Abstract
It has been demonstrated that bone blood flow is under neuro-humeral control (Gross et al. 1979), but the effect of these control mechanisms on mineral exchange processes has not been examined so thoroughly. Transcapillary exchange in bone is by passive diffusion (Kelly and Bassingthwaighte 1977), and we have demonstrated that blood flow rate through the microcirculation in bone decreases the extraction of methylene diphosphonate in a known and predictable way (McCarthy and Hughes 1983). It was found that permeability surface area (PS) remained constant during increased flow rate through the tibia. In the present series of experiments, we wished to examine whether increased vascular resistance in bone, due to the administration of noradrenaline, would decrease the value of PS in bone.
This work was funded by a grant from the Medical Research Council.
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References
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© 1990 Springer-Verlag Berlin Heidelberg
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Hughes, S.P.F., McCarthy, I.D. (1990). The Effects of Noradrenaline on Perfusion Pressure and Capillary Permeability-Surface Area Product in the Canine Tibia. In: Arlet, J., Mazières, B. (eds) Bone Circulation and Bone Necrosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73644-5_9
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DOI: https://doi.org/10.1007/978-3-642-73644-5_9
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