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Autosomal Dominant Ichthyosis Vulgaris

  • Heiko Traupe

Abstract

Alibert [1] is credited with the first description of autosomal dominant ichthyosis vulgaris (ADI) under the designation “ichthyose nacrée.“ Peukert [14] noted the frequent familial occurrence of the disease and concluded that it was inherited as a dominant trait. A number of reports in the older literature mention that ADI seems frequently to skip a generation [13]. The skipping of a generation is typical for X-linked recessive inheritance, and in a number of families in which skipping of ichthyosis vulgaris is mentioned in the literature the disease may in fact have been X-linked recessive ichthyosis (XRI). The clinical and genetic features of ADI could be fully appreciated only after XRI had been delineated by Wells and Kerr [20, 21].

Keywords

Atopic Dermatitis Stratum Corneum Granular Layer Keratin Filament Keratosis Follicularis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Heiko Traupe
    • 1
  1. 1.Department of Human GeneticsUniversity of NijmegenHB NijmegenThe Netherlands

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