Effects of Sucrose Meal on Insulin Requirement in IDDM and its Modulation by Acarbose
We have studied in patients with insulin-dependent diabetes mellitus (IDDM) the effects of a sucrose meal on glucose gut absorption, glucose turnover, insulin requirement, and the modulation of the latter by a disaccharidase inhibitor, acarbose. Each subject (n = 5) was studied after an overnight fast during a sucrose meal of 50, 75 and 100 g with and without acarbose. Normoglycemia was maintained by the artificial pancreas. In three subjects gut absorption and glucose turnover were measured during the 75-g sucrose load.