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β-Phenylethylamine, Phenylethanolamine, Tyramine and Octopamine

  • Chapter
Catecholamines II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 90 / 2))

Abstract

Phenylethylamine derivatives (Fig. 1) were first synthesized and tested as sympathomimetic compounds (Barger and Dale 1910). Tyramine and octopamine were classified as indirectly acting sympathomimetic amines (Trendelenburg 1972). Octopamine was considered a “false” neurotransmitter, meaning that the amine was taken up, stored in, and released from catecholaminergic terminals upon nerve stimulation, but its release resulted in failure of transmission, since it exerted only a weak postsynaptic effect (Kopin 1968).

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  1. J. M. Saavedra
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  1. Department of Pharmacology and Toxicology, University of Würzburg, Versbacher Str. 9, D-8700, Würzburg, Germany

    U. Trendelenburg (Professor Dr.) (Professor Dr.)

  2. Department of Pharmacology, Colorado University, Medical Center, 4200 East Ninth Street, 80262, Denver, CO, USA

    N. Weiner (Professor Dr.) (Professor Dr.)

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Saavedra, J.M. (1989). β-Phenylethylamine, Phenylethanolamine, Tyramine and Octopamine. In: Trendelenburg, U., Weiner, N. (eds) Catecholamines II. Handbook of Experimental Pharmacology, vol 90 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73551-6_5

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