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Corticoid-Verdünnungen

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Neue Entwicklungen in der Dermatologie

Zusammenfassung

Die rezepturmäßige Verdünnung stark wirkender Corticoid-Dermatica des Handels ist zu einem von Ärzten, Apothekern und Arzneifabrikanten heftig umstrittenen Thema geworden. Es wird der Versuch einer Sichtung der Publikationen unternommen, die sich mit dem Thema beschäftigen und die Pro und Contra dieser Praxis zur Diskussion stellen. So werden nach einer Begründung der Rezeptur von Verdünnungen deren galenische, biopharmazeutische, chemische und mikrobiologische Aspekte besprochen. Schließlich wird auf Alternativlösungen hingewiesen, die der Erhöhung der Therapiesicherheit dienen.

Summary

Prescription of potent topical corticoid preparations diluted with various vehicles has become an issue of disputation among physicians, pharmacists, and pharmaceutical firms. The recent literature on this problem is reviewed and discussed with particular respect of the reasons of “pro” and “contra” of this prescriptive practice in medicine. Various risky aspects of dilutory formulation with regard to pharmaceutics, biopharmaceutics, chemistry, and microbiology are pointed out. Some alternative proposals to improve the safety of therapy is presented.

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Authors and Affiliations

  1. Dr. Spirig AG, Pharmazeutische Präparate, Olten, Schweiz

    K. H. Müller

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  1. K. H. Müller
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Editor information

Editors and Affiliations

  1. Erlangen, Deutschland

    O. P. Hornstein

  2. Münster-Hornheide, Deutschland

    M. Hundeiker

  3. Mannheim, Deutschland

    J. Schönfeld

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Müller, K.H. (1988). Corticoid-Verdünnungen. In: Hornstein, O.P., Hundeiker, M., Schönfeld, J. (eds) Neue Entwicklungen in der Dermatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73581-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-73581-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19142-1

  • Online ISBN: 978-3-642-73581-3

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