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Influence of Mezlocillin Administration to Pregnant Mice on the Immune System of Their Offspring

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The Influence of Antibiotics on the Host-Parasite Relationship III

Abstract

Effects of mezlocillin on the function of the immune system of mice have been demonstrated in previous studies [2, 3, 6, 7]. Experiments performed in vivo revealed that mezlocillin given systemically or orally to Balb/c mice caused a significant depression of the delayed-type hypersensitivity reaction as well as of IgM and IgG responses. This was accompanied by a decrease in the proliferative activity of lymphocytes. Similar treatment with mezlocillin given repeatedly after grafting of murine transplantable tumor (sarcoma L-1) caused a statistically significant prolongation of Balb/c mice survival and reduction of tumor size [2, 3].

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References

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Author information

Authors and Affiliations

  1. Institute of Lung Diseases, Warsaw, Poland

    W. Roszkowski, B. Wesokowska & K. Roszkowski

  2. Hygiene Institute, University of Köln, 5000, Köln, Federal Republic of Germany

    H. L. Ko & G. Pulverer

  3. National Institute of Hygiene, Warsaw, Poland

    P. Ciborowski & J. Jeljaszewicz

Authors
  1. W. Roszkowski
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  2. B. Wesokowska
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  3. H. L. Ko
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  4. K. Roszkowski
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  5. P. Ciborowski
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  6. J. Jeljaszewicz
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  7. G. Pulverer
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Editor information

Editors and Affiliations

  1. Institut für Medizinische Mikrobiologie der Medizinischen Fakultät der RWTH Aachen, Pauwelsstrasse, D-5100, Aachen, Germany

    Günther Gillissen

  2. Abteilung für Theoretische und Klinische Medizin Lehrstuhl für Medizinische Mikrobiologie, Ruhr-Universität Bochum, Universitätsstrasse 150, D-4630, Bochum, Germany

    Wolfgang Opferkuch

  3. Hygiene-Institut der Universität zu Köln, Goldenfelsstrasse 19-21, D-5000, Köln 41, Germany

    Georg Peters  & Gerhard Pulverer  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Roszkowski, W. et al. (1989). Influence of Mezlocillin Administration to Pregnant Mice on the Immune System of Their Offspring. In: Gillissen, G., Opferkuch, W., Peters, G., Pulverer, G. (eds) The Influence of Antibiotics on the Host-Parasite Relationship III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73653-7_32

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  • DOI: https://doi.org/10.1007/978-3-642-73653-7_32

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73655-1

  • Online ISBN: 978-3-642-73653-7

  • eBook Packages: Springer Book Archive

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