Eicosanoids and Arrhythmogenesis

  • J. R. Parratt
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 89)


Most standard approaches to antiarrhythmic therapy, for example in myocardial ischaemia, involve the administration of synthetic drugs that directly modify ionic exchange across myocardial cell membranes. However, there may be less direct ways of reducing the severity of such arrhythmias. These depend on modulating the release, or cellular effects, of biochemical and metabolic factors that themselves influence sarcolemmal ionic flux. Thus, such ischaemia-induced arrhythmias may result in part from the release of endogenous arrhythmogenic substances. A good example of an approach which attempts to modulate the effects of such an arrhythmogenic biochemical factor is the use of beta-adrenoceptor-blocking drugs to antagonize the effects of noradrenaline and adrenaline released during myocardial ischaemia. There are other less well appreciated possibilities. Examples include the ability of certain antagonists of both 5-HT and opioid peptides to reduce the severity of ischaemic arrhythmias in experimental animals (Coker et al. 1986; Fagbemi et al. 1982; Parratt and Sitsapesan 1986).


Prostaglandin Ibuprofen Nifedipine Captopril Salicylate 


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© Springer-Verlag Berlin Heidelberg 1989

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  • J. R. Parratt

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