Etiology Versus Pathogenesis: The Causes of Post-Translational Modifications of Host-Specified Brain Proteins to Amyloid Configuration
Since amyloid is deposited as neurofibrillary tangles, plaques, and vascular amyloid in brains of all the very aged (> 90 years), and this amyloid is biochemically the same as that in Alzheimer’s disease, Down’s syndrome, and Guamanian amyotrophic lateral sclerosis/Parkinsonism-dementia (ALS/PD), we know that no abnormal hereditable gene is necessary for such deposition. By isolating the gene for the precursor to this amyloid we are surely tracking pathogenesis of normal aging. Alzheimer’s disease, Down’s syndrome, and Guamanian ALS/PD. The same applies to isolating the gene for the normal host precursor protein for the much different amyloid of the scrapie-associated fibrils of unconventional viruses (scrapie-kuru-Creutzfeldt-Jakob disease) and the amyloid plaques of these diseases.
KeywordsNeurofibrillary Tangle Amyloid Fibril Acta Pathol Cerebrovascular Amyloid Amyloid Enhance Factor
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- Axelrad MA, Kisilevsky R (1980) Biological characterizations of amyloid enhancing factor. In: Glenner GG, Costa PP, de Freitas AF (eds) Amyloid and amyloidosis. Excerpta Medica, Amsterdam, pp 527–533Google Scholar
- Beyreuther K, Multhaup G, Simms G, Pottgiesser J, Schroeder W, Martins RN, Masters CL (1986) Neurofibrillary tangles of Alzheimer’s disease and "aged" Down’s syndrome contain the same protein as the amyloid of plaque cores and blood vessels. Disc Neurosci 3: 68–79Google Scholar
- Guiroy DC, Miyazaki M, Multhaup G, Fischer P, Garruto RM, Beyreuther K, Masters CL, Simms G, Gibbs CJ, Jr, Gajdusek DC (1987) Amyloid of the neurofibrillary tangles of Guamanian parkinsonism-dementia and Alzheimer disease share identical amino acid sequence. Proc Natl Acad Sci USA 84: 2073–2077PubMedCrossRefGoogle Scholar
- Keizman I, Rimon A, Sohar E, Gafni J (1972) Amyloid accelerating factor. Acta Pathol Microbiol Scand [Suppl 233] 80:172–177Google Scholar
- Teilum G (1964) Pathogenesis of amyloidosis. The two-phase cellular theory of local secretion. Acta Pathol Microbiol Scand 61: 21–45Google Scholar
- Werderlin O, Ranlov P (1966) Amyloidosis in mice produced by transplantation of spleen cells from casein-treated mice. Arch Pathol Microbiol Scand 68: 1–18Google Scholar