Abstract
The new 4-quinolones such as ciprofloxacin, norfloxacin, and ofloxacin are strongly bactericidal, with activities approaching 1000 times that of nalidixic acid [12]. They are effective against a wider range of bacteria, including Pseudomonas aeruginosa and gram-positive cocci, which are considered resistant to nalidixic acid [6]. The activity of this family of drugs may be due to inhibition of bacterial DNA synthesis [5, 12]. Due to the great potential for the clinical use of these drugs it is important to investigate any possible positive or negative side effects on the host defense system.
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© 1989 Springer-Verlag Berlin Heidelberg
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Forsgren, A. (1989). Effect of 4-Quinolone Antibiotics on Cell Function, Cell Growth, and Pyrimidine Nucleotide Biosynthesis in Human Lymphocytes In Vitro. In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_35
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DOI: https://doi.org/10.1007/978-3-642-73653-7_35
Publisher Name: Springer, Berlin, Heidelberg
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