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Alpha-Adrenoceptors in Arrhythmogenesis

  • Chapter
Antiarrhythmic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 89))

  • 178 Accesses

Abstract

Since alpha-adrenoceptors perform many physiological roles in the nervous and cardiovascular systems it is inevitable that, theoretically, their activation or blockade will impinge on any dysrhythmogenic process. Empirical observation also clearly shows that activation of the sympathetic nervous system can be dysrhythmogenic (Chap. 12), either when it is excessive or when some defect of cardiac function already exists, and that drugs which are known to be alpha-adrenoceptor antagonists can alleviate this. At present the fundamental basis of this phenomenon is not entirely clear. Consequently an opportunity may exist, by clarifying this, to increase the rational basis of antiarrhythmic therapy. To this end, this chapter reviews the roles of alpha-adrenoceptors in the heart or with a bearing on cardiac function, with particular emphasis on possible influences on normal or abnormal cardiac rhythm.

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  1. J. C. McGrath
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  1. Hertford College, Oxford University, 153 Woodstock Road, Oxford, OX2 7NA, Great Britain

    E. M. Vaughan Williams Professor Dr.

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McGrath, J.C. (1989). Alpha-Adrenoceptors in Arrhythmogenesis. In: Vaughan Williams, E.M. (eds) Antiarrhythmic Drugs. Handbook of Experimental Pharmacology, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73666-7_23

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  • DOI: https://doi.org/10.1007/978-3-642-73666-7_23

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