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Growth Rate, Iron Depletion, and a Sub-Minimal Inhibitory Concentration of Penicillin G Affect the Surface Hydrophobicity of Staphylococcus aureus

  • P. A. G. Domingue
  • E. Schwarzinger
  • M. R. W. Brown

Abstract

The surface composition of bacteria is important in interactions with the host [6, 11, 50] and with antibiotics [7, 8]. The surface is altered by the growth environment [6, 16, 50] so that bacteria become typical of it. Thus bacteria grown in vitro and in vivo reflect both genotypic and phenotypic changes [6, 14, 20, 51]. More attention to in vivo characteristics would enhance understanding of infectious processes, and in vitro design should account for this. We report on batch-culture conditions that approximate to in vivo conditions and that alter surface hydrophobicity (SH).

Keywords

Minimal Inhibitory Concentration Normal Human Serum Iron Depletion Iron Deprivation High Surface Hydrophobicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • P. A. G. Domingue
    • 1
  • E. Schwarzinger
    • 2
  • M. R. W. Brown
    • 1
  1. 1.Microbiology Research Group, Pharmaceutical Sciences Institute, Department of Pharmaceutical SciencesAston UniversityBirminghamUK
  2. 2.Sandoz Research InstituteViennaAustria

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