Is There A Blood-Bone Barrier?

  • I. D. McCarthy
  • S. P. F. Hughes
Conference paper

Abstract

The nature of the extravascular extracellular space in bone may play an important role in the control of mass transport in bone. Do the cells lining bone surfaces control the fluid environment adjacent to bone surfaces so that its composition is different to perivascular fluid? This question has been discussed for some years, but experimental evidence has not been conclusive. Neuman published a series of papers concerned with blood-bone disequilibrium or blood-bone equilibrium (Neuman 1982; Neuman et al. 1979), and Talmage (1977) has also proposed disequilibrium between blood and bone. To investigate this problem, we have used techniques already used in the study of trans-capillary exchange to investigate whether transport of ions from the perivascular bone fluid can be controlled by cells lining bone surfaces.

Keywords

Albumin Cyanide Kelly 85Sr 86Rb 

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References

  1. Hooper G, McCarthy ID, Wooton R, Hughes SPF (1984) Fluid spaces in the canine tibia In: Arlet J, Ficat RP, Hungerford DS (eds) Bone circulation. Williams and Wilkins, Baltimore, p 2004Google Scholar
  2. Kelly PJ, Bassingthwaighte JB (1977) Studies on bone ion exchanges using multiple-tracer indicator-dilution techniques. Fed Proc 36:2634–2639PubMedGoogle Scholar
  3. Neuman MW (1982) Blood: bone equilibrium Calcif Tissue Int 34:117–120PubMedCrossRefGoogle Scholar
  4. Neuman WF, Neuman MW, Myers CR (1979) Blood: bone disequilibrium. III Linkage between cell energetics and Ca fluxes. Am J Physiol 236:C244–C248PubMedGoogle Scholar
  5. Talmage RV (1971) Morphological and physiological considerations in a new concept of calcium transport in bone. Am J Anat 129:467–476CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • I. D. McCarthy
  • S. P. F. Hughes

There are no affiliations available

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