Abstract
Research on the neural function of catecholamines spans all levels of active investigation from the molecular to the behavioral. In this chapter we consider the behavioral actions of catecholamines and their related drugs in respect to the molecular actions, cellular structure, and the behavioral repertoire of central catecholamine neurons. Each of these aspects of central catecholamine neurons is an extensive independent body of research. However, we emphasize evidence for the relationships between the molecular level and the behavioral level. We first review those aspects of cellular structure and receptor mechanisms which are essential to an integrative assessment of function for the dopamine and noradrenaline systems. We next analyse the central dopaminergic neurons and the results of experimental perturbations on their actions, indicating the general gaps and overlaps in these studies. We conclude by considering the behavioral implications of the electrophysiological properties of noradrenergic neurons in awake, behaving animals in order to develop a basis on which to evaluate the behavioral effects of drugs and lesions which alter the function of the noradrenergic system.
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Bloom, F.E., Schulman, J.A., Koob, G.F. (1989). Catecholamines and Behavior. In: Trendelenburg, U., Weiner, N. (eds) Catecholamines II. Handbook of Experimental Pharmacology, vol 90 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73551-6_2
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