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Subclassification of Class I Antiarrhythmic Drugs

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Book cover Antiarrhythmic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 89))

Abstract

Class I comprises a very large number of compounds with widely disparate chemical structures and clinical electrophysiological properties (see Chaps. 2, 9–11). They are grouped together because they share the ability to block the fast inward sodium current in cardiac muscle. It is not surprising, therefore, that there have been a number of attempts to subclassify these agents into smaller, more homogeneous groups. Indeed, as was discussed in Chap. 2, there was at one time considerable disagreement regarding the inclusion of lidocaine and diphenylhydantoin as class I drugs at all.

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  1. T. J. Campbell
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  1. Hertford College, Oxford University, 153 Woodstock Road, Oxford, OX2 7NA, Great Britain

    E. M. Vaughan Williams Professor Dr.

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Campbell, T.J. (1989). Subclassification of Class I Antiarrhythmic Drugs. In: Vaughan Williams, E.M. (eds) Antiarrhythmic Drugs. Handbook of Experimental Pharmacology, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73666-7_7

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