Pseudomonas aeruginosa: Alterations Induced by Low Concentrations of 4-Quinolones
Since the introduction of nalidixic acid in 1962, several compounds of this class (4-quinolones and in particular the fluoroquinolones), have been synthesized. These molecules have been shown to display an increased antibacterial potency and a broader spectrum. However, concerning potential direct interaction with the host defense system — in particular polymorphonuclear neutrophils (PMNs) — few data have been reported [3, 4, 8] and they do not indicate a significant increase in PMN function. On the contrary, several authors have shown that low concentrations of quinolones may alter bacteria in such a manner that these altered pathogens are significantly more sensitive than control ones to PMN killing [8, 9, 13]. The aim of our work was to analyze the effects of a low concentration of 4-quinolones on Pseudomonas aeruginosa, a strain which has lately emerged as an important pathogen with increasing resistance to antimicrobial agents.
KeywordsPseudomonas Aeruginosa Nalidixic Acid Subinhibitory Concentration Oxolinic Acid Killing Mechanism
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