Soluble Lectins and Endothelial Cell Growth Factors

  • M. Caron
  • R. Joubert
  • D. Bladier
Conference paper


We have seen during this symposium how an aberrant expression of endogenous lectins or their receptors may be associated with different types of human or animal malignant transformation. The alteration of glycoproteins or other glycoconjugates on the cell surface or in the extracellular matrix may influence cell proliferation, thus modulating the development of tumors and modifying the social behaviour of the cells. To form metastasis, in addition to the enzymatic destruction of tissue barriers, malignant cells must recognize vascular endothelial cells or subendothelial matrix components as an attachment substratum and adhere to them. Several studies suggest that lectins and glycoconjugates may contribute to these processes (Nicolson, 1984; Gabius, 1987 a).


Hemagglutination Activity Heparin Binding Subunit Molecular Weight Acidic Fibroblast Growth Factor Influence Cell Proliferation 
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  1. Barondes SH (1984) Soluble lectins: a new class of extracellular proteins. Science 233: 1259–1264CrossRefGoogle Scholar
  2. Barritault D, Plouet J, Courty J, Courtois Y (1982) Purification, characterization and biological properties of the eye-derived growth factor from. retina: analogies with brain-derived growth factor. Neurosci Res 8: 477–490CrossRefGoogle Scholar
  3. Bohlen P, Baird A, Esch F, Ling N, Gospodarowicz D (1984) Isolation and partial molecular characterization of pituitary fibroblast growth factor. Proc Natl Acad Sci USA 81: 5364–5368PubMedCrossRefGoogle Scholar
  4. Caron M, Joubert R, Bladier D (1986) Cell growth factors and soluble lectins. Trends Biochem Sci 11: 319CrossRefGoogle Scholar
  5. Ceri H., Kobiler D, Barondes SH (1981) Heparin-inhibitable lectin. Purification from chicken liver and embryonic chicken muscle. J Biol Chem 256: 390–394PubMedGoogle Scholar
  6. Courty J, Loret C, Moenner M, Chevalier B, Lagente O, Courtois Y, Barritault D (1986) Bovine retina contains three growth factor activities with different affinity for heparin: eye-derived growth factor I, Il and Ill. Biochimie 67: 265–269Google Scholar
  7. Courty J, Loret C, Chevallier B, Moenner M, Barritault D (1987) Biochemical comparative studies between eye-and brain-derived growth factors. Biochimie 69: 511–516PubMedCrossRefGoogle Scholar
  8. Gabius HJ (1987) Endogenous lectins in tumors and the immune system. Cancer Invest 5: 39–46PubMedCrossRefGoogle Scholar
  9. Gabius H (1987) Vertebrate lectins and their possible role in fertilization, development and tumor biology. In vivo 1: 75–84Google Scholar
  10. Gospodarowicz D, Lui FM, Cheng J (1982) Purification in high yield of brain fibroblast growth factor by preparative isoelectric focusing at pH 9.6. J Biol Chem 257: 12266–12276PubMedGoogle Scholar
  11. Joubert R, Caron M, Bladier D (1986) Investigation on the occurence of soluble lectins in mammalian nervous tissue extracts. Comp Biochem Physiol 853: 859–863Google Scholar
  12. Kamo I, Furukawa S, Akazawa S, Fujisawa K, Tada-Kikuchi A, Nonaka I, Satoyoshi E (1986) Mitogenic heparin-binding lectin-like protein from cloned thymic myoid cells. Cell Immunol 103: 183–190PubMedCrossRefGoogle Scholar
  13. Klagsbrun M (1987) Regulation of basic fibroblast growth factor activity. Meeting Les Facteurs de Croissance en Cancérologie. Société Français du Cancer. Club des Facteurs de CroissanceGoogle Scholar
  14. Klagsbrun M, Shing Y (1985) Heparin affinity of anionic and cationic capillary endothelial cell growth factors. Analysis of hypothalamus-derived growth factors and fibroblast growth factors.Google Scholar
  15. Klagsbrun M, Sasse J, Sullivan R, Smith JA (1986) Human tumor cells synthetize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor. Proc Natl Acad Sci USA 83: 2448–2452PubMedCrossRefGoogle Scholar
  16. Lipsick JS, Beyer EC, Barondes SH, Kaplan NO (1986) Lectins from chicken tissues are mitogenic for thy-1 negative murine spleen cells. Biochem Biophys Res Comm 97: 56–61CrossRefGoogle Scholar
  17. Maciag T, Cerundolo J, Ilsley S, Kelley PR, Forand R (1979) An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization. Proc Natl Acad Sci USA 76: 5674–5678PubMedCrossRefGoogle Scholar
  18. Maciag T, Hoover GA, Weinstein R (1982) High and low molecular weight forms of endothelial cell growth factor. J Biol Chem 257: 5333–5336PubMedGoogle Scholar
  19. Nicolson GL (1984) Cell surface molecules and tumors metastasis. Exp Cell Res 150: 3–22PubMedCrossRefGoogle Scholar
  20. Pettmann B, Weibel M, Sensenbrenner M, Labourdette G (1985) Purification of two astroglial growth factors from bovine brain. FEBS Lett 189: 102–108PubMedCrossRefGoogle Scholar
  21. Pitts MJ, Yang DCH (1981) Mitogenicity and binding properties of ß-galactoside-binding lectin from chick-embryo kidney. Biochem J 195: 435–439PubMedGoogle Scholar
  22. Sirbasku DA, Riss, TL, Danielpour D, Ogasawa M, Karey KP (1987) Molecular properties of autocrine and endocrine growth factors for human, mouse and rat mammary tumor cells. In: Molecular Mechanisms in the Regulation of Cell Behaviour. Alan R Liss, Inc. pp 73–78Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. Caron
    • 1
  • R. Joubert
    • 1
  • D. Bladier
    • 1
  1. 1.Laboratoire de BiochimieUFR Santé, Médecine, Biologie HumaineBobigny cedexFrance

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