Subclassification of Class I Antiarrhythmic Drugs

  • T. J. Campbell
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 89)


Class I comprises a very large number of compounds with widely disparate chemical structures and clinical electrophysiological properties (see Chaps. 2, 9–11). They are grouped together because they share the ability to block the fast inward sodium current in cardiac muscle. It is not surprising, therefore, that there have been a number of attempts to subclassify these agents into smaller, more homogeneous groups. Indeed, as was discussed in Chap. 2, there was at one time considerable disagreement regarding the inclusion of lidocaine and diphenylhydantoin as class I drugs at all.


Sodium Channel Antiarrhythmic Drug Action Potential Duration Sodium Current Effective Refractory Period 
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  • T. J. Campbell

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