Growth Rate, Iron Depletion, and a Sub-Minimal Inhibitory Concentration of Penicillin G Affect the Surface Hydrophobicity of Staphylococcus aureus

  • P. A. G. Domingue
  • E. Schwarzinger
  • M. R. W. Brown


The surface composition of bacteria is important in interactions with the host [6, 11, 50] and with antibiotics [7, 8]. The surface is altered by the growth environment [6, 16, 50] so that bacteria become typical of it. Thus bacteria grown in vitro and in vivo reflect both genotypic and phenotypic changes [6, 14, 20, 51]. More attention to in vivo characteristics would enhance understanding of infectious processes, and in vitro design should account for this. We report on batch-culture conditions that approximate to in vivo conditions and that alter surface hydrophobicity (SH).


Minimal Inhibitory Concentration Normal Human Serum Iron Depletion Iron Deprivation High Surface Hydrophobicity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • P. A. G. Domingue
    • 1
  • E. Schwarzinger
    • 2
  • M. R. W. Brown
    • 1
  1. 1.Microbiology Research Group, Pharmaceutical Sciences Institute, Department of Pharmaceutical SciencesAston UniversityBirminghamUK
  2. 2.Sandoz Research InstituteViennaAustria

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