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Pseudomonas aeruginosa: Alterations Induced by Low Concentrations of 4-Quinolones

  • M. T. Labro
  • A. Bryskier
  • C. Babin-Chevaye
  • J. Hakim

Abstract

Since the introduction of nalidixic acid in 1962, several compounds of this class (4-quinolones and in particular the fluoroquinolones), have been synthesized. These molecules have been shown to display an increased antibacterial potency and a broader spectrum. However, concerning potential direct interaction with the host defense system — in particular polymorphonuclear neutrophils (PMNs) — few data have been reported [3, 4, 8] and they do not indicate a significant increase in PMN function. On the contrary, several authors have shown that low concentrations of quinolones may alter bacteria in such a manner that these altered pathogens are significantly more sensitive than control ones to PMN killing [8, 9, 13]. The aim of our work was to analyze the effects of a low concentration of 4-quinolones on Pseudomonas aeruginosa, a strain which has lately emerged as an important pathogen with increasing resistance to antimicrobial agents.

Keywords

Pseudomonas Aeruginosa Nalidixic Acid Subinhibitory Concentration Oxolinic Acid Killing Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • M. T. Labro
    • 1
  • A. Bryskier
    • 2
  • C. Babin-Chevaye
    • 1
  • J. Hakim
    • 1
  1. 1.INSERM U. 294 et Laboratoire d’Hématologie et d’Immunologie CHU Xavier BichatParisFrance
  2. 2.Laboratoire de MicrobiologieCHG d’ArgenteuilFrance

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