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Interaction of Class I Drugs with the Cardiac Sodium Channel

  • Chapter
Antiarrhythmic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 89))

Abstract

In the preceding chapters it was shown that, based upon electrophysiological principles, arrhythmias can be classified according to mechanisms, and antiarrhythmic agents also can be grouped into several classes and subclasses (see Chaps. 4, 2). In the present chapter, I will describe the electrophysiological basis for subclassification of sodium channel blocking (class I) antiarrhythmic agents and review current models for their mechanism of action. Interactions of multiple agents with a common receptor and clinical implications will be emphasized. Although the chapter will be limited to the sodium channel receptor, it should be noted that these principles can be applied equally well to other classes of antiarrhythmic agents (Hondeghem and Katzung 1984; Roden et al. 1986).

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Authors
  1. L. M. Hondeghem
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Editors and Affiliations

  1. Hertford College, Oxford University, 153 Woodstock Road, Oxford, OX2 7NA, Great Britain

    E. M. Vaughan Williams Professor Dr.

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© 1989 Springer-Verlag Berlin Heidelberg

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Hondeghem, L.M. (1989). Interaction of Class I Drugs with the Cardiac Sodium Channel. In: Vaughan Williams, E.M. (eds) Antiarrhythmic Drugs. Handbook of Experimental Pharmacology, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73666-7_8

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  • DOI: https://doi.org/10.1007/978-3-642-73666-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73668-1

  • Online ISBN: 978-3-642-73666-7

  • eBook Packages: Springer Book Archive

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