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Effects of Acarbose on Cardiac and Hepatic Metabolism in Diabetic Rats

  • M. E. Hess
  • N. Haugaard
  • A. Torbati
  • A. Rastogi
  • O. L. Tulp
Conference paper

Abstract

We have studied the effects of the inclusion of acarbose in a high carbohydrate diet fed to rats with type I diabetes (streptozotocin-treated) and to rats with genetically induced type II diabetes (SHR/N-cp rats). Although the SHR/N-cp rats had only a slightly elevated fasting blood sugar, the oral glucose tolerance curve in these rats was markedly higher than that in normal rats. Administration of acarbose for 5 weeks (10 mg/100 g diet) greatly improved glucose tolerance in the type II diabetic antimals. In streptozotocin-diabetic rats, in which fasting blood sugar was extremely high, feeding of acarbose had little or no effect on the hyperglycemia.

Keywords

Hepatic Metabolism Glycogen Content Fast Blood Sugar Improve Glucose Tolerance High Carbohydrate Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. E. Hess
    • 1
    • 2
  • N. Haugaard
    • 1
    • 2
  • A. Torbati
    • 1
    • 2
  • A. Rastogi
    • 1
    • 2
  • O. L. Tulp
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Nutrition and Food ScienceDrexel UniversityPhiladelphiaUSA

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