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Changes in the Immune Parameters of Antibiotic-Bacterial Interactions Induced by Hypothalamic and Other Electrolytic Brain Lesions Produced Through Stereotaxically Implanted Depth Electrodes

  • Conference paper
Book cover The Influence of Antibiotics on the Host-Parasite Relationship III

Abstract

In the years of 1952 through 1958, in a series of papers, Szentivanyi et al. [12, 11, 27, 31, 10, 32, 33, 26, 9, 30, 20] first described the critical role played by hypothalamic structures in the regulation and expression of immunologic inflammation, immunity, and hypersensitivity reactions. More recently rapidly growing extensive evidence demonstrated that neural and hormonal signals generated outside the immune system do indeed significantly contribute to immune homeostasis. These findings led to the identification of immune neuroendocrine circuits that are based on a bidirectional flow of information between the immune, endocrine, and nervous systems [13, 3, 19, 16]. These data also confirmed the conclusions reached in the earlier-mentioned works of Szentivanyi et al. that a critical integrative level of this complex regulatory network is the hypothalamus [23, 7, 6, 35, 34, 1, 18, 17, 22].

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References

  1. Abramsky O, Wertman E, Reches A, Brenner T, Ovadia H (1987) Effect of hypothalamic lesions on experimental autoimmune diseases in rats. In: Jankovic BD, Markovic BM, Spector NH (eds) Neuroimmune interactions: proceedings of the second international workshop on neuroimmunomodulation. The New York Academy of Sciences, New York, pp 360–365

    Google Scholar 

  2. Adam D, Hahn H, Opferkuch W (eds) (1985) The influence of antibiotics on the host-parasite relationship II. Springer, Berlin Heidelberg New York

    Google Scholar 

  3. Ader R (ed) (1980) Psychoneuroimmunology. Academic, New York

    Google Scholar 

  4. Bishopric NH, Cohen HJ, Lefkowitz RJ (1980) Beta adrenergic receptors in lymphocyte sub-population. J Allergy Clin Immunol 65:29

    Article  PubMed  CAS  Google Scholar 

  5. Boyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 21 [Suppl 97]:77

    CAS  Google Scholar 

  6. Cross RJ, Brooks WH, Roszman TL, Markesbery WR (1982) Hypothalamic-immune interactions. Effect of hypophysectomy on neuroimmunomodulation. J Neurol Sci 53:557

    Article  PubMed  CAS  Google Scholar 

  7. Cross RJ, Markesbery WR, Brooks WH, Roszman TL (1984) Hypothalamic-immune interactions: neuromodulation of natural killer activity by lesioning of the anterior hypothalamus. Immunology 51:399

    PubMed  CAS  Google Scholar 

  8. Eickenberg H-U, Hahn H, Opferkuch W (eds) (1982) The influence of antibiotics on the host-parasite relationship. Springer Berlin Heidelberg New York

    Book  Google Scholar 

  9. Filipp G, Szentivanyi A (1958) Anaphylaxis and the nervous system, part III. Ann Allergy 16:306

    PubMed  CAS  Google Scholar 

  10. Filipp G, Szentivanyi A (1957) Die Wirkung von Hypothalamuslasionen auf den anaphylaktischen Schock des Meerschweinchens. Allergie Asthma 1:23

    CAS  Google Scholar 

  11. Filipp G, Szentivanyi A (1956) Experimentelle Data zur regulativen Rolle des Neuroendo-krinimus in experimenteller Anaphylaxie. I. Relazioni e Communicazioni 229. II Pansiero Scientifico, Rome

    Google Scholar 

  12. Filipp G, Szentivanyi A, Mess B (1952) Anaphylaxis and nervous system. Acta Med Hung III 2:163

    Google Scholar 

  13. Frederickson RCA, Hendrie HC, Hingtgen JN, Aprison MH (eds) (1986) Neuroregulation of autonomic, endocrine and immune systems. Martinus Nijhoff, Boston

    Google Scholar 

  14. Hancock AA, DeLean AL, Lefkowitz RJ (1979) Quantitative resolution of beta-adrenergic receptor subtypes by selective ligand binding: application of a computerized model fitting technique, Mol Pharmacol 16:1

    PubMed  CAS  Google Scholar 

  15. Harper JF, Brooker G (1975) Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2’0 acetylation by acetic anhydride in aqueous solution. J Cyclic Nucleotide Res 1:207

    PubMed  CAS  Google Scholar 

  16. Jankovic BD, Markovic BM, Spector NH (eds) (1987) Neuroimmune interactions: proceedings of the second international workshop on neuroimmunomodulation. The New York Academy of Sciences, New York

    Google Scholar 

  17. Kadlecova O, Masek K, Seifert J, Petrovicky P (1987) The involvement of some brain structures in the effect of immunomodulators. In: Jankovic BD, Markovic BM, Spector NH (eds) Neuroimmune interctions: proceedings of the second international workshop on neuroimmunomodulation. The New York Academy of Sciences, New York, pp 394–398

    Google Scholar 

  18. Katayama M, Kobayashi S, Kuramoto N, Yokoyama MM (1987) Effects ofl hypothalamic lesions on lymphocyte subsets in mice. In: Jankovic BD, Markovic BM, Spector NH (eds) Neuroimmune interactions: proceedings of the second international workshop on neuroimmunomodulation. The New York Academy of Sciences, New York, pp 366–376

    Google Scholar 

  19. Locke S, Ader R, Besedovsky H, Hall N, Solomon G, Strom T (eds) (1985) Foundations of psychoneuroimmunology. Aldine New York

    Google Scholar 

  20. Macris NT, Schiavi RC, Camerino MS, Stein M (1970) Effect of hypothalamic lesions on immune processes in the guinea pig. Am J Physiol 219:1205

    PubMed  CAS  Google Scholar 

  21. Macris NT, Schiavi RC, Camerino MS, Stein M (1972) Effect of hypothalamic lesions on passive anaphylaxis in the guinea pig. Am J Physiol 222:1054

    PubMed  CAS  Google Scholar 

  22. Quirico-Santos T, Valdimarsson H (1987) Modulation of systemic antibody response and tolerance by brain injury. In: Jankovic BD, Markovic BM, Spector NH (eds) Neuroimmune interactions: proceedings of the second international workshop on neuroimmunomodulation. The New York Academy of Sciences, New York, pp 384–387

    Google Scholar 

  23. Roszman TL, Cross RJ, Brooks WH, Markesbery WR (1982) Hypothalamic-immune interactions. II. The effect of hypothalamic lesions on the ability of adherent spleen cells to limit lymphocyte blastogenesis. Immunology 45:737

    PubMed  CAS  Google Scholar 

  24. Steiner AL, Parker CW, Kipnis DM (1972) Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotides. J Biol Chem 247:1106

    PubMed  CAS  Google Scholar 

  25. Szentivanyi A (1961) Hypothalamic influences on antibody formation and on bronchial responses to histamine. Proceedings of the fourth Aspen conference on research in emphysema and asthma, p 48

    Google Scholar 

  26. Szentivanyi A, Filipp G (1958) Anaphylaxis and the nervous system, part II. Ann Allergy 16:143

    PubMed  CAS  Google Scholar 

  27. Szentivany A, Filipp G (1956) Experimentelle Data zur regulativen Rolle des Neuroendokriniums in experimenteller Anaphylaxie. IL Relazioni e Communicazioni 237. II Pansiero Scientifico, Rome

    Google Scholar 

  28. Szentivanyi A, Friedman H, Gillissen G (eds) (1987 a) Antibiosis and host immunity. Plenum, New York

    Google Scholar 

  29. Szentivanyi A, Friedman H, Gillissen G, Szentivanyi J (1987 b) Immunomodulatory effects of some antibiotic-induced changes in bacterial and host determinants. In: Szentivanyi A, Friedman H, Gillissen G (eds) Antibiosis and host immunity. Plenum New York, pp 3–11

    Chapter  Google Scholar 

  30. Szentivanyi A, Szekely J (1958) Anaphylaxis and the nervous system, part IV. Ann Allergy 16:389

    PubMed  CAS  Google Scholar 

  31. Szentivanyi A, Szekely J (1956) Effect of injury to and electrical stimulation of hypothalamic areas on the anaphylactic and histamine shock of the guinea pig. Ann Allergy 14:259

    PubMed  CAS  Google Scholar 

  32. Szentivanyi A, Szekely J (1957d) Über den Effekt der Schädigung und der elektrischen Reizung der hypothalamischen Gegenden auf den anaphylaktischen und Histamin-Schock des Meerschweinchens. Allergie Asthmaforschung Bd 1:28

    Google Scholar 

  33. Szentivanyi A, Szekely J (1957 b) Wirkung der konstanten Reizung hypothalamischer Strukturen durch Tiefenelektroden auf den histaminbedingten und anaphylaktischen Schock des Meerschweinchens. Acta Physiol Hung [Suppl V] Tomus XI:41

    Google Scholar 

  34. Van Oosterhout AJM, Nijkamp FP (1986) Anterior hypothalamic lesions decrease anaphylactic contractions in guinea pig trachea in vitro by reducing histamine and LTC4 reactivity. Int J Immunopharmacol 8(8):975

    Article  PubMed  Google Scholar 

  35. Van Oosterhout AJM, Nijkamp FP (1984) Anterior hypothalamic lesions prevent the endotoxin-induced reduction of beta-adrenoceptor number in guinea pig lung. Brain Res 302–277

    Google Scholar 

  36. Williams LT, Snyderman R, Lefkowitz RJ (1976) Identification of beta-adrenergic receptors in human lymphocytes by (-)[3H]alprenolol binding. J Clin Invest 57:149

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Comprehensive Medicine, University of South Florida College of Medicine, Box 9, Tampa, FL, 33612-4799, USA

    J. Szentivanyi

  2. Departments of Pharmacology and Therapeutics, University of South Florida College of Medicine, Box 9, Tampa, FL, 33612-4799, USA

    A. Szentivanyi

  3. Faculty of Medicine, University of Saarland, Homburg, Federal Republic of Germany

    P. Schultze, G. Filipp & O. Heim

Authors
  1. J. Szentivanyi
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  2. A. Szentivanyi
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  3. P. Schultze
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  4. G. Filipp
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  5. O. Heim
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Editor information

Editors and Affiliations

  1. Institut für Medizinische Mikrobiologie der Medizinischen Fakultät der RWTH Aachen, Pauwelsstrasse, D-5100, Aachen, Germany

    Günther Gillissen

  2. Abteilung für Theoretische und Klinische Medizin Lehrstuhl für Medizinische Mikrobiologie, Ruhr-Universität Bochum, Universitätsstrasse 150, D-4630, Bochum, Germany

    Wolfgang Opferkuch

  3. Hygiene-Institut der Universität zu Köln, Goldenfelsstrasse 19-21, D-5000, Köln 41, Germany

    Georg Peters  & Gerhard Pulverer  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Szentivanyi, J., Szentivanyi, A., Schultze, P., Filipp, G., Heim, O. (1989). Changes in the Immune Parameters of Antibiotic-Bacterial Interactions Induced by Hypothalamic and Other Electrolytic Brain Lesions Produced Through Stereotaxically Implanted Depth Electrodes. In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_33

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  • DOI: https://doi.org/10.1007/978-3-642-73653-7_33

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73655-1

  • Online ISBN: 978-3-642-73653-7

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