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Antiarrhythmic Drugs pp 601–620Cite as

Clinical and Pharmacologic Characterization and Treatment of Potentially Malignant Arrythmias of Chronic Chagasic Cardiomyopathy

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 89))

Abstract

Chagas’ disease is a widespread parasitosis affecting most Latin American countries (Carcavallo 1975; Coura 1966; Marinkelle 1975; Osimani 1972; Ponce and Zeledon 1973). The etiologic agent is a protozoan, Trypanosoma cruzi 1. This parasite is commonly transmitted to humans by hematophagous insects generically known as “triatomes,” although transmission by blood transfusion is not infrequent, and congenital infection can also occur.

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References

  • Bigger JT Jr (1983) Definition of benign versus malignant ventricular arrhythmias: targets for treatment. Am J Cardiol 52: 47C–54C

    Article  PubMed  Google Scholar 

  • Brener Z (1982) Recent developments in the field of Chagas’ disease. Bull WHO 60: 463–473

    PubMed  CAS  Google Scholar 

  • Carcavallo RV (1975) Aspects of the epidemiology of Chagas’ disease in Venezuela and Argentina. In: Pan American Health Organization (ed) American trypanosomiasis research. Pan American Health Organization, Washington DC, pp 374–383

    Google Scholar 

  • Chiale PA, Halpern MS, Nau GJ, Przybylski J, Tambussi AM, Lázzari JO, Elizari MV, Rosenbaum MB (1982) Malignant ventricular arrhythmias in chronic chagasic myocarditis. PACE 5: 162–172

    PubMed  CAS  Google Scholar 

  • Chiale PA, Halpern MS, Nau GJ, Tambussi AM, Przybylski J, Lázzari JO, Elizari MV, Rosenbaum MB (1984) Efficacy of amiodarone during long-term treatment of malignant ventricular arrhythmias in patients with chronic chagasic myocarditis. Am Heart H 107: 656–665

    Article  CAS  Google Scholar 

  • Coura JR (1966) Contribuçao ao estudo da doença de Chagas no estado de Guanabara. Rev Bras Malariol Doen9as Trop 18: 9–15

    CAS  Google Scholar 

  • Duff HJ, Roden D, Primum K, Oates JA, Woosley RL (1983) Mexiletine in the treatment of resistant ventricular arrhythmias: enhancement of efficacy and reduction of dose related side effects by combination with quinidine. Circulation 67: 1124–1128

    Article  PubMed  CAS  Google Scholar 

  • Elizari MV, Levi RJ, Novakoski A, Làzzari JO, Vetulli HM (1980) Cellular effects of antiarrhythmic drugs. Remarks on methodology. VIII European Congress of Cardiology, Paris, p 11

    Google Scholar 

  • Faria CAF, Veloso C, Carvallo CA (1983) Parassístole ventricular dupla espontánea em paciente portador de cardiopatia chagasica. Relato de um caso. Arq Bras Cardiol 41: 385–388

    PubMed  CAS  Google Scholar 

  • Haedo AH, Chiale PA, Bandieri JD, Làzzari JO, Elizari MV, Rosenbaum MB (1986) Comparative antiarrhythmic efficacy of verapamil, 17-monochloracetilajmaline, mexiletine and amiodarone in patients with severe chagasic myocarditis: relation with the underlying arrhythmogenic mechanisms. J Am Coll Cardiol. 7: 1114–1120

    Article  PubMed  CAS  Google Scholar 

  • Heger JJ, Prystowsky EN, Jackman WM, Naccarelli GV, Warfel KA, Rinkenberger RL, Zipes DP (1981) Amiodarone. Clinical efficacy and electrophysiology during long- term therapy for recurrent ventricular tachycardia or ventricular fibrillation. N Engl J Med 305: 539–547

    Article  PubMed  CAS  Google Scholar 

  • Holt DW, Tucker GT, Jackson PR, Storey GCA (1983) Amiodarone pharmacokinetics. Am Heart J 106: 788–797

    Article  Google Scholar 

  • Jorge PAR, Nogueira EA, Bittencourt LAK, Fortuna ABP, Terzi RGG, Vieira RW (1978) Arritmia cardiaca a lesao apical na cardiopatia chagasica cronica. Considerares a respeito de un caso. Arq Bras Cardiol 31: 135–137

    PubMed  CAS  Google Scholar 

  • Kaski JC, Girotti LA, Messuti H, Rutitzky B, Rosenbaum MB (1981) Long-term management of sustained, recurrent, symptomatic ventricular tachycardia with amiodarone. Circulation 64: 273–279

    Article  PubMed  CAS  Google Scholar 

  • Kirchhoff LV, Neva FA (1985) Chagas’ disease in Latin American immigrants. JAMA 254: 3058–3060

    Article  PubMed  CAS  Google Scholar 

  • Lamourier EN, Herrmann JLV, Martinez Filho EE, Buffolo E, De Andrade JCS, Korkes H, Schubsky V, Ferreira C, Barcellini A, Portugal OP (1975) Aneurismectomia como tratamento de taquiarritmias refratarias en pacientes portadores de aneurisma ventricular de etiologia chagasica. Arq Bras Cardiol 28: 549–555

    PubMed  CAS  Google Scholar 

  • Leahey EB Jr, Heissenbuttel RH, Giardina EGV, Bigger JT Jr (1980) Combined mexiletine and propranolol treatment of refractory ventricular tachycardia. Br Med J [Clin Res] 281: 357–358

    Article  CAS  Google Scholar 

  • Marinkelle CJ (1975) Epidemiology of Chagas’ disease in Colombia. In: Pan American Health Organization (ed) American trypanosomiasis research. Pan American Health Organization, Washington DC, pp 340–345

    Google Scholar 

  • Nademanee K, Hendrickson BS, Cannon DS, Goldreyer BN, Singh BN (1981) Control of refractory life-threatening ventricular arrhythmias by amiodarone. Am Heart J 101: 759–768

    Article  PubMed  CAS  Google Scholar 

  • Nademanee K, Singh BN, Cannon DS, Weiss S, Feld G, Stevenson WG (1983) Control of sudden recurrent arrhythmic deaths: role of amiodarone. Am Heart J 106: 895–901

    Article  PubMed  CAS  Google Scholar 

  • Nau GJ, Acunzo RS, Sáleme JP, Aldariz A, Elizari MV, Rosenbaum MB (1985) Características clínicas, evaluación y pronóstico de las parasistolias ventriculares. Rev Arg Cardiol 53: 553 (Abstract)

    Google Scholar 

  • Osmani JJ (1972) Epidemiología de la enfermedad de Chagas en Uruguay. In: Secretaría de Salud Pública de la República Argentina (ed) Simposio Internacional sobre Enfermedad de Chagas. Buenos Aires, pp 209–214

    Google Scholar 

  • Pearlman JD (1983) Chagas’ disease in Northern California. No longer an endemic diagnosis. Am J Cardiol 75: 1057–1060

    CAS  Google Scholar 

  • Peralta JM (1981) Auto-antibodies and chronic Chagas’ heart disease. Trans R Soc Trop Med Hyg 75: 568–569

    Article  PubMed  CAS  Google Scholar 

  • Ponce C, Zeledon R (1973) La enfermedad de Chagas en Honduras. Bol Of Sanit Panam 75: 239–247

    CAS  Google Scholar 

  • Prata A (1975) Natural history of chagasic cardiomyopathy. In: Pan American Health Organization (ed) American trypanosomiasis research. Washington DC, p 191

    Google Scholar 

  • Reis Lopes E, Chapadeiro E, Almeida HC, Rocha A, Prata A (1974) Doença de Chagas e morte subita. X Congreso Brasileiro de patología e i encontro Luso-Brasileiro de anatomía patológica. Curitiba, Paraná, Brazil (Abstract)

    Google Scholar 

  • Reis Lopes E, Chapadeiro E, Almeida HC, Rocha A (1976) Contribusao ao estudo de anatomía patológica dos cora5oes de chagasicos falecidos súbitamente. Rev Soc Bras Med Trop 9: 269–279

    Google Scholar 

  • Ribeiro dos Santos R, Hudson L (1980) Trypanosoma cruzi: immunological consequences of parasite modification of host cells. Clin Exp Immunol 40: 36–41

    PubMed  CAS  Google Scholar 

  • Rosenbaum MB (1964) Chagasic myocardiopathy. Prog Cardiovasc Dis 7: 199–225

    Article  PubMed  CAS  Google Scholar 

  • Rosenbaum MB, Chiale PA, Haedo AH, Elizari MV (1983) Ten years of experience with amiodarone. Am Heart J 101: 957–964

    Article  Google Scholar 

  • Sachs RN, Lanfranchi J (1978) Cardiomyopathies primitives et anomalies immunitaires. Coeur Med Int 17: 193–198

    CAS  Google Scholar 

  • Schmidberg JM, Acunzo RS, Nau GJ, Elizari MV, Rosenbaum MB (1985) Eficacia del nadolol en el tratamiento de las arritmias ventriculares inducidas o agravadas por la ergometría. Rev Arg Cardiol 53: S130 (Abstract)

    Google Scholar 

  • Sobol SM, Rakita L (1982) Pneumonitis and pulmonary fibrosis associated with amiodarone treatment: a possible complication of a new antiarrhythmic drug. Circulation 65: 819–822

    Article  PubMed  CAS  Google Scholar 

  • Waleffe A, Mary-Rabine L, Legrand V, Demoulin JCL, Kulbertus HE (1980) Combined mexiletine and amiodarone treatment of refractory recurrent ventricular tachycardia. Am Heart J 100: 788–793

    Article  PubMed  CAS  Google Scholar 

  • Winkle RA (1978) Antiarrhythmic drug effect mimicked by spontaneous variability of ventricular ectopy. Circulation 57: 1116–1120

    PubMed  CAS  Google Scholar 

  • Winkle RA, Meffin PJ, Harrison DC (1978 a) Long-term tocainide therapy for ventricular arrhythmias. Circulation 57: 1008–1011

    PubMed  CAS  Google Scholar 

  • Winkle RA, Gradman AH, Fitzgerald JW (1978 b) Antiarrhythmic drug effect assessed from ventricular arrhythmias reduction in the ambulatory electrocardiogram and treadmill test: comparison of propranolol, procainamide, and quinidine. Am J Cardiol 42: 473–484

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. P. A. Chiale
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  2. M. B. Rosenbaum
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Editor information

Editors and Affiliations

  1. Hertford College, Oxford University, 153 Woodstock Road, Oxford, OX2 7NA, Great Britain

    E. M. Vaughan Williams Professor Dr.

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© 1989 Springer-Verlag Berlin Heidelberg

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Chiale, P.A., Rosenbaum, M.B. (1989). Clinical and Pharmacologic Characterization and Treatment of Potentially Malignant Arrythmias of Chronic Chagasic Cardiomyopathy. In: Vaughan Williams, E.M. (eds) Antiarrhythmic Drugs. Handbook of Experimental Pharmacology, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73666-7_29

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  • DOI: https://doi.org/10.1007/978-3-642-73666-7_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73668-1

  • Online ISBN: 978-3-642-73666-7

  • eBook Packages: Springer Book Archive

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