Abstract
Multiple tracer outflow dilution (MTOD) experiments have been performed in our laboratories to study such exchange in which 125I-labelled albumin reference and 85Sr (Ca analogue), 86Rb (K analogue) diffusible tracers were injected together into Krebs-Ringer bicarbonate buffer which was infused through the tibial nutrient artery at a physiological rate of 2 ml/min; outflow samples were taken simultaneously every 5 s from the ipsilateral femoral vein over a period of 5 min (McCarthy and Hughes 1986).
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References
Bassingthwaighte JB, Goresky CA (1984) Modelling in the analysis of solute and water exchange in the microvasculature. In: Handbook of physiology. Renkin EH, Michel CC (eds) the cardiovascular system. IV. American Physiological Society, Bethesda, pp 549–626
Kelly PJ, Bassingthwaighte JB (1977) Studies on bone ion exchanges using multiple-tracer indicator-dilution techniques. Fed Proc 36(12):2634–2639
Kuikka J, Levin M, Bassingthwaighte JB (1986) Multiple tracer dilution estimates of D- and 2-deoxy-D-glucose uptake by the heart. Am J Physiol 250:H29–H42
Lopez-Curto JA, Bassingthwaighte JB, Kelly PJ (1980) Anatomy of the micro vasculature of the tibial diaphysis of the adult dog. J Bone Joint Surg [Am] 62A:1362–1369
McCarthy ID, Hughes SPF (1986) Inhibition of bone cell metabolism increases strontium-85 uptake. Calcif Tissue Int 39:386–389
Tothill P, Hooper G, McCarthy ID, Hughes SPF (1987) The pattern of distribution of blood flow in dog limb bones measured using microspheres. Clin Phys Physiol Meas 8:239–248
Willans SM, McCarthy ID (1986) Distributed model of blood-bone exchange. J Biomed Eng 8:235–243
Willans SM (1987) Modelling in the analysis of ion exchange between blood and bone. PhD thesis, University of Edinburgh
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© 1990 Springer-Verlag Berlin Heidelberg
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Willans, S.M., Hughes, S.P.F., McCarthy, I.D. (1990). A Multicapillary Distributed Model of Blood-Bone Exchange to Analyse Multiple Tracer Outflow Dilution Data. In: Arlet, J., Mazières, B. (eds) Bone Circulation and Bone Necrosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73644-5_6
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DOI: https://doi.org/10.1007/978-3-642-73644-5_6
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