Effects of Acarbose on Cardiac and Hepatic Metabolism in Diabetic Rats

  • M. E. Hess
  • N. Haugaard
  • A. Torbati
  • A. Rastogi
  • O. L. Tulp
Conference paper

Abstract

We have studied the effects of the inclusion of acarbose in a high carbohydrate diet fed to rats with type I diabetes (streptozotocin-treated) and to rats with genetically induced type II diabetes (SHR/N-cp rats). Although the SHR/N-cp rats had only a slightly elevated fasting blood sugar, the oral glucose tolerance curve in these rats was markedly higher than that in normal rats. Administration of acarbose for 5 weeks (10 mg/100 g diet) greatly improved glucose tolerance in the type II diabetic antimals. In streptozotocin-diabetic rats, in which fasting blood sugar was extremely high, feeding of acarbose had little or no effect on the hyperglycemia.

Keywords

Sugar Carbohydrate Catecholamine Triglyceride Hyperglycemia 

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. E. Hess
    • 1
    • 2
  • N. Haugaard
    • 1
    • 2
  • A. Torbati
    • 1
    • 2
  • A. Rastogi
    • 1
    • 2
  • O. L. Tulp
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Nutrition and Food ScienceDrexel UniversityPhiladelphiaUSA

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