Effects of Acarbose on Cardiac and Hepatic Metabolism in Diabetic Rats
We have studied the effects of the inclusion of acarbose in a high carbohydrate diet fed to rats with type I diabetes (streptozotocin-treated) and to rats with genetically induced type II diabetes (SHR/N-cp rats). Although the SHR/N-cp rats had only a slightly elevated fasting blood sugar, the oral glucose tolerance curve in these rats was markedly higher than that in normal rats. Administration of acarbose for 5 weeks (10 mg/100 g diet) greatly improved glucose tolerance in the type II diabetic antimals. In streptozotocin-diabetic rats, in which fasting blood sugar was extremely high, feeding of acarbose had little or no effect on the hyperglycemia.