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Amiodarone: Electropharmacologic Properties

  • Chapter
Antiarrhythmic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 89))

Abstract

Developed specifically as a coronary vasodilator and an antianginal compound in 1962, in the past 10 years or so amiodarone hydrochloride (Fig. 1) has recently attracted much experimental and clinical interest as an antiarrhythmic agent. Few, if any, other antidysrhythmic compounds have stimulated as much interest as has amiodarone in relation to the control of refractory arhythmias. Its extreme potency in the prophylactic control of most supraventricular and ventricular arrhythmias is now well established (Rosen- Baum et al. 1976, 1983; Heger et al. 1981, 1984; Nademanee et al. 1981, 1982a, 1983; Graboys et al. 1983; Zipes et al. 1984; Singh et al. 1980). However, the fundamenal mechanism whereby it induces its salutary effects is far from being certain. For this reason, the effects of the compound on cardiac electrophysiology relative to its associated pharmacologic properties are of much theoretical as well as practical importance.

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  1. B. N. Singh
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  1. Hertford College, Oxford University, 153 Woodstock Road, Oxford, OX2 7NA, Great Britain

    E. M. Vaughan Williams Professor Dr.

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Singh, B.N. (1989). Amiodarone: Electropharmacologic Properties. In: Vaughan Williams, E.M. (eds) Antiarrhythmic Drugs. Handbook of Experimental Pharmacology, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73666-7_16

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  • DOI: https://doi.org/10.1007/978-3-642-73666-7_16

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