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Etiology Versus Pathogenesis: The Causes of Post-Translational Modifications of Host-Specified Brain Proteins to Amyloid Configuration

  • D. C. Gajdusek
Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Abstract

Since amyloid is deposited as neurofibrillary tangles, plaques, and vascular amyloid in brains of all the very aged (> 90 years), and this amyloid is biochemically the same as that in Alzheimer’s disease, Down’s syndrome, and Guamanian amyotrophic lateral sclerosis/Parkinsonism-dementia (ALS/PD), we know that no abnormal hereditable gene is necessary for such deposition. By isolating the gene for the precursor to this amyloid we are surely tracking pathogenesis of normal aging. Alzheimer’s disease, Down’s syndrome, and Guamanian ALS/PD. The same applies to isolating the gene for the normal host precursor protein for the much different amyloid of the scrapie-associated fibrils of unconventional viruses (scrapie-kuru-Creutzfeldt-Jakob disease) and the amyloid plaques of these diseases.

Keywords

Neurofibrillary Tangle Amyloid Fibril Acta Pathol Cerebrovascular Amyloid Amyloid Enhance Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 1988

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  • D. C. Gajdusek

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