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Class III Antiarrhythmic Action

  • Chapter
Antiarrhythmic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 89))

Abstract

Class III antiarrhythmic action, e.g. the principle of delayed myocardial repolarization as an antiarrhythmic action, was described in 1970. This mode of action has become increasingly interesting with the increasing knowledge about mechanisms involved in initiation and perpetuation of cardiac arrhythmias and with the increasing number of antiarrhythmic drugs belonging to this class. Consequently, the possible class III mode of action of different antiarrhythmic drugs has been analyzed also in the intact human heart. For this purpose, several different methods have been applied. The present paper aims to describe some basic facts of importance for the demonstration and interpretation of delayed repolarization as an antiarrhythmic action in the clinical setting and to give some examples of this mechanism.

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Authors
  1. S. B. Olsson
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Editors and Affiliations

  1. Hertford College, Oxford University, 153 Woodstock Road, Oxford, OX2 7NA, Great Britain

    E. M. Vaughan Williams Professor Dr.

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© 1989 Springer-Verlag Berlin Heidelberg

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Olsson, S.B. (1989). Class III Antiarrhythmic Action. In: Vaughan Williams, E.M. (eds) Antiarrhythmic Drugs. Handbook of Experimental Pharmacology, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73666-7_15

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  • DOI: https://doi.org/10.1007/978-3-642-73666-7_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73668-1

  • Online ISBN: 978-3-642-73666-7

  • eBook Packages: Springer Book Archive

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