Tumor Imaging: Role of the Target Antigen

  • S. Matzku
  • W. Tilgen
  • H. Bihl
  • K. Schwechheimer
  • H. Kalthoff
  • W. Schmiegel
Conference paper


Tumor localization with monoclonal antibodies (MAbs) is fairly successful when MAbs are recognizing glycoconjugates, epitopes being variably associated with different types of surface molecules and with high molecular weight secretory products, especially mucins. It appears that extracellular pools of antigen in tumor tissue with remnants of epithelial organization offer particularly favourable conditions for MAb access. The problem of access has been adressed by using a new monoclonal anti-mucin antibody (RA-96), which shows excellent targeting properties to tissular deposits, although the target epitope is not detectable at the surface of tumor cells.


Antigen Distribution Extracellular Pool Mucin Antigen Mucin Molecule Human Mammary Tumor Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • S. Matzku
    • 1
  • W. Tilgen
    • 2
  • H. Bihl
    • 2
  • K. Schwechheimer
    • 2
  • H. Kalthoff
    • 3
  • W. Schmiegel
    • 3
  1. 1.Institut für NuklearmedizinDeutsches KrebsforschungszentrumHeidelbergGermany
  2. 2.University of HeidelbergGermany
  3. 3.University of HamburgGermany

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