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Dose-Dependent Reduction of Bone Blood Flow and 85Sr Clearance Caused by Prostaglandin E2

  • E. Cochrane
  • R. H. Fleming
  • I. D. McCarthy

Abstract

Osteolytic effects of series E prostaglandins are well established in vitro and in vivo (Klein and Raisz 1970; Vanderwiel and Talmage 1979), and it has also been reported that the injection of massive doses of native prostaglandin E2 (PGE2) into rats can enhance bone mineralisation (Uemo et al. 1984). Recent reports have claimed that 16–16 dimethyl PGE2 produced inhibition of 45Ca uptake in chicks. It was suggested that this represented a novel response, but the possibility of an indirect vascular mechanism was also discussed. In this paper, we have investigated the relationship between the inhibition of mineral uptake by PGE2 and changes in bone blood flow. This has then been compared with the response due to the vasoactive effect of noradrenaline.

Keywords

Dose Group Reduce Blood Flow 45Ca Uptake Concentration Of80 Tail Artery 
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References

  1. Klein DC, Raisz LE (1970) Prostaglandins: stimulation of bone resorption in tissue culture. Endocrinology 86:1436–1449PubMedCrossRefGoogle Scholar
  2. Schoutens A, Bergmann P, Verihas M (1979) Bone blood flow measured by 85Sr microspheres and bone seeker clearances in the rat. Am J Physiol 236:H1–H6PubMedGoogle Scholar
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  4. Uemo K, Kimmel DB, Jee WAA (1984) In: Cohn DV, Fujita T, Potts JT, Talmage RV (eds) Proceedings VIII international conference on calcium regulating hormones, Kobe, 1983. Excerpta Medica, Amsterdam, pp 151–154Google Scholar
  5. Vanderweil EJ, Talmage RV (1979) Comparison of the effects of prostaglandin E2 and PTH on plasma calcium concentration and osteoclast function. Endocrinology 105:588–594CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • E. Cochrane
  • R. H. Fleming
  • I. D. McCarthy

There are no affiliations available

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