Interactions Between Antibiotics, Phagocytes, and Bacteria

  • W. L. Hand
  • N. L. King-Thompson
  • T. H. Steinberg
  • D. L. Hand
Conference paper

Abstract

Antibiotics have biological effects other than direct antimicrobial activity (i.e., other than growth inhibition or killing of organisms). We have been especially interested in the ability of antimicrobial agents to interact with phagocytes and to influence the fate of bacteria ingested by these cells. A major reason for this interest is that survival, and even multiplication, of pathogenic organisms after ingestion by phagocytes may lead to chronic or progressive disease [1,2]. Bacteria which fully exhibit this capability include Mycobacterium tuberculosis and Legionella pneumophila. To a lesser extent many bacteria, including Salmonella and Staphylococcus aureus, can manifest intraphagocytic survival. The efficacy of an antibiotic in therapy of infections, especially those due to facultative intracellular organisms, will depend upon both the extracellular drug-bacterial interaction and the capacity of the antibiotic to penetrate phagocytes and influence the functions of host cells and organisms. Thus, it is important to study the interactions between antibiotics, phagocytes, and bacteria in detail. In an effort to define certain of these interactions we have studied: the uptake of antimicrobial agents by various phagocytic cells, the mechanisms of this entry process for specific antibiotics, the effects of certain factors (phagocytosis, smoking) on drug uptake, the influence of antibiotics on survival of intraphagocytic bacteria, and the consequences of exposure to antibiotics on phagocyte oxidative metabolism.

Keywords

Superoxide Adenosine Cyanide Tetracycline Dextran 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • W. L. Hand
  • N. L. King-Thompson
  • T. H. Steinberg
  • D. L. Hand

There are no affiliations available

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