Abstract
Catecholamine biochemical genetics has advanced significantly during the past decade. Biochemical genetic studies have already contributed to our understanding of the regulation of catecholamine biosynthesis and metabolism and promise to help clarify the biological basis of individual variation of human adrenergic function. The most extensive catecholamine biochemical genetic data relate to the effects of inheritance on the enzymes that catalyze catecholamine biosynthesis and degradation. Before these data are reviewed, the research strategies and analytical techniques most commonly used in biochemical genetic experiments will be described briefly.
Supported in part by NIH grants NS 11014, HL 17487 and GM 28157. Dr. Weinshilboum is a Burroughs Wellcome Scholar in Clinical Pharmacology.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson RJ, Weinshilboum RM (1979) Phenolsulphotransferase: enzyme activity and endogenous inhibitors in the human erythrocyte. J Lab Clin Med 94: 158–171
Anderson RJ, Weinshilboum RM (1980) Phenolsulphotransferase in human tissue: radiochemical enzymatic assay and biochemical properties. Clin Chim Acta 103: 79–90
Anderson R, Weinshilboum R, Phillips S, Broughton D (1981) Human platelet phenol sulphotransferase: assay procedure, substrate and tissue correlations. Clin Chim Acta 110: 157–167
Assicot M, Bohuon C (1969) Production of antibodies to catechol-O-methyltransferase in rat liver. Biochem Pharmacol 18: 1893–1898
Assicot M, Bohuon C (1971) Presence of two distinct catechol-O-methyltransferase activities in red blood cells. Biochimie 53: 871–874
Axelrod J (1962) Purification and properties of phenylethanolamine N-methyl-transferase. J Biol Chem 237: 1657–1660
Axelrod J, Cohen CK (1971) Methyltransferase enzymes in red blood cells. J Pharmacol Exp Ther 176: 650–654
Axelrod J, Tomchick R (1958) Enzymatic O-methylation of epinephrine and other catechols. J Biol Chem 233: 702–705
Axelrod J, Vesell ES (1970) Heterogeneity of N- and O-methyltransferases. Mol Pharmacol 6: 78–84
Bailey DW (1971) Recombinant-inbred strains. Transplantation 11: 325–327
Baker H, Joh TH, Reis DJ (1980) Genetic control of the number of midbrain dopaminergic neurons in inbred strains of mice: relationship to size and neuronal density of the striatum. Proc Nat Acad Sci USA 77: 4369–4373
Baron M, Kreuz D, Levitt M, Gruen R, Asnis L (1982 a) Variation in thermal stability of human plasma dopamine-beta-hydroxylase. Biol Psychiat 17: 621–626
Baron M, Levitt M, Hunter C, Gruen R, Asnis L (1982 b) Thermolabile catechol-O- methyltransferase in human erythrocytes: a confirmatory note. Biol Psychiat 17: 265–270
Bateson W (1907) The progress of genetic research. In: Spottiswoode London, Report of the Third International Conference 1906 on Genetics, pp 90–97
Bellin JW, Sorrentino JM (1974) Kinetic characteristics of monoamine oxidase anserum Cholinesterase in several related rat strains. Biochem Genet 11: 309–317
Blaschko H (1974) The natural history of amine oxidases. Rev Physiol Biochem Pharmacol 70: 81–148
Breakefield XO, Castiglione CM, Edelstein SB (1976) Monoamine oxidase activity decreased in cells lacking hypoxanthine phosphoribosyltransferase activity. Science 192: 1018–1020
Breakefield XO, Edelstein SB, Castro Costa MR (1979) Genetic analysis of neurotransmitter metabolism in cell culture: studies on the Lesch-Nyhan syndrome. In Breakefield XO (Eds) Neurogenetics: Genetic Approaches to the Nervous System. Elsevier, New York, pp 197–234
Breakefield XO, Giller EL, Nürnberger JI, Castiglione CM, Buchsbaum MS, Gershon ES (1980) Monoamine oxidase type A in fibroblasts from patients with bipolar depressive illness. Psychiat Res 2: 307–314
Breakefield XO, Edelstein SB, Grossman MH (1981) Variations in MAO and NGF in cultured human skin fibroblasts. In: Gershon ES, Matthysse S, Breakefield XO, Ciaranello RD, (Eds) Genetic Strategies in Psychobiology and Psychiatry. Boxwood Press, Pacific Grove, pp 129–142
Bridge TP, Wise CD, Potkin SG, Phelps BH, Wyatt RJ (1981) Platelet monoamine oxidase: studies of activity and thermolability in a general population. In: Gershon ES, Matthysse S, Breakefield XO, Ciaranello RD (Eds), Genetic Strategies in Psychobiology and Psychiatry. Boxwood Press, Pacific Grove, pp 95–104
Bruell JH (1962) Dominance and segregation in the inheritance of quantitative behavior in mice. In: Bliss EL (Ed) Roots of Behavior. Harper and Brothers, New York pp 48–67
Castro Costa MR, Breakefield XO (1979) Electrophoretic characterization of monoamine oxidase by [3H]pargyline binding in rat hepatoma cells with A and B activity. Mol Pharmacol 16: 242–249
Castro Costa MR, Edelstein SB, Castiglione CM, Chao H, Breakefield XO (1980) Properties of monoamine oxidase in control and Lesch-Nyhan fibroblasts. Biochem Genet 18: 577–590
Cavalli-Sforza LL (1976) Enzyme polymorphism. Neurosci Res Prog Bull 14: 56–58
Cavalli-Sforza LL, Bodmer WF (1971) The Genetics of Human Populations. San Francisco: Freeman
Cavalli-Sforza LL, Santachiara SA, Wang L (1974) Electrophoretic study of 5-hydroxy- tryptophan decarboxylase from brain and liver in several species. J Neurochem 23: 629–634
Cawthon RM, Breakefield XO (1979) Differences in A and B forms of monoamine oxidase revealed by limited proteolysis and peptide mapping. Nature (Lond) 281: 692–694
Ciaranello RD (1978) Regulation of phenylethanolamine N-methyltransferase. Bio-chem Pharmacol 27: 1895–1897
Ciaranello RD, Axelrod J (1973) Genetically controlled alterations in the rate of degradation of phenylethanolamine N-methyltransferase. J Biol Chem 248: 5616–5623
Ciaranello RD, Barchas R, Kessler S, Barchas JD (1972 a) Catecholamines: strain differences in biosynthetic enzyme activity in mice. Life Sci 11: 565–572
Ciaranello RD, Dornbusch JN, Barchas JD (1972 b) Regulation of adrenal phenylethanolamine N-methyltransferase activity in three inbred mouse strains. Mol Pharmacol 8: 511–520
Ciaranello RD, Hoffman HF, Shire JGM, Axelrod J (1974) Genetic regulation of the catecholamine biosynthetic enzyme. II. Inheritance of tyrosine hydroxylase, dopa- mine-beta-hydroxylase and phenylethanolamine N-methyltransferase. J Biol Chem 249: 4528–4536
Committee on Nomenclature (1976) Report of Committee on Nomenclature. Birth Defects. Original Articles 12: 65–74
Conolly ME, Davies DS, Dollery CT, Morgan CD, Paterson JW, Sandler M (1972) Metabolism of isoprenaline in dog and man. Br J Pharmacol 46: 458–472
Creveling CR, Borchardt RT, Isersky C (1973) Immunological characterization of catechol-O-methyltransferase. In: Usdin E, Snyder S (Eds) Frontiers in Catecholamine Research Pergamon Press New York, pp 117–119
Dairman W, Christenson JG (1973) Properties of human red blood cell L-3,4-dihy-droxyphenylalanine decarboxylase activity. Eur J Pharmacol 22: 135–140
Dodgson KS (1977) Conjugation with sulfate. In: Parke DV, Smith RL (Eds) Drug Metabolism from Microbe to Man. Francis London, pp 91–104
Dunnette J, Weinshilboum R (1976) Human serum dopamine-beta-hydroxylase: correlation of enzymatic activity with immunoreactive protein in genetically defined samples. Am J Hum Genet 28: 155–166
Dunnette J, Weinshilboum R (1977) Inheritance of low immunoreactive human plasma dopamine-beta-hydroxylase: radioimmunoassay studies. J Clin Invest 60: 1080–1087
Dunnette J, Weinshilboum R (1979) Human plasma dopamine-beta-hydroxylase: variation in thermal stability. Mol Pharmacol 15: 649–660
Dunnette J, Weinshilboum R (1981) Human plasma dopamine-beta-hydroxylase: oxygen and thermal stability. Experientia 37: 115–117
Dunnette J, Weinshilboum R (1982 a) Family studies of plasma dopamine-beta-hydroxylase thermal stability. Am J Hum Genet 34: 84–99
Dunnette J, Weinshilboum R (1982 b) Serum dopamine-beta-hydroxylase activity in non-human primates. The Pharmacologist 24: 243
Dunnette J, Weinshilboum R (1983) Serum dopamine-beta-hydroxylase activity in non-human primates: phylogenetic and genetic implications. Comp Biochem Physiol 75: 85–91
Edelstein SB, Castiglione CM, Breakefield XO (1978) Monoamine oxidase activity in normal and Lesch-Nyhan fibroblasts. J Neurochem 31: 1247–1254
Elston RC, Stewart J (1971) A general model for the genetic analysis of pedigree data. Hum Heredity 21: 523–542
Elston RC, Namboodiri KK, Hames CG (1963) Segregation and linkage analysis of dopamine-beta-hydroxylase activity. Hum Heredity 29: 284–292
Falconer DS (1963) Quantitative inheritance. In: Burdette MJ (Ed) Methodology in Mammalian Genetics. Holden-Day, San Francisco, pp 193–216
Floderus Y, Wetterberg L (1981) The inheritance of human erythrocyte catechol-O-methyltransferase ( COMT) activity. Clin Genet 19: 392–395
Floderus Y, Ross SB, Wetterberg L (1981) Erythrocyte catechol-O-methyltransferase ( COMT) activity in a Swedish population. Clin Genet 19: 389–392
Freedman LS, Ohuchi T, Goldstein M, Axelrod F, Fish I, Dancis J (1972) Changes in human serum dopamine-beta-hydroxylase activity with age. Nature (Lond) 236: 310–311
Fuentes JA, Neff NH (1975) Selective monoamine oxidase inhibitor drugs as aids in evaluating the Role of type A and B enzymes. Neuropharmacol 14: 819–825
Gardner EJ (1984) Principles of Genetics. New York: John Wiley and Sons Gershon ES (1979) Genetics of the affective disorders. Hosp Pract 14: 117–122
Gershon ES, Jonas WZ (1975) Erythrocyte soluble catechol-O-methyltransferase activity in primary affective disorder. Arch Gen Psychiat 32: 1351–1356
Gershon ES, Jonas WZ (1976) Inherited differences in brain and erythrocyte soluble catechol-O-methyltransferase activity in two mouse strains. Biol Psychiat 11: 641–645
Gershon ES, Goldin LR, Lake CR, Murphy DL, Guroff JJ (1980) Genetics of plasma dopamine-beta-hydroxylase, erythrocyte catechol-O-methyltransferase and plasma monoamine oxidase in pedigrees of patients with affective disorders. In: Usdin E, Sourkes P, Youdim MBH (Eds) Enzymes and Neurotransmitters in Mental Disease. New York: Wiley and Sons pp 281–299
Goldin LR, Gershon ES, Lake CR, Murphy DL, McGinniss M, Sparkes RS (1982) Segregation and linkage studies of plasma dopamine-beta-hydroxylase (DBH), erythrocyte catechol-O-methyltransferase (COMT), and platelet monoamine oxidase (MAO): possible linkage between ABO locus and a gene controlling DBH activity. Am J Hum Genet 34: 250–262
Goldstein DJ, Weinshilboum RM, Dunnette JH, Creveling CR (1980) Developmental patterns of catechol-O-methyltransferase in genetically different rat strains: enzymatic and immunochemical studies. J Neurochem 34: 153–162
Groshong R, Gibson DA, Baldessarini RJ (1977) Monoamine oxidase activity in cultured human skin fibroblasts. Clin Chim Acta 80: 113–120
Grunhaus L, Ebstein R, Belmaker R, Sandler SG, Jonas W (1976) A twin study of human red blood pell catechol-O-methyltransferase. Br J Psychiat 128: 494–498
Harris H (1980) The Principles of Human Biochemical Genetics. Third edition. American Elsevier, New York
Hart RF, Renskers KJ, Nelson EB, Roth JA (1979) Localization and characterization of phenol sulfotransferase in human platelets. Life Sci 24:125–139
Heiss G, TyRoler HA, Gunnells JC, McGuffin WL, Harnes CG (1980) Dopamine-beta-hydroxylase in a biracial community: demographic, cardiovascular and familial factors. J Chron Dis 33: 301–310
Heston LL (1977) Schizophrenia: genetic factors. Hosp Pract 12: 43–49
Hodgetts RB (1975) The response of dopa decarboxylase activity to variations in gene dosage in Drosophila: a possible location of the structural gene. Genetics 79: 45–54
Hopkinson DA, Spencer N, Harris H (1964) Genetical studies on human red cell acid phosphatase. Hum Genet 16: 141–154
Houslay MD, Tipton KF, Youdim MBH (1976) Multiple forms of monoamine oxidase: fact and artifact. Life Sci 19: 467–478
Hum MMO, Friedhoff AJ (1979) Multiple molecular forms of catechol-O-methyl-transferase. J Biol Chem 254: 299–308
Johnson JP (1968) Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem Pharmacol 17: 1285–1297
Kessler S, Ciaranello RD, Shire JGM, Barchas JD (1972) Genetic variation in activity of enzymes involved in synthesis of catecholamines. Proc Nat Acad Sci USA 69: 2448–2450
Kimura M, Ohta T (1974) On some principles governing molecular evolution. Proc Nat Acad Sci USA 71: 2848–2852
Kuchel O, Buu NT, Unger T (1979) Free and conjugated dopamine; physiological and clinical implications. In Imbs JL, Schwartz J (Eds) Peripheral Dopaminergic Receptors. Pergamon Press, New York, pp 15–27
Kuchel O, Buu NT, Fontaine A, Harfiet P, Beroniade V, Larochelle P, Genet J (1980) Free and conjugated catecholamines in hypertensive patients with and without pheochromocytoma. Hypertension 2: 177–186
Levitt M, Mendlewicz J (1975) A genetic study of plasma dopamine-beta-hydroxylase in affective disorder. Mod Probl Pharmacopsychiat 10: 89–98
Levitt M, Spector S, Sjoerdsma A, Udenfriend S (1965) Elucidation of the rate limiting step in norepinephrine biosynthesis on the perfused guinea-pig heart. J Pharmacol Exp Ther 148: 1–8
Lewontin RC (1974) The Genetic Basis of Evolutionary Change. Columbia University Press.
Li CC (1961) Human Genetics, Principles and Methods. McGraw-Hill, New York
Maus TP, Pearson RK, Anderson RJ, Woodson LC, Reiter C, Weinshilboum RM (1982) Rat phenol sulfotransferase: assay procedure, developmental changes and glucocorticoid regulation. Biochem Pharmacol 31: 849–856
Mendel G (1865) Versuche über Pflanzen-Hybride. Verhandlungen des naturforschenden Vereines in Brünn 4: 3–47
Minamiura N, Yasumobu KT (1978) Bovine liver monoamine oxidase: a modified purification procedure and preliminary evidence for two subunits and one FAD. Arch Biochem Biophys 189: 481–489
Murphy DL (1978) Substrate-selective monoamine oxidases-inhibitor, tissue, species and functional differences. Biochem Pharmacol 27: 1889–1893
Murphy DL, Wright C, Buchsbaum M, Nichols A, Costa JL, Wyatt RJ (1976) Platelet and plasma amine oxidase activity in 680 normals: sex and age differences and stability over time. Biochem Med 16: 254–265
Murphy DL, Redmond DE Jr, Bauler J, Donnelly CH (1978) Platelet monoamine oxidase activity in 116 normal rhesus monkeys: relations between enzyme activity and age, sex, and genetic factors. Comp Biochem Physiol 60C: 105–108
Nies A, Robinson DS, Lamborn KR, Lampert RP (1973) Genetic control of platelet and plasma monoamine oxidase activity. Arch Gen Psychiat 28: 834–838
Ogihara T, Nugent CA, Shen SW, Goldfein S (1975) Serum dopamine-beta-hydroxylase activity in parents and children. J Lab Clin Med 85: 566–573
Paigen K (1971) The genetics of enzyme realization. In: Rechcigl M Jr (Ed) Enzyme Synthesis and Degradation in Mammalian Systems. University Park Press, Baltimore pp 1–44
Paigen K (1979) Acid hydrolases as model of genetic control. Ann Rev Genet 13: 417–466
Paigen K, Swank RT, Tomino S, Ganschow RE (1975) The molecular genetics of mammalian glucuronidase. J Cell Physiol 85: 379–392
Pandey GN, Doras E, Shaughnessy R, Davis JM (1979) Genetic control of platelet monoamine oxidase activity: studies on normal families. Life Sci 25: 1173–1178
Pintar JE, Barbosa J, Francke U, Castiglione CM, Hawkins MH Jr, Breakefield XO (1981) Gene for monoamine oxidase type A assigned to the human X chromosome. J Neurochem 1: 166–175
Quiram DR, Weinshilboum RM (1976) Catechol-O-methyltransferase in rat erythrocyte and three other tissues: comparison of biochemical properties after removal of inhibitory calcium. J Neurochem 27: 1197–1203
Raymond FA, Weinshilboum RM (1975) Microassay of human erythrocyte catechol-O- methyltransferase: removal of inhibitory calcium with chelating resin. Clin Chim Acta 58: 185–194
Reilly DK, Rivera-Calimlim L (1979) Racial difference in catechol-O-methyltransferase activity? A comparison of Filipinos with Caucasians in the United States. Clin Pharmacol Ther 25: 244
Reilly DK, Rivera-Calimlim L, Van Dyke D (1980) Catechol-O-methyltransferase activity: a determinant of levodopa response. Clin Pharmacol Ther 28: 278–286
Rein G, Glover V, Sandler M (1981) Phenolsulphotransferase in human tissue: evidence for multiple forms. In Sandler M, Usdin E (Eds) Phenolsulfotransferase in Mental Health Research MacMillan, London, pp 98–126
Reis DJ, Baker H, Fink JS, Joh TH (1981) A genetic control of the number of dopamine neurons in mouse brain: its relationship to brain morphology, chemistry and behavior. In: Genetic Strategies in Psychobiology and Psychiatry. Gershon ES, Matthysse S, Breakefield XO, Ciaranello RD (Eds) Boxwood Press, Pacific Grove, pp 215–229
Reiter C, Weinshilboum R (1982) Acetaminophen and phenol: substrates for both a thermostable and a thermolabile form of human platelet phenol sulfotransferase. J Pharmacol Exp Ther 221: 43–51
Renskers KJ, Feor KD, Roth JA (1980) Sulfation of dopamine and other biogenic amines by human brain phenol sulfotransferase. J Neurochem 34: 1362–1368
Roffman M, Reigle TG, Orsalak PJ, Schildkraut JJ (1976) Properties of catechol-O- methyltransferase in soluble and particulate preparations from rat red blood cells. Biochem Pharmacol 25: 208–209
Ross SB, Wetterberg L, Myrhed M (1973) Genetic control of plasma dopamine-beta-hydroxylase. Life Sci (I) 12: 529–532
Ross RA, Judd AB, Pickel VM, Joh TH, Reis DJ (1976) Strain-dependent variations in number of midbrain dopaminergic neurons. Nature (Lond) 264: 654–656
Roth JA, Breakefield XO, Castiglione CM (1976) Monoamine oxidase and catechol-O- methyltransferase activities in cultured human skin fibroblasts. Life Sci 19: 1705–1710
Sandler M, Youdim MBH, Harrington E (1974) A phenylethylamine oxidizing defect in migraine. Nature (Lond) 250: 335–337
Scanlon PD, Raymond FA, Weinshilboum RM (1979) Catechol-O-methyltransferase: thermolabile enzyme in erythrocytes of subjects homozygous for the allele for low activity. Science 203: 63–65
Schlesinger K, Harkins J, Deckard BS, Paden C (1975) Catechol-O-methyltransferase and monoamine oxidase activities in brains of mice susceptible and resistant to audiogenic seizures. J Neurobiol 6: 587–596
Seegmiller JE (1976) Inherited deficiency of hypoxanthine-guanine phosphoribosyl- transferase in X-linked uric aciduria (the Lesch-Nyhan syndrome and its variants). Advan Human Genet 6: 75–163
Sladek-Chelgren S, Weinshilboum RM (1981) Catechol-O-methyltransferase biochemical genetics. Biochem Genet 19: 1037–1053
Spielman RS, Weinshilboum RM (1979) Family studies of low red cell COMT activity. Am J Hum Genet 31:63 A
Spielman RS, Weinshilboum RM (1981) Genetics of red cell COMT activity: analysis of thermal stability and family data. Am J Med Genet 10: 279–290
Stolk JM, Hurst JH, Van Riper DA, Harris PQ (1979) Genetic analysis of serum dopamine-beta-hydroxylase activity in rats. Mol Pharmacol 16: 922–931
Swank RT, Bailey DW (1973) Recombinant inbred lines: value in the genetic analysis of biochemical variants. Science 181: 1249–1252
Tate SS, Sweet R, McDowell RH, Meister A (1971) Decrease of the 3,4-dihydroxy- phenylalanine ( DOPA) decarboxylase activities in human erythrocytes and mouse tissues after administration of DOPA. Proc Nat Acad Sci USA 68: 2121–2123
Tunnicliff G, Wimer CC, Wimer RE (1973) Relationships between neurotransmitter metabolism and behaviour in seven inbred strains of mice. Brain Res 61: 428–434
Vogel F, Motulsky AG (1979) Human Genetics, Problems and Approaches. Springer, New York
Wallace EF, Krantz MJ, Lovenberg W (1973) Dopamine-beta-hydroxylase: a tetrameric glycoprotein. Proc Nat Acad Sci USA 70: 2253–2255
Weinshilboum RM (1977) Serum dopamine-beta-hydroxylase activity and blood pressure. Mayo Clinic Proc 52: 374–378
Weinshilboum RM (1978 a) Human biochemical genetics of plasma dopamine-beta-hydroxylase and erythrocyte catechol-O-methyltransferase. Hum Genet Suppl I 101–112
Weinshilboum RM (1978 b) Human erythrocyte catechol-O-methyltransferase: correlation with lung and kidney activity. Life Sci 22:625–630
Weinshilboum RM (1978 c) Serum dopamine-beta-hydroxylase. Pharmacol Rev 30:133–166
Weinshilboum RM (1979 a) Genetic regulation of catechol-O-methyltransferase. Soc Neurosci Symp 4:67–82
Weinshilboum RM ( 1979 b) Catecholamine biochemical genetics in human populations. In: Breakefield XO (Ed) Neurogenetics: Genetic Approaches to the Nervous System. Elsevier, New York, pp 257–282
Weinshilboum RM (1981) Enzyme thermal stability and population genetic studies: application to erythrocyte catechol-O-methyltransferase and plasma dopamine- beta-hydroxylase. In: Gershon ES, Matthysse S, Breakefield XO, Ciaranello RD (Eds) Genetic Strategies in Psychobiology and Psychiatry. Boxwood Press Pacific Grove, pp 79–94
Weinshilboum R, Axelrod J (1971a) Serum dopamine-beta-hydroxylase. Cir Res 28: 307–315
Weinshilboum RM, Axelrod J (1971b) Reduced plasma dopamine-beta-hydroxylase activity in familial dysautonomia. New Engl J Med 285: 938–942
Weinshilboum RM, Raymond FA (1976) Calcium inhibition of rat liver catechol-O-methyltransferase. Biochem Pharmacol 25: 573–579
Weinshilboum RM, Raymond FA (1977 a) Inheritance of low erythrocyte catechol-O-methyltransferase activity in man. Am J Hum Genet 29: 125–135
Weinshilboum RM, Raymond FA (1977 b) Variations in catechol-O-methytransferase activity in inbred strains of rats. Neuropharmacol 16: 703–706
Weinshilboum RM, Raymond FA, Elveback LR, Weidman WH (1973) Serum dopamine-beta-hydroxylase activity: sibling-sibling correlation. Science 181: 943–945
Weinshilboum RM, Raymond FA, Elveback LR, Weidman WH (1974) Correlation of erythrocyte catechol-O-methyltransferase activity between siblings. Nature (Lond) 252: 490–491
Weinshilboum RM, Schrott HG, Raymond FA, Weidman WH, Elveback LR (1975) Inheritance of very low serum dopamine-beta-hydroxylase activity. Am J Hum Genet 27: 573–585
Weinshilboum RM, Dunnette J, Raymond F, Kleinberg F (1978) Erythrocyte catechol-O-methyltransferase and plasma dopamine-beta-hydroxylase in human umbilical cord blood. Experientia 34: 310–311
Weinshilboum RM, Raymond FA, Frohnauer M (1979) Monogenic inheritance of catechol-O-methyltransferase in the rat: biochemical and genetic studies. Biochem Pharmacol 28: 1239–1248
Wetterberg L, Book JA, Floderus Y, Ross SB (1979) Genetics and biochemistry of schizophrenia in a defined population. In: Usdin E, Kopin IJ, Barchas J (Eds) Catecholamines: Basic and Clinical Frontiers. Pergamon Press, New York, pp 1857–1859
Winter H, Herschel M, Propping P, Friedl W, Vogel F (1978) A twin study on three en-zymes (DBH, COMT, MAO) of catecholamine metabolism. Psychopharmacol 57: 63–69
Wise CD, Bridge P, Potkin SB, Wyatt RJ (1979) Platelet monoamine oxidase: studies on the rate of heat inactivation in normal and in paranoid and nonparanoid chronic schizophrenic groups. Psychiat Res 1: 187–190
Wurtman RJ, Axelrod J (1966) Control of enzymatic synthesis of adrenaline in the adrenal medulla by adrenal cortical steroids. J Biol Chem 241: 2301–2305
Wyatt RJ, Murphy DL, Belmaker R, Cohen S, Donnelly CH, Pollin W (1973) Reduced monoamine oxidase activity in platelets: a possible genetic marker for vulnerability to schizophrenia. Science 173: 916–918
Wyatt RJ, Potkin SG, Murphy DL (1979) Platelet monoamine oxidase activity in schizophrenia: a review of the data. Am J Psychiat 136:4A: 377–385
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Weinshilboum, R.M. (1989). Catecholamine Biochemical Genetics. In: Trendelenburg, U., Weiner, N. (eds) Catecholamines II. Handbook of Experimental Pharmacology, vol 90 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73551-6_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-73551-6_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73553-0
Online ISBN: 978-3-642-73551-6
eBook Packages: Springer Book Archive