Abstract
Osteoporosis paradoxically represents a metabolic bone disorder without obviously abnormal metabolism or structural decomposition of the bone. Its pathogenesis is unclear, prevention unsafe and therapeutic restitution unachievable. Aplastic anaemia is considered to arise either from a defect of a primitive haematopoietic stem cell, from a deficiency of its stromal microenvironment or from disturbed interaction of both [2, 6]. Its cause is unexplained in the majority of patients, and cure is hopeless in many cases. Now, old age notoriously may also induce bone changes similar to osteoporosis as atrophy of the bone marrow similar to aplastic anaemia. Senility, as such, in spite of the elucidation of many partial aspects, remains enigmatic. In this study, changes of the common structural microenvironment are presented that might be involved in the pathogenesis of the three conditions.
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© 1990 Springer-Verlag Berlin Heidelberg
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Burkhardt, R. (1990). Bone Marrow Microcirculation in Primary Osteoporosis, Aplastic Anaemia, and Old Age. In: Arlet, J., Mazières, B. (eds) Bone Circulation and Bone Necrosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73644-5_14
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DOI: https://doi.org/10.1007/978-3-642-73644-5_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73646-9
Online ISBN: 978-3-642-73644-5
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