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Persistence of Enterovirus RNA in Dilated Cardiomyopathy: A Progression from Myocarditis

  • L. C. Archard
  • C. A. Freeke
  • P. J. Richardson
  • B. Meany
  • E. G. J. Olsen
  • P. Morgan-Capner
  • M. L. Rose
  • P. Taylor
  • N. R. Banner
  • M. H. Yacoub
  • N. E. Bowles

Abstract

We have investigated the role of enterovirus infection in the pathogenesis of myocarditis and dilated cardiomyopathy. In this article we will present evidence (from molecular hybridizations with virus-specific probes) that enteroviruses are major aetiological agents of myocarditis and dilated cardiomyopathy and that virus persistence in myocardium is implicated in the progression from myocarditis to dilated cardiomyopathy.

Keywords

Dilate Cardiomyopathy Viral Myocarditis Acute Myocarditis Explanted Heart Defective Interfere 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • L. C. Archard
    • 1
  • C. A. Freeke
    • 1
  • P. J. Richardson
    • 2
  • B. Meany
    • 2
  • E. G. J. Olsen
    • 3
  • P. Morgan-Capner
    • 4
  • M. L. Rose
    • 5
  • P. Taylor
    • 5
  • N. R. Banner
    • 5
  • M. H. Yacoub
    • 5
  • N. E. Bowles
    • 1
  1. 1.Department of BiochemistryCharing Cross and Westminster Medical SchoolLondonUK
  2. 2.Cardiac DepartmentKings College HospitalLondonUK
  3. 3.Histology DepartmentNational Heart HospitalLondonUK
  4. 4.Preston InfirmaryDistrict LaboratoryPrestonUK
  5. 5.Harefield HospitalHarefield, MiddlesexUK

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