Summary
Certain anatomical characteristics peculiar to the gerbil make it the animal model best adapted to experimental pathology studies of acute ischaemia.
In this animal species, devoid of any substitute vertebro-basilar vascular tissue, unilateral ligature of the carotid artery produces a cerebral ischaemia with neurological signs (well quantifiable), metabolic perturbations (especially mitochondrial) and cerebral oedema development closely resembling the symptoms revealed by physiopathology in human clinical studies.
Using this model and under the experimental conditions described, clear-cut, highly significant results were obtained with Ginkgo biloba, whether by oral or intravenous administration.
These results were normalization of mitochondrial respiration, diminution of cerebral oedema, correction of the accompanying ionic pertubarations, and practically total functional restoration revealed by a normal neurological index in the gerbils treated with Ginkgo biloba extract.
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References
Chance B., Williams G.R.: The respiratory chain and oxydative phosphorylation. Nature, 1955, 175, 1120–1121.
Chatterjee S.S.: Effects of Ginkgo biloba Extract on cerebral metabolic processes. In: Effects of Ginkgo biloba on organic cerebral impairment, Agnoli A., Rapin J.R., Scapagnini V., Weitbrecht W.V. Eds., John Libbey, London, 1985, 5–15.
Delbarre B., Delbarre G.: La gerbille comme modèle d’ischémie cérébrale, J. Int. Médecine. 1984, 9, Suppl. n° 50, 11–14.
Fieschi C., Lenzi G.L.: Experimental models of focal cerebral ischemia. In: Cerebral Ischemia, Bes A., Braquet P., Paoletti R., Siesjö B.K. Eds., Excerpta Medica, 1984, 57–62.
Gotti B., Mackenzie E.T., Nowicki J.P., Young A.R.: Pharmacothérapie de l’ischémie cérébrale focale. Actua Clin. Ther. 1983, 10, 114–124.
Holtzman D., Lewinston N., Herman N.M., Desantel M., Brewer E., Robin E.: Effects of osmolar changes on isolated mitochondria of brain and liver. J. Neurochem., 1978, 30, 1409–1419.
Ito U.: Brain edema during ischemia and after restoration of blood flow. Measurement of water, sodium, potassium content and plasma protein permeability. Stroke, 1979, 10, 542–547.
Kahn K.: The natural course of experimental cerebral infarction in the Gerbil. Neurology, 1972, 22, 510–515.
Karcher L., Zagermann P., Krieglstein J.: Effect of an extract of Ginkgo biloba on rat brain energy metabolism in hypoxia. Naunyn—Schmiedeberg’s Arch. Pharamacol., 1984, 327, 31–35.
Larssen R.G., Dupeyron J.P., Boulu R.G.: Modèle d’ischémie cérébrale expérimentale par microsphères chez le rat. Etude de l’effet de deux extraits de Ginkgo biloba et du naftidrofuryl. Thérapie, 1978, 33, 651–660.
Le Poncin Lafitte M., Martin P., Lespinasse P., Rapin J.R.: Ischémie cérébrale après ligature non simultanée des artères carotides chez le rat: effet de l’extrait de Ginkgo biloba. Sem. Hôp. Paris, 1982, 58, 403–406.
Levines S., Payan H.: Effects of ischemia and other procedures on the brain and retina of the gerbil (Meriones unguiculatus). Exp. Neurol., 1966, 16, 255–262.
MacGraw C.P.: Experimental cerebral infarction. Effects of pentobarbital in mongolian gerbils. Arch. Neurol., 1977, 34, 334–336.
Nowicki J.P., MacKenzie E.T., Spinnewyn B.: Effects of agents used in the pharmacotherapy of cerebrocvascular disease on the oxygen consumption of isolated cerebral mitochondria. J. Cerebral Blood Flow Metabolism, 1982, 2, 33–40.
Petter F.: La diversité des Gerbillidés. ln: Rodents in desert environment, Junk W. Ed., The Hague, 1975, 47–52.
Petter F.: Les principales particularités du comportement des rongeurs de la famille des gerbillidés. Sci. Tech. Anim. Lab., 1984, 9, 229–231.
Tanimoto K.: Ecological studies on plague-carrying in Manchuria Dobutsugaku Zasski. Zool. Mag. Tokyo, 1943, 55, 111–127.
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© 1988 Springer-Verlag Berlin Heidelberg New York
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Spinnewyn, B., Blavet, N., Clostre, F. (1988). Effects of Ginkgo Biloba Extract on a Cerebral Ischemia Model in Gerbils. In: Fünfgeld, E.W. (eds) Rökan. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73686-5_16
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DOI: https://doi.org/10.1007/978-3-642-73686-5_16
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