Viral Myocarditis: Immunogenetic and Autoimmune Aspects

  • K. W. Beisel
  • M. D. Traystman


Chronic inflammatory heart disease has been suggested as a sequela of infection by a variety of microbial agents in man [31]. Several lines of evidence suggest that myocardial autoimmunity is the major pathogenic mechanism in chronic inflammation of the myocardium. Maisch et al. [15] have demonstrated that patients with viral myocarditis develop autoantibodies to cardiac contractile and sarcolemmal proteins. Cardiac-specific autoantibodies to the mitochondrial adenosine di-/triphosphate (ADP/ATP) translocator protein have also been identified in patients with dilated cardiomyopathy [24]. This relationship between viral heart disease and myocardial autoimmunity has been documented using the mouse model. The presence of heart-specific autoantibodies and chronic, late-phase myocarditis suggest that a sequela of coxsackievirus type B3 (CVB3)-induced myocarditis in mice is an autoimmune-based disease [30]. Other findings similarly support the involvement of humoral and cellular autoimmune mechanisms in the pathogenesis [10, 14].


Recombinant Inbred Viral Myocarditis Cardiac Myosin Recombinant Inbred Strain CVB3 Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • K. W. Beisel
    • 1
  • M. D. Traystman
    • 2
  1. 1.Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Department of PediatricsThe Johns Hopkins University School of MedicineBaltimoreUSA

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