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Plasma Levels of Catecholamines and Dopamine-β-Hydroxylase

  • Chapter
Catecholamines II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 90 / 2))

Abstract

Shortly after Euler (1948) demonstrated that noradrenaline was the catecholamine present in mammalian sympathetic nerves, Peart (1949) showed that sympathetic nerve stimulation evoked release of this catecholamine into the effluent blood from a perfused bovine spleen. At that time, biological assays were used to assay the catecholamines present in extracts or in perfusates (Gaddum 1959), but generally these methods were inadequante for routine assay of levels of catecholamines normally found in plasma. It was not until the development of biochemical methods for assay that alterations in levels of human plasma catecholamines could be examined.

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  1. Department of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-8700, Würzburg, Germany

    U. Trendelenburg (Professor Dr.) (Professor Dr.)

  2. Department of Pharmacology, Colorado University, Medical Center, 4200 East Ninth Street, 80262, Denver, CO, USA

    N. Weiner (Professor Dr.) (Professor Dr.)

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Kopin, I.J. (1989). Plasma Levels of Catecholamines and Dopamine-β-Hydroxylase. In: Trendelenburg, U., Weiner, N. (eds) Catecholamines II. Handbook of Experimental Pharmacology, vol 90 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73551-6_6

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