Influence of RO 236240 on Human Polymorphonuclear Leukocytes In Vitro
RO 236240 is a new trifluoroquinolone with very high in vitro activity against gram-negative and gram-positive bacteria particularly against methicillin-resistant Staphylococcus aureus. Since staphylococci may behave like intracellular pathogens [1, 2], we have studied the influence of RO 236240 on the functions of polymorphonuclear leukocytes (PMNLs) with a special interest for the intracellular killing.
KeywordsMinimal Inhibitory Concentration Polymorphonuclear Leukocyte Superoxide Production Phorbol Myristate Acetate Human Polymorphonuclear Leukocyte
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