Soluble Lectins and Endothelial Cell Growth Factors
We have seen during this symposium how an aberrant expression of endogenous lectins or their receptors may be associated with different types of human or animal malignant transformation. The alteration of glycoproteins or other glycoconjugates on the cell surface or in the extracellular matrix may influence cell proliferation, thus modulating the development of tumors and modifying the social behaviour of the cells. To form metastasis, in addition to the enzymatic destruction of tissue barriers, malignant cells must recognize vascular endothelial cells or subendothelial matrix components as an attachment substratum and adhere to them. Several studies suggest that lectins and glycoconjugates may contribute to these processes (Nicolson, 1984; Gabius, 1987 a).
KeywordsHemagglutination Activity Heparin Binding Subunit Molecular Weight Acidic Fibroblast Growth Factor Influence Cell Proliferation
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