Anemia, But Not Stimulation of Erythropoiesis Without Anemia, Increases Bone and Bone Marrow Blood Flow in the Rat
Anemia induces several bone modifications, hyperplasia of hematopoetic tissue, increased bone marrow blood flow, release of immature cells from bone marrow, and resorption of bone [1–5]. The aim of study was to investigate whether the extension of the bone marrow cellular mass was the causal factor in inducing the increase in bone blood flow.
KeywordsBone Marrow Hemolytic Anemia Bone Blood Flow Bone Marrow Tissue Bone Modification
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Chen LT, Chen MF, Porter VL (1986) Increased bone marrow blood flow in rabbits with acute hemolytic anemia. Am J Hematol 22:35–41PubMedCrossRefGoogle Scholar
Michelsen K (1969) Hemodynamics in the bone marrow of anemic rabbits with increased hematopoiesis. Acta Physiol Scand 77:52–57PubMedCrossRefGoogle Scholar
Syftestad GT, Boelkins JN (1980) Effect of hemorrhage on blood flow to marrow and osseous tissue in conscious rabbits. Am J Physiol 238 (Heart Circ Physiol 7):H360-H364PubMedGoogle Scholar
Gross PM, Heistad DD, Marcus ML (1979) Neurohumoral regulation of blood flow to bone marrow. Am J Physiol 237 (4):H440-H448PubMedGoogle Scholar
McClugage (1973) Relationship of the microvascular system to bone resorption and growth in situ. Micro vase Res 6:132–134CrossRefGoogle Scholar
Feleppa AE, Meineke HA, McCuskey RS (1971) Studies of transplanted haematopoietic tissue utilizing a modified algire back chamber. Scand J Haematol 8:86–91PubMedCrossRefGoogle Scholar
Knighton DR, Hunt TK, Scheuenstuhl H, Halliday BJ (1983) Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science 221:1283–1285PubMedCrossRefGoogle Scholar
Guyton AC, Ross JM, Carrier O, Walker Jr MS (1964) Evidence for tissue oxygen demand as the major factor causing autoregulation. Circ Res XIV/XV (Suppl 1):1.60–1.69Google Scholar
© Springer-Verlag Berlin Heidelberg 1990