Viral Myocarditis: Immunogenetic and Autoimmune Aspects

  • K. W. Beisel
  • M. D. Traystman

Abstract

Chronic inflammatory heart disease has been suggested as a sequela of infection by a variety of microbial agents in man [31]. Several lines of evidence suggest that myocardial autoimmunity is the major pathogenic mechanism in chronic inflammation of the myocardium. Maisch et al. [15] have demonstrated that patients with viral myocarditis develop autoantibodies to cardiac contractile and sarcolemmal proteins. Cardiac-specific autoantibodies to the mitochondrial adenosine di-/triphosphate (ADP/ATP) translocator protein have also been identified in patients with dilated cardiomyopathy [24]. This relationship between viral heart disease and myocardial autoimmunity has been documented using the mouse model. The presence of heart-specific autoantibodies and chronic, late-phase myocarditis suggest that a sequela of coxsackievirus type B3 (CVB3)-induced myocarditis in mice is an autoimmune-based disease [30]. Other findings similarly support the involvement of humoral and cellular autoimmune mechanisms in the pathogenesis [10, 14].

Keywords

Fractionation Serine Cardiomyopathy Cardiol Gelatin 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • K. W. Beisel
    • 1
  • M. D. Traystman
    • 2
  1. 1.Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Department of PediatricsThe Johns Hopkins University School of MedicineBaltimoreUSA

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