Nonlinear Polymerization of Fibrinogen
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Conversion of fibrinogen into fibrin by a polymerization process is coupled to periodic conformational transitions which are induced by the catalytic cleavage of fibrinogen. During the polymerization a regular 3-dimensional network is formed. Its pore size, as well as the oscillatory transitions, depends on the activity of thrombin, which catalyses the cleavage of fibrinogen. The formation of the fibrin network appears as an ideal model system for studying the formation of ordered 3-dimensional biological structures from a random distribution of structural elements.
KeywordsEnzyme Concentration Fibrin Network Imidazole Buffer Ideal Model System Dynamic Laser Light Scattering
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