Influence of RO 236240 on Human Polymorphonuclear Leukocytes In Vitro

  • P. van der Auwera
  • M. Husson
Conference paper


RO 236240 is a new trifluoroquinolone with very high in vitro activity against gram-negative and gram-positive bacteria particularly against methicillin-resistant Staphylococcus aureus. Since staphylococci may behave like intracellular pathogens [1, 2], we have studied the influence of RO 236240 on the functions of polymorphonuclear leukocytes (PMNLs) with a special interest for the intracellular killing.


Minimal Inhibitory Concentration Polymorphonuclear Leukocyte Superoxide Production Phorbol Myristate Acetate Human Polymorphonuclear Leukocyte 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • P. van der Auwera
    • 1
  • M. Husson
    • 1
  1. 1.Service de Médecine et Laboratoire d’Investigation Clinique H. J. TagnonInstitut Jules Bordet, Centre des Tumeurs de l’Université Libre de BruxellesBrusselsBelgium

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