Zusammenfassung
Der Begriff „hepatische Enzephalopathie“ beschreibt alle neuropsychiatrischen Syndrome, die bei akuten oder chronischen Lebererkrankungen auftreten können. Die hepatische Enzephalopathie ist kein einheitliches Krankheitsbild, ein genaueres Verständnis ihrer Pathogenese and eine etablierte Therapie sind in weiter Ferne.
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Literatur
Al Mardini H, Bartlett K, Record CO (1984) Blood and brain concentrations of mercaptans in hepatic and methanethiol induced coma. Gut 25: 284–290
Bansky G, Meier PJ, Ziegler WH (1985) Révérai of hepatic coma by benzodiazepin antagonist Ro 15–1788). Lancet 1: 1324–1325
Baraldi M, Zeneroli ML (1982) Experimental hepatic encephalopathy - changes in gammamino- butyric acid. Science 216: 427–431
Baraldi M, Caselgrandi E, Borella P, Zeneroli ML (1983a) Decrease of brain zinc in experimental hepatic encephalopathy. Brain Res 258: 170–172
Baraldi M, Zeneroli ML, Ricci P (1983b) Down regulation of striatal dopamine receptors in experimental hepatic encephalopathy. Life Sei 32: 1417–1425
Baraldi M, Zeneroli ML, Ventura E, Penne A, Pinelli G, Ricci P, Santi M (1984) Supersensitivity of benzodiazepine receptors in hepatic encephalopathy due to fulminant hepatic failure in the rat: reversal by a benzodiazepine antagonist Clin Science 67: 167–175
Bengtsson F (1987) Chronic portal-systemic encephalopathy. Thesis. Bulletin No. 66, Department of Surgery, Lund University, Lund Benjamin AM, Okamoto K, Quastel JH (1978) Effects of ammonium ions on spontaneous action potentials and on contents of sodium, potassium, assonium and chloride ions in brain in vitro. J Neurochem 30: 131–143
Bianchi-Porro G, Maiolo AT, Delia-Porto P (1969) Cerebral blood flow und metabolism before and after portacaval shunt operation. Gut 10: 894–897
Binder H (1981) Die neuropsychiatrische Symptomatik des sogenannten “Coma hepaticum”. Beilage zur Wiener Klinischen Wochenschrift 93: 3–19
Bircher J, Bührer M, Franz K, van Velthuijsen JA (1982) Erstmalige Anwendung von Lactitol in der Behandlung der porto-systemischen Enzephalopathie. Schweiz Med Wschr 112:1306— 1307
Bockel R, Doffoel M (1981) Lavage digestif au mannitol dans les hémorragies digestives du cirrhotique. Nouv Presse Med 10: 33–36
Brunner G, Scharff P (1978) Untersuchungen über den diagnostischen Wert der Bestimmung von Mercaptanen im Serum bei Lebererkrankungen. Dtsch Med Wschr 103: 1796–1800
Cangiano C, Cardelü-Cangiano P, James JH, Rossi-Fanelli F, Patrizi MA, Brackett KA, Strom R, Fischer JE (1983) Brain microvessels take up large neutral amino acids in exchange for glutamine. Cooperative role of Na*-dependent and Na+-independent systems. J Biol Chem 258: 8949–8954
Cardelli-Cangiano P, Cangiano C, James JH, Jeppsson B, Brenner W, Fischer JE (1981) Uptake of amino acids by brain microvessels isolated from rats after portacaval anastomosis. J Neuro-chem 36: 627–632
Cardelli-Cangiano P, Cangiano C, James JH, Ceci F, Fischer JE, Stiom R (1984) Effect of ammonia on amino acid uptake by brain microvessels. J Biol Chem 259: 5295–5300
Cerra FB, Cheung NK, Fischer JE (1985) Disease specific amino acid infusion (F080) in hepatic encephalopathy: a prospective, randomized, double-blind, controlled trial. J Parent and Ent Nutr 9: 228–295
Conn HO (1977) Trailmaking and number conncetion tests in the assessment of metal state in
postal systemic encephalopathy. Am J Dig Dis 22:541–550
Conn HO, Lieberthal MM (1979) The hepatic coma syndromes and lactulose. Williams amp; Wilkins, Baltimore Conn HO, Leevy CM, Vlahcevic ZR, Rodgers JB, Maddrey WC, Seeff L, Levy LL(1977) Comparison of lactulose and neomycin in the treatment of chronic portal-systemic encephalopathy. Gastroenterology 72: 573–583
Cooper AJL, Mora SN, Cruz NF, Gelbard AS (1985) Cerebral ammonia metabolism in hyper-ammonemic rats. J Neurochem 44: 1716–1723
Cruz NF, Duffy TE (1983) Local cerebral glucose metabolism in rats with portacaval shunts. J Cerebr. Blood Flow amp; Metabol 3: 311–320
Cuilleret G, Pomier-Layrargues G, Pons F, Cadilhac J, Michel H (1980) Changes in brain catecholamine levels in human cirrhotic hepatic encephalopathy. Gut 21: 565–569
Cummings MG, Soeters PB, James JH, Keane JM, Fischer JE (1976) Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat. J Neurochem 27: 501–509
De Bruijn KM, Blendis LM, Zilm DH, Carlen PL, Anderson GH (1983) Effect of dietary protein manipulations in subclinical portal-systemic encephalopathy. Gut 24: 53–60
Delorme ML, Denis J, Nordlinger B, Boschat M, Opolon P (1981) Relationship between plasma and brain tryptophan in pigs during experimental hepatic coma before and after hemodialysis with selective membranes. J Neurochem 36: 1058–1066
Ede RJ, Williams R (1986) Hepatic encephalopathy and cerebral edema. Sem in Liver Disease 6: 107–118
Egberts EH, Schomerus H, Hamster W, Jürgens P (1985) Branched chain amino acids in the treatment of latent portosystemic encephalopathy. Gastroenterology 88: 887–895
Elsass P, Christensen SE, Mortensen L, Vilstrup H (1985) Discrimination between organic and hepatic encephalopathy by means of continous reaction times. Liver 5: 29–34
Enna SJ, Wood JH, Snyder SH (1977) 7-Aminobutyric acid (GABA) in human cerebrospinal fluid: radioreceptor assay. J Neurochem 28: 1121–1124
Faraj BA, Bowen PA, Isaacs JW, Rudman D (1976) Hypertryraminemia in cirrhotic patients.N Engl J Med 294: 1360–1364
Ferenci P (1986) Critical evaluation of the role of branched chain amino acids in liver disease. In: Thomas JC, Jones EA (eds) Recent advances in heptalogy. Churchill Livingstone Edinburgh London Melbourne New York, pp 137–154
Ferenci P, Wewalka F (1978) Plasma amino acids in hepatic encephalopathy. J Neural Transmiss, Suppl 14: 87–94
Ferenci P, Dragosics B, Wewalka F (1981) Oral administration of branched chain amino acids (BCAA) and keto acids (BCKA) in patients with liver cirrhosis (LC). In: Walser M, Williamson JR (eds) Metabolism and clinical implications of branched chain amino acids and ketoacids, Elsevier/North Holland, New York Amsterdam-Oxford, pp 507–512
Ferenci P, Covfell D, Schafer DF, Waggoner JG, Shrager R, Jones EA (1983a) Metabolism of the inhibitory neurotransmitter 7-aminobutyric acid in a rabbit model of fulminant hepatic failure. Hepatology 3: 507–512
Ferenci P, Riederer P, Jellinger K, Schafer DF, Jones EA (1983b) Changes in 7-aminobutyric acid receptor in patients with hepatic encephalopathy. Gastroenterology 84: 1371
Ferenci P, Schäfer DF, Kleinberger G (1983c) Serum levels of gamma-aminobutyric acid–like activity in acute and chronic hepatocellular disease. Lancet 11: 811–814
Ferenci P, Jacobs R, Pappas SC, Schafer DF, Jones EA (1984a) Enzymes of cerebral GAB A metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity. J Neurochem 42: 1487–1490
Ferenci P, Pappas SC, Munson PJ (1984b) Changes in the status of neurotransmitter receptors in a rabbit model of hepatic encephalopathy. Hepatology 4: 186–191
Ferenci P, Pappas SC, Munson PJ, Jones EA (1984c) Changes in glutamate receptors on synaptic membranes associated with hepatic encephalopathy or hyperammonemia in the rabbit. Hepatology 4: 25–29
Ferenci P, Ebner J, Zimmermann CH, Roth E, Häussinger D (1986a) Is blood gamma-amino- butyric acid (GABA) increased in hepatic encephalopathy? Hepatology 6: 1157
Ferenci P, Jones EA, Hanbauer I (1986b) Lack of evidence for impaired dopamine receptor function in experimental hepatic encephalopathy. Neurosci Letters 65: 60–64
Ferenci P, Zieve L, Ebner J, Zimmermann CH, Rzepczynski D (1986c) Postsynaptic neural membrane affinity for GABA and receptor density are unaltered in hepatic coma following portacaval shunt (PCS) and hepatic artery ligation ( HAL ). Hepatology 6: 1157
Ferenci P, Zimmermann CH, Ebner J (1986d) Thioacetamide-induced acute liver failure in the rat - a suitable model for hepatic encephalopathy? J Hepatology 3, Suppl 1: 121
Fischer JE, Baldessarini RJ (1971) False neurotransmitters and hepatic failure. Lancet 2: 75–80
Fischer JE, Funovics J, Aguirre A, James JH, Keane JH, Wesdorf RIC, Yoshimura N, Westman T (1975) The role of plasma amino acids in hepatic encephalopathy. Surgery 78: 276–290
Goetcheus JS, Webster LT (1965) 7-Aminobutyrate and hepatic coma. J Lab Clin Med 65:257– 267
Gove CD, Ede RJ, Williams R (1984) In vivo reduction of Na+, K+-ATPase activity in rat brain during D-Galactosamine-induced acute hepatic failire: a possible cause of encephalopathy. In: Kleinberger G, Ferenci P, Riederer P, Thaler H (eds) Advances in hepatic encephalopathy and urea cycle diseases. Karger, Basel, pp 314–318
Greenberger NJ, Carley J, Schenker S, Bettinger I, Stamnes C, Beyer P (1977) Effect of vegetable and animal protein diets in chronic hepatic encephalopathy. Dig Dis 22: 845–855
Grippon P, Le Poncin-Laffite M, Boschat M, Wang S, Favre G, Dutertre D, Opolon P (1986) Evidence for the role of ammonia in the intracerebral transfer and metabolism of tryptophan. Hepatology 6: 682–686
Hawkes CH, Macpherson AJS, Pryor H, Townsend HRA (1970) The values of EEG frequency analysis in hepatic encephalopathy. J Roy Coll Surg (Edingburgh) 18: 151–156
Herlong GF, Maddrey WC, Walser M (1980) The use of ornithine salts of branched chain ketoacids in portal systemic encephalopathy. Ann Int Med 93: 545–550
Hindfelt B, Plum F, Duffy TE (1977) Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts. J Clin Invest 59: 386–396
Hirayama CH, Ichida F, Takahashi Y, Koizumi T, Sata S, Kosaka Y, Wakui K, Shimada Y, Yoshiba A, Hattori N, Ooya T, Takino T, Takeda H (1982) A controlled clinical trial of nicotino- hydroxamic acid and neomycin in advanced chronic liver disease. Digest 25: 115–123
Holm E, Krämer W, Reith HJ, Magin T, Mezitis NHE (1977) Electrophysiological and psychometric studies in hepatic encephalopathy. In: Varro V, Balint GA, Creutzferdt W (eds) Current Views in Gastroenterology, vol I, Budapest, pp 597–613
Horowitz ME, Schafer DF, Molnar P et al. (1983) Increased blood brain transfer in a rabbit model of acute liver failure. Gastroenterology 84: 1003–1011
Horst D, Grace ND, Conn HO et al. (1984) Comparison of dietary protein with an oral, branched chain-enriched amino acid supplement in chronic portal-systemic encephalopathy: a randomized controlled trial. Heptology 4: 279–287
Huet PM, Rocheleau B, Pomier-Layrargues G, Willems B (1984) Blood brain barrier in dogs with and without hepatic encephalopathy. In: Kleinberger G, Ferenci P, Riederer P, Thaler H (eds) Advances in hepatic encephalopathy and urea cycle diseases. Karger, Basel, pp 261–271
James JH, Escourrou J, Fischer JE (1978) Blood brain neutral amino acid transport activity is increased after portacaval anastomosis. Science 200: 1395–1397
James JH et al. (1979) Hyperammonemia, plasma amino acid imbalance and blood-brain amino acid transport: a unified theory of portal-systemic encephalopathy. Lanced ii: 772–775
Jones EA, Clain D, Clink HM, McGillivary M, Sherlock S (1967) Hepatic coma due to acute hepatic necrosis treated by exchange blood transfusions. Lancet 2: 169–171
Jonung T, Rigotti P, James JH, Brakcett K, Fischer JE (1985) Effect of hyperammonemia and methionine sulfoximine on the kinetic parameters of blood-brain transport of leucine and phenylalanine. J Neurochem 45: 308–317
Kienzl E, Riederer P, Jellinger K, Roth E, Ferenci P (1984) Modulation of serotonin receptors by L-value in hepatic encephalopathy. In: Schlossberger HG, Kochen W, Linzen B, Stein- hart H (eds) Progress in tryptophan and serotonin research. Walter de Gruyter amp; Co, Berlin New York, pp 333–337
Lanthier PL, Morgan MY (1985) Lactitol in the treatment of chronic hepatic encephalopathy: an open comparison with lactulose. Gut 26: 415–420
Laursen H, Westergaard E (1977) Enhanced permeability to horseradish peroxidase across cerebral vessels in the rat after portacaval anastomosis. Neuropath Appl Neurobiol 3: 29–34
Livingstone AS, Ptovin M, Goresky CA (1977) Changes in the blood brain barrier in hepatic coma after hepatectomy in the rat. Gastroenterology 73: 697–704
Lockwood AH, Ginsberg MD, Rhoades HM, Gutierrez MT (1986) Cerebral glucose metabolism after portacaval shunting in the rat. Pattern of metabolism and implications for the pathogenesis of hepatic encephalopathy. J of Clin Invest 78: 123–131
Maddison JE, Dodd PR, Johnston GAR, Farrell GC (1987) Brain GABA receptor binding is normal in rats with thioacetamide-induced hepatic encephalopathy despite elevated plasma GABA-like activity. Gastroenterology 93: 1062–1068
Mans AM, Biebuyck JF, Saunders SJ, Kirseh RE, Hawkins RA (1979) Tryptophan transport across the blood-brain barrier during acute hepatic failure. J Neurochem 33: 409–418
Mans AM, Biebuyck JF, Shelly K, Hawkins RA (1982) Regional blood-brain barrier permeability to amino acids after portacaval anastomosis. J Neurochem 38: 705–717
Mans AM, Biebuyck JF, Davis DW, Bryan RM, Hawkins RA (1983) Regional cerebral glucose utilization in rats with portacaval anastomosis. J Neurochem 40: 986–991
McClain CJ, Zieve L, Doizaki WM, Gilbertstadt S, Onstad GR (1980) Blood methanethiol in alcoholic liver disease with and without hepatic encephalopathy. Gut 21: 318–323
McGillivary BB (1975) The EEG in liver disease. In: Glaser GH (ed) Metabolic, endocrine and toxic disease. Handbook of electroencephalogy and clinical neurophysiology, vol 15, part C Elsevier, Amsterdam, pp 5–26
Mendenhall CL, Rouster S, Marshall L, Weesner R (1986) A new therapy for portal systemic encephalopathy. Amer J Gastroenterol 81: 540–543
Meryn S, Bauman WA, Pappas SC, Ferenci P, Jones EA (1986) Brain cholecystokinin and vasoactive intestinal polypeptide: immunoreactivity in rabbits with hepatic coma. Liver 6: 281–285
Michel H, Solere M, Grainer P (1980) Treatment of cirrhotic hepatic encephalopathy with L-Dopa: a controlled trial. Gastroenterology 79: 207–211
Minuk GY, Winder A, Gurgess ED, Saijeant EJ (1985) Serum Gamma-aminobutyric acid ( GABA) levels in patients with hepatic encephalopathy. Hepato-gastroenterol 32: 171–174
Morgan MY, Milson JP, Sherlock S (1978) Plasma ratio of valine, leucine and isoleucine to phenylalanine and tyrosine in liver disease. Gut 19: 1068–1075
Morgan M, Jakobovitzs AW, James M, Sherlock S (1980) Successful use of bromoeriptine in the treatment of hepatic encephalopathy. Gastroenterology 78: 663–670
M’oni F, Lombardi G, Moneti G, Cortesini C (1983) The release and neosynthesis of glutamic acid are increased in experimental models of hepatic encephalopathy. J Neurochem 40: 850–854
Moroni F, Riggio O, Carla V, Festuccia V, Ghinelli F, Varion IR, Merli M, Natali L, Pedretti G, Fiaccadori F, Capocaccia L (1987) Hepatic Encephalopathy: Lack of changes of 7-amino- butyric acid content in plasma and crebrospinal fluid. Hepatology 7: 816–820
Norenberg MD (1981) The astrocyte in liver disease. In: Fedoroff S, Hertz L (eds) Advances in cellular neurobiology, vol 2, Academic Press, pp 303–352
Ono J, Hutson DG, Dombro RS, Levi JU, Livingstone A, Zeppa R (1978) Tryptophan and hepatic coma. Gastroenterology 74: 196–200
Opolon P (1984) Significance of middle molecules in the pathogenesis of hepatic encephalopathy. In: Kleinberger G, Ferenci P, Riederer P, Tahler H (eds) Advances in hepatic encephalopathy and urea cycle disease. Karger Verlag, Basel, pp 310–313
Orlandi F, Freddara U. Candelaresi MT, Morettini A, Corazza GR, Di Simone A, Dobrilla G, Cavallini G (1981) Comparison between neomycin and lactulose in 173 patients with hepatic encephalopathy. Dig Dis Sci 26: 498–506
Pappas SC, Ferenci P, Jones EA (1983a) Evidence against the hypothesis that cerebral edema in fulminant failure is due to decreased neural Na+, K+ ATPase activity. Hepatology 3: 848
Pappas SC, Jones EA (1983b) Methods for assessing hepatic encephalopathy. Seminars in Liver Disease 3: 298–307
Pappas SC, Ferenci P, Schafer DF, Jones EA (1984a) Visual evoked potentials in a rabbit model of hepatic encephalopathy. II: Comparison of hyperamonemic encephalopathy, postictal coma, and coma induced by snyergistic neurotoxins. Gastroenterology 86: 546–551
Pappas SC, Ferenci P, Jones EA (1984b) Hepatic Encephalopathy: a disorder of synaptic, plasma membrane composition and fluidity? In Kleinberger G, Ferenci P, Riederer P, Thaler H (eds) Advances in hepatic encephalopathy and urea cycle diseases, Karger Verlag Basel, pp 331–336
Pappas SC, Levy GA, Gordon VP (1986) Decreased brain GABA binding in a model of fulminant hepatic failure (FHF): evidence conflicting with the GABA hypothesis for hepatic encephalopathy (HE). Hepatology 6:1106 Pardridge WH (1983) Brain metabolism: a perspective from the blood brain barrier. Physiol Rev 63: 1481–1535
Parsons-Smith BG, Summerskill WHJ, Dawson AM, Sherlock S (1957) The electroencephalograph in liver disease. Lancet 2: 867–871
Potvin M, Finlayson MH, Hinchey EJ, Lough JO, Goresky CA (1984) Cerebral abnormalities in hepatectomized rats with acute hepatic coma. Lab Invest 50: 560–564
Quarfoth G, Ahmed K, Zieve L (1976) Action of methane thiol on membrane Na+, K+-ATPase on rat brain. Biochem Pharmacol 25: 1039–1044
Raabe W, Gumnit RJ (1975) Dishinibition in cat motor cortex by ammonia. J Neurophysiol 38: 437–455
Rikkers L, Jenko P, Rudman D, Freides D (1978) Subclinical hepatic encephalopathy: Detection, prevalence and relationship to nitrogen metabolism. Gastroenterology 75: 462–469
Rudman D, Galambos JT, Smith RB, Salam AA, Warren WD (1973) Comparison of the effect of various amino aacids upon blood ammonia concentrations of patients with liver disease. Amer J Clin Nutr 26: 916–925
Rzepczynski D, Zieve L, Lindblat S, LaFontaine D (1986) In vivo studies of GABAergic effects in experimental hepatic encephalopathy. Hepatology 6: 902–905
Samson Y, Bernuau J (1987) Cerebral uptake of benzodiazepine measured by positron emission tomography in hepatic encephalopathy. New Engl J Med 316:414 Sarna GS, Bradbury MW, Cavanagh J (1977) Permeability of the blood brain barrier after portacaval anastomosis in the rat. Brain Res 138: 550–554
Sarna GS, Bradbury MWB, Cremer JE, Lai JCK, Teal HM (1979) Brain metabolism and specific transport at the blood brain barrier after portocaval anastomosis in the rat. Brain Res 160: 69–83
Schafer DF, Fowler JM, Jones EA (1981) Colonic Bacteria: a source of 7-aminobutyric acid in blood (41169). Proc Soc Exp Biol Med 167: 301–303
Schafer DF, Jones EA (1982) Hepatic encephalopathy and the 7-aminobutyric acid neurotransmitter system. Lancet 2: 18–19
Schafer DF, Fowler JM, Munson PJ (1983) Gamma-aminobutyric acid and benzodiazepin receptors in an animal model of fulminant hepatic failure. J Lab Clin Med 102: 870–880
Schafer DF, Pappas SC, Brady LE, Jacobs R, Jones EA (1984) Visual evoked potentials in a rabbit model of hepatic encephalopathy. I: Sequential changes and comparisons with drug induced comas. Gastroenterology 86: 540–545
Schalm SW, Van der Mey T (1979) Hyperammonemic coma after hepatectomy in germ-free rats. Gastroenterology 77: 231–234
Schomerus H, Hamster W, Blunck H, Reinhard U, Mayer K, Dolle W (1981) Latent portasystemic encephalopathy I. Nature of cerebral functional defects and fitness to drive. Dig Dis Sci 26: 622–630
Scollo-Lavizzari G, Steinman E (1985) Reversal of hepatic coma by benzodiazepin antagonist (Ro 15–1788). Lancet 1: 1324
Seda HWM, Hughes RD, Gove CD, Williams R (1984) Inhibition of rat brain Na+, K+-ATPase activity by serum from patients with fulminant hepatic failure. Hepatology 4: 74–79
Shaw S, Worner TM Lieber CS (1983) Comparison of animal and vegetable protein sources in the dietary management of hepatic encephalopathy. Amer J Clin Nutr 38: 59–63
Stahl J (1963) Studies of the blood amonia in liver disease. Its diagnostic, prognostic and therapeutic significance. Ann Int Med 58: 1–24
Tangerman A, Meuwese-Arends MT, Van Tongeren JHM (1983) A new sensitive assay for measuring volatile sulphur compounds in human breath by tenax trapping and gas chromatography and its application in liver cirrhosis. Clin Chim Acta 130: 103–110
Traber PG, Ganger DR, Blei AT (1986) Brain edema in rabbits with galactosamine induced fulminant hepatitis. Regional differences and effects on intracranial pressure. Gastroenterology 91: 1347–1356
Uribe M (1986) Optimized treatment options in portal systemic encephalopathy. Proc IASL Postgraduate course: Recent advances in hepatology, caracas Uribe M, Farca A, Marquez MA et al. (1979) Treatment of chronic portal systemic encephalopathy
with bromocriptine. Gastroenterology 76:1347–1351
Uribe M, Marquez MA, Gargaramos et al. (1980) Treatment of chronic portal systemic encephalopathy with lactose in lactase deficient patients. Dig Dis Sci 25: 914–928
Uribe M, Marquez MA, Ramos GG, Ramos-Uribe MH, Vargas F, Villalobos A, Ramos C (1982) Treatment of chronic portal-systemic encephalopathy with vegetable and animal protein diets. Dig Dis Sci 27: 1109–1116
Van der Ryt CCd, Schalm SW, De Groot GH, De Vlieger M (1984) Objective measurement of hepatic encephalopathy by means of automated EEG analysis. Electroencephalography and Clin Neurophysiology 57: 423–426
Weber FL, Veach GL (1979) The importance of the small intestine in gut ammonia production in germ free rats. Gastroenterology 77: 235–240
Weber FL, Minco D, Fresard KM, Banwell JG (1985) Effects of vegetable diets on nitrogen metabolism in cirrhotic subjects. Gastroenterology 89: 538–544
Windus-Podehl G, Lyftogt L, Zieve L (1983) Encephalopathic effect of phenol in rats. J Lab Clin Med 101: 586–592
Yang SS, Chu NS, Liaw YF (1985) Somatosensory evoked potentials in hepatic encephalopathy. Gastroenterology 89:625–630 Yang SS, Chu NS, Liaw YF (1986) Brainstem auditory evoked potentials in hepatic encephalopathy. Heptalogy 6: 1352–1355
Zaki AEO, Wardle EN, Canalese J et al. (1983) Potential toxins of acute liver failure and their
effects on blood-brain-barrier permeability. Experientia 39:988–991
Zaki AEO, Ede RJ, Davis M, Williams R (1984) Experimental studies of blood brain barrier permeabolity in acute hepatic failure. Hepatology 4: 359–363
Zeneroli ML, Iuliano E, Racagni G, Baraldi M (1982a) Metabolism and brain uptake of gamma- aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats. J Neurochem 38: 1219–1222
Zeneroli ML, Ventura E, Baraldi M, Penne A, Messori E, Zieve L (1982b) Visual evoked potentials in encephalopathy induced by galactosamine, ammonia, dimethyl, disulfied and octanoic acid. Hepatology 2: 532–538
Zeneroli ML, Pinelli G, Gollini G, Penne A, Messori E, Zani G, Ventura E (1984) Visual evoked potential: a diagnostic tool for the assessment of hepatic encephalpathy. Gut 25: 291–299
Zeneroli ML, Ventura E, Pinelli G, Casciarri I, Germini M, Cavalletti E, Tofanetti O, Baraldi M (1985) Opiate receptors and -endorphin levels in brain areas of dogs with portal-systemic encephalopathy. J Hepatol 1: 619–627
Zieve L, Olsen EL (1977) Can hepatic coma be caused by a reduction of brain noradrenaline or dopamine? Gut 18: 688–691
Zieve L, Doizaki WM, Zieve FJ (1974) Synergism between mercaptanes and ammonia or fatty acids in the production of coma: a possible role for mercaptanes in the pathogenesis of hepatic coma. J Lab Clin Med 83: 16–28
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Ferenci, P. (1998). Hepatische Enzephalopathie. In: Frick, P., von Harnack, GA., Kochsiek, K., Martini, G.A., Prader, A. (eds) Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics. Ergebnisse der Inneren Medizin und Kinderheilkunde/Advances in Internal Medicine and Pediatrics, vol 57. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73558-5_1
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