Correlations of Malignancy in Cultured Cells
Normal tissues are under strict growth control (G- phenotype). Benign tumours differ from normal tissues by loss of growth control (G+ phenotype), but they are not invasive (I- phenotype) and not metastatic (M- phenotype). Malignant tumours also display the G+ phenotype, but at least part of their cell populations have acquired invasive (I+ phenotype) and metastatic (M+ phenotype) capabilities. We infer from these well-documented clinical and pathological observations that invasion and metastasis, more than loss of growth control, are the hallmarks of malignancy. Obviously, this does not mean that uncontrolled growth does not contribute to the progression of the disease.
KeywordsTissue Culture Plastic Cellular Adhesion Molecule Mock Cell Chick Heart Acceptor Cell
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