Effect of 4-Quinolone Antibiotics on Cell Function, Cell Growth, and Pyrimidine Nucleotide Biosynthesis in Human Lymphocytes In Vitro
The new 4-quinolones such as ciprofloxacin, norfloxacin, and ofloxacin are strongly bactericidal, with activities approaching 1000 times that of nalidixic acid . They are effective against a wider range of bacteria, including Pseudomonas aeruginosa and gram-positive cocci, which are considered resistant to nalidixic acid . The activity of this family of drugs may be due to inhibition of bacterial DNA synthesis [5, 12]. Due to the great potential for the clinical use of these drugs it is important to investigate any possible positive or negative side effects on the host defense system.
KeywordsHuman Lymphocyte Nalidixic Acid Antimicrob Agent Thymidine Incorporation Salvage Pathway
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