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Kaposi’s Sarcoma: A Cytogenetic Study

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New Frontiers in Cytology

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Abstract

There are in the literature only two specific studies about the cytogenetic analysis of Kaposi’s Sarcoma (KS). The first [2] was based on 11 untreated KS patients. Lymphocyte cultures were made in all of these cases, fibroblast cultures additionally in five. The authors defined clonal evolution as the presence of at least two cells with the same numerical or structural aberration in the same culture, and their lymphocyte analysis showed clonal evolution in six of eleven cases. Additionally, in fibroblast cultures from two sarcomatous lesions they found seven cells in the first with 47, XXY and t (7; 13) in the second. The authors suggested that the chromosomal instability found in KS patients may be associated with an oncogenic virus.

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References

  1. Dalli Bovi P, Donti E, Knowles II DM, Friedman-Kien A, Luciw PA, Dina D, Delia Favera R, Basilico C (1986) Presence of chromosomal abnormalities and lack of AIDS retrovirus DNA sequences in AIDS-associated Kaposi’s sarcoma. Cancer Res 46: 6333–6338

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  2. Scappaticci S, Cerimele D, Cottoni F, Pasquali F, Fraccaro M (1986) Chromosomal aberrations in lymphocytes and fíbroblast cultures of patients with the sporadic type of Kaposi’s sarcoma. Hum Genet 72: 311–317

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Authors
  1. P. Grammatico
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  2. A. M. Cianciulli
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  3. I. Venturo
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  4. S. Campo
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  5. R. Perrone Donnorso
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  6. G. Del Porto
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Editor information

Editors and Affiliations

  1. Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-6900, Heidelberg, Federal Republic of Germany

    Klaus Goerttler

  2. Institut für Vergleichende und Experimentelle Pathologie der Universität, Im Neuenheimer Feld 220-221, D-6900, Heidelberg, Federal Republic of Germany

    Georg E. Feichter

  3. Abteilung Innere Medizin, Diakonissenhospital, D-7500, Karlsruhe, Federal Republic of Germany

    Siegfried Witte

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© 1988 Springer-Verlag Berlin Heidelberg

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Grammatico, P., Cianciulli, A.M., Venturo, I., Campo, S., Donnorso, R.P., Del Porto, G. (1988). Kaposi’s Sarcoma: A Cytogenetic Study. In: Goerttler, K., Feichter, G.E., Witte, S. (eds) New Frontiers in Cytology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73596-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-73596-7_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73598-1

  • Online ISBN: 978-3-642-73596-7

  • eBook Packages: Springer Book Archive

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