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Rökan pp 143-152 | Cite as

Effects of Ginkgo Biloba Extract on a Cerebral Ischemia Model in Gerbils

  • B. Spinnewyn
  • N. Blavet
  • F. Clostre
Conference paper

Summary

Certain anatomical characteristics peculiar to the gerbil make it the animal model best adapted to experimental pathology studies of acute ischaemia.

In this animal species, devoid of any substitute vertebro-basilar vascular tissue, unilateral ligature of the carotid artery produces a cerebral ischaemia with neurological signs (well quantifiable), metabolic perturbations (especially mitochondrial) and cerebral oedema development closely resembling the symptoms revealed by physiopathology in human clinical studies.

Using this model and under the experimental conditions described, clear-cut, highly significant results were obtained with Ginkgo biloba, whether by oral or intravenous administration.

These results were normalization of mitochondrial respiration, diminution of cerebral oedema, correction of the accompanying ionic pertubarations, and practically total functional restoration revealed by a normal neurological index in the gerbils treated with Ginkgo biloba extract.

Keywords

Cerebral Ischemia Cerebral Edema Mitochondrial Respiration Mongolian Gerbil Stroke Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg New York 1988

Authors and Affiliations

  • B. Spinnewyn
    • 1
  • N. Blavet
    • 1
  • F. Clostre
    • 1
  1. 1.Centre de recherche I.H.B.-I.P.S.E.N.Les UlisFrance

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