Abstract
Coptis rhizome (Japanese name woren), belonging to the Ranunclaceae, is very commonly used in Japanese traditional medicine as antipyretic, antidote and antidysentery. The cultivation of the rhizome of Coptis plant grows very slowly and takes 5–6 years before use as raw material or as a source of berberine from the rhizome. Its rootstock and fibrous roots contain much berberine and other minor protoberberine alkaloids. Berberine is an useful antibacterial agent, and has stomachic and anti-inflammatory effects. Berberine can be obtained from Coptis rhizome and Phellodendron bark and has a wide market in Japan and East Asia.
It is of pharmaceutical significance to investigate callus culture of this plant for berberine production. Several researchers have been working on its production (Table 1).
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References
Chadha YR (ed) (1976) Wealth of India raw materials, vol 2. CSIR, New Delhi.
Cooper SF, Mockie JA, Beliveau J (1970) Alkaloids of Coptis groenlandica. Planta Med 19: 23–29.
Fujita Y, Tabata M, Nishi A, Yamada Y (1982) New medium and production of secondary compounds with the two-staged culture method. In: Fujiwara A (ed) Plant tissue culture 1982. Maruzen, Tokyo, pp 399–400.
Fukui H, Nakagawa K, Tsuda S, Tabata M (1982) Production of isoquinoline alkaloids by cell suspension cultures. In: Fujiwara A (ed) Plant tissue culture 1982. Maruzen, Tokyo, pp 313–314.
Furuya T, Syōno K, Ikuta A (1972) Isolation of berberine from callus tissue of Coptis japonica. Phytochemistry 11: 175.
Ikuta A, Itokawa H (1982a) Berberine and other protoberberine alkaloids in callus tissue of Thalictrum minus. Phytochemistry 21: 1419–1421.
Ikuta A, Itokawa H (1982 b) Studies on the alkaloids from tissue culture of Nandina domestica. In: Fujiwara A (ed) Plant tissue culture 1982. Maruzen, Tokyo, pp 315–316.
Ikuta A, Itokawa H (1983) Alkaloids of Coptis rhizome. J Nat Prod 38: 189–190.
Ikuta A, Itokawa H (1988) Berberine: Production through plant (Thalictrum spp.) cell cultures. In: Bajaj YPS (ed) Biotechnology in agriculture and forestry, vol 4. Medicinal and Aromatic plants I. Springer, Berlin Heidelberg New York Tokyo, pp 282–293.
Ikuta A, Syōno K, Furuya T (1974) Alkaloids of callus tissues and redifferentiated plantlets in the Papaveraceae. Phytochemistry 13: 2175–2179.
Ikuta A, Syōno K, Furuya T (1975) Alkaloids in plants regenerated from Coptis callus cultures. Phytochemistry 14:1209–1210.
Ikuta A, Kobayashi A, Itokawa H (1984) Studies on the quantitative of protoberberine alkaloids in Japan, China and other countries; rhizomes by thin layer chromatograph-densitometry. Shoyakugaku Zasshi 38: 279–282.
Kamo KK, Kimoto W, Hsu AF, Mahlberg PG, Bills DD (1982) Morphinane alkaloids in cultured tissue and redifferentiated organs of Papaver somniferum. Phytochemistry 21: 219–222.
Kirtikar KR, Basu BS, An ICS (eds) (1935) Indian medicinal plants. Int Book Distrib Book sellers, Dehra Dun, India, pp 18–19 (vol I)
Linsmaier EM, Skoog F (1965) Organic growth factor requirements of tobacco tissue cultures. Physiol Plant 18: 100–127.
Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473–497.
Nakagawa K, Konagi A, Fukui H, Tabata M (1984) Release and crystallization of berberine in the liquid medium of Thalictrum minus cell suspension cultures. Plant Cell Rep 3: 254–257.
Perry LM, Metzger J (1980) Medicinal plants of east and southeast asia. Attributed properties and uses. MIT, London, Cambridge, Mass., pp 335–336.
Sato F, Yamada Y (1984) High berberine-producing cultures of Coptis japonica cells. Phytochemistry 23: 281–285.
Syōno K, Furuya T (1972) The differentiation of Coptis plants in vitro from callus cultures. Experientia 28: 236.
Tamura M (1982) Ranunculaceae. In: Satake Y, Ohwi J, Kitamura S, Watari S, Tominari T (eds) Wild flowers of Japan II. Herbaceous plants. Heibonsha, Tokyo, pp 54–87.
Walter HL, Memony PF, Elvin L (eds) (1977) Medical botany: plants affecting man’s health. Wiley-Interscience, New York.
Yamada Y, Okada N (1985) Biotransformation of tetrahydroberberine to berberine by enzymes prepared from cultured Coptis japonica cells. Phytochemistry 24: 63–65.
Yamada Y, Sato F (1981) Production of berberine in cultured cells of Coptis japonica. Phytochemistry 20: 545–547.
Yamamoto H (1980) Effect of berberine on growth of the callus cultures of several species. Bot Mag (Tokyo) 93: 307–315.
Yamamoto H, Tomimori T (1981a) Studies of the fundamental conditions on growth and alkaloid formation of the callus cultures of Coptis japonica var. japonica (I). Shoyakugaku Zasshi 35: 1–8.
Yamamoto H, Tomimori T (1981b) Studies of the fundamental condition on growth and alkaloid formation of the callus cultures of Coptis japonica var. japonica (II). Shoyakugaku Zasshi 35: 9–14.
Yamamoto H, Ishida M, Tomimori T (1981) Studies of the fundamental conditions on growth and alkaloid formation of the callus cultures of Coptis japonica var. japonica (III). Effects of cloning and mutagens. Shoyakugaku Zasshi 35: 15–21.
Yoshikawa T, Furuya T (1985) Morphinane alkaloid production by tissues differentiated from cultured cells of Papaver somniferum (I). Planta Med 42: 110–113.
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Ikuta, A., Itokawa, H. (1989). Coptis: In Vitro Regeneration of Plants and the Production of Berberine. In: Bajaj, Y.P.S. (eds) Medicinal and Aromatic Plants II. Biotechnology in Agriculture and Forestry, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73617-9_7
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DOI: https://doi.org/10.1007/978-3-642-73617-9_7
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