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Immunmodulierende Eigenschaften von Faktor VIII-Konzentraten

  • J. W. Mannhalter
  • J. Göttlicher
  • H. Leibl
  • H. M. Wolf
  • M. M. Eibl
Conference paper

Zusammenfassung

Das Auftreten therapiemediierter Nebenreaktionen bei der Behandlung von Hämophilie-Patienten ist ein lange bekanntes Problem. Während bei Infusionen von Faktor VIII-Präparaten unmittelbare adverse Reaktionen selten vorkommen [1–6], spielen Langzeit-Nebeneffekte wie z. B. Hypertonie [7], Hämolyse [8–10], Thrombozytopenie [11, 12], die Bildung von Faktor VIII-Inhibitoren [13, 14], sowie durch kontaminierende Viren hervorgerufene Erkrankungen (Non-A/Non-B-Hepatitis, AIDS) [15–21] eine wesentliche Rolle bei der Morbidität und Mortalität dieser Patientengruppe. Das Auftreten der Nebeneffekte kann zum Teil auf kontaminierende Proteine wie Isoagglutinine, Fibrinogen, Immunglobuline, Immunkomplexe und Immunglobulinaggregate zurückgeführt werden [7, 22, 23].

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • J. W. Mannhalter
    • 1
  • J. Göttlicher
    • 1
  • H. Leibl
    • 1
  • H. M. Wolf
    • 1
  • M. M. Eibl
    • 1
  1. 1.Wien, OrthÖsterreich

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