. Genet. 18, 179 (1976)CrossRefGoogle Scholar
  8. 8.
    E.B. Lewis: Nature 276, 565 (1978)ADSCrossRefGoogle Scholar
  9. 9.
    S.A. Torrence, D.K. Stuart: J. Neurosci. 6, 2736 (1986)Google Scholar
  10. 10.
    D.A. Weisblat, R.T. Sawyer, G.S. Stent: Science 202, 1295 (1978)ADSCrossRefGoogle Scholar
  11. 11.
    D.A. Weisblat, S.Y. Kim, G.S. Stent: Dev. Biol. 104, 65 (1984)CrossRefGoogle Scholar
  12. 12.
    D.A. Weisblat, S.L. Zackson, S.S. Blair, J.D. Young: Science 209, 1538 (1980)ADSCrossRefGoogle Scholar
  13. 13.
    M. Shankland: Nature 307, 541 (1984)ADSCrossRefGoogle Scholar
  14. 14.
    D.A. Weisblat, M. Shankland: Phil. Trans. R. Soc. Lond. B312, 39 (1985)ADSGoogle Scholar
  15. 15.
    D.A. Weisblat, S.S. Blair: Dev. Biol. 101, 326 (1984)CrossRefGoogle Scholar
  16. 16.
    M. Shankland, D.A. Weisblat: Dev. Biol. 106, 326 (1984)CrossRefGoogle Scholar
  17. 17.
    A. Martinez-Arias, P.A. Lawrence: Nature 313, 639 (1985)ADSCrossRefGoogle Scholar
  18. 18.
    C. Nüsslein-Volhard, H. Kluding, G. Jürgens: Cold Spring Harbor Symp. quant. Biol. 50, 145 (1985)Google Scholar
  19. 19.
    C. Nüsslein-Volhard, E. Wieschaus, G. Jürgens: In Verhandlungen der Deutschen Zoologischen Gesellschaft (Gustav Fischer, Stuttgart 1982) p. 91Google Scholar
  20. 20.
    H. Meinhardt: J. Cell. Sci. Suppl. 4, 357 (1986)Google Scholar
  21. 21.
    D.F. Poulson: In The Biology of Drosophila, ed. by M. Demerec (Wiley, New York 1950) p. 168Google Scholar
  22. 22.
    V. Hartenstein, J.A. Campos-Ortega: Roux’s Arch. Devl. Biol. 193, 308 (1984)CrossRefGoogle Scholar
  23. 23.
    F.H.C. Crick, P.A. Lawrence: Science 189, 340 (1975)ADSCrossRefGoogle Scholar
  24. 24.
    A. Garcia-Bellido, P. Ripoll, G. Morata: Nature, new Biol. 245, 251 (1973)CrossRefGoogle Scholar
  25. 25.
    E.B. Wilson: In Biological Lectures (Woods Hole: Marine Biological Lab. 1898), p.21 [Reprinted in Foundations of Experimental Biology, 2nd ed., ed. by B.H. Willier and J.M. Oppenheimer (Hafner Press, New York) p. 52]Google Scholar
  26. 26.
    F. Jacob: The Possible and the Actual (University of Washington Press, Seattle, London 1982) p. 71Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • G. S. Stent
    • 1
  1. 1.Department of Molecular BiologyUniversity of CaliforniaBerkeleyUSA

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