Abstract
Chronic administration of potent long-acting luteinizing hormone-releasing hormone (LH-RH) agonists to patients in sufficiently high doses causes a chemical castration through suppression of the pituitary-gonadal axis. This therapy appears effective in the treatment of hormone-dependent tumors, such as breast and prostate cancer (for updated results, see the chapters in this volume).
This is a preview of subscription content, log in via an institution.
Preview
Unable to display preview. Download preview PDF.
References
Klijn JGM (1987) LH-RH agonists in the treatment of metastatic breast cancer: 5 years experience (this volume)
Eidne KA, Flanagan CA, Miller RP (1985) Gonadotropin-releasing hormone binding sites in human breast carcinoma. Science 229: 989–992
Miller WR, Scott WN, Morris R, Fraser HM, Sharpe RM (1985) Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist. Nature 313: 231–233
Miller WR, Scott WN, Fraser HM, Scharpe RM (1987) Direct inhibition of human breast cancer cell growth by an LH-RH agonist. In: Klijn JGM, Paridaens R, Foekens JA (eds)Proceedings of the International Symposium on Hormonal manipulation of cancer: peptides, growth factors and new (anti)steroidal agents, EORTC Monograph Series, Raven Press, New York Vol 18, pp 357–368
Sehally AV, Redding TW, Comaru-Schally AM (1984) Potential use of analogs of luteinizing hormone-releasing hormones in the treatments of hormone-sensitive neoplasms. Cancer Treat Rep 68: 281–289
Harvey HA, Lipton A, Max DT (1984) LH-RH analogs for human mammary carcinoma. In: Vickery BH, Nestor JJ, Hafex ESE (eds) LH-RH and its analogues, contraceptive and clinical application. MTP, Lancaster, pp 329–338
Harvey HA, Lipton A, Max D (1986) LH-RH agonist treatment of breast cancer: a phase II study in the USA. Eur J Cancer Clin Oncol 22: 724
Mathé G, Keiling R, Vovan ML, Gastiaburu J, Prévôt G, Vannetzel JM, Despax R, Jasmin C, Lévi F, Musset M, Machover D, Misset JL (1986) Phase II trial of D-Trp-6-LH-RH in advanced breast cancer. Eur J Cancer Clin Oncol 22: 723
Plowman PN, Nicholson RI, Walker KJ (1986) Remissions of metastatic breast cancer in postmenopausal women with luteinizing hormone releasing hormone (ICI 118630) therapy. Eur J Cancer Clin Oncol 22: 746
Waxman JH, Harland SJ, Coombes RC, Wrigley PFM, Malpas JS, Powles T, Lister TA (1985) The treatment of postmenopausal women with advanced breast cancer with buserelin. Cancer Chemother Pharmacol 15: 171–173
Klijn JGM, Foekens JA (1987) Long-term peptide hormone treatment with LH-RH-agonists in metastatic breast cancer. In: Santen R (ed) Proceedings of the International Symposium on Endocrine-dependent breast cancer: critical assessment of recent advances, 14th Int Congress, 23 Aug 1986, Budapest (in press)
Manni A, Santen R, Harvey H, Lipton A, Max D (1986) Treatment of breast cancer with gonadotropin releasing hormone. Endocr Rev 7: 89–94
Nicholson RI, Walker KJ, Turkes A, Dyas J, Plowman PN, Williams M, Elston CW, Blarney PW (1987) The British experience with LH-RH agonist Zoladex (ICI-118630) in the treatment of breast cancer. In: Klijn JGM, Paridaens R, Foekens J A (eds) Proceedings of the International Symposium on Hormonal manipulation of cancer: peptides, growth factors and new (anti)steroidal agents, EORTC Monograph Series, Raven Press, New York, Vol 18, pp 331–341
Nicholson RI, Walker KJ, Turkes A, Dyas J, Plowman PN, Williams M, Blarney RW (1985) Endocrinological and clinical aspects of LH-RH action (ICI-118630) in hormone dependent breast cancer. J Steroid Biochem 23: 843–844
Blankenstein MA, Henkelman MS, Klijn JGM (1983) An analogue of LH-RH antagonizes the growth-stimulation effect of oestradiol in human breast cancer cells in culture (MCF-7). J Steroid Biochem [Suppl] 19: 95S
Blankenstein MA, Henkelman MS, Klijn JGM (1985) Direct inhibitory effect of a luteinizing hormone-releasing hormone agonist on MCF-7 human breast cancer cells. Eur J Cancer Clin Oncol 21: 1493–1499
Foekens JA, Henkelman MS, Bolt-de Vries J, Portengen H, Fukkink JF, Blankenstein MA, van Steenbrugge GJ, Mulder E, Klijn JGM (1987) Direct effects of LH-RH analogs on breast and prostatic tumor cells. In: Klijn JGM, Paridaens R, Foekens JA (eds) Proceedings of the International Symposium on Hormonal manipulation of cancer: peptides, growth factors and new (anti)steroidal agents, EORTC Monograph Series, Raven Press, New York, Vol 18, pp 369–380
Foekens JA, Henkelman MS, Fukkink JF, Blankenstein MA, Klijn JGM (1986) Combined effects of buserelin, estradiol and tamoxifen on the growth of MCF-7 human breast cancer cells in vitro. Biochem Biophys Res Commun 140: 550–556
Klijn JGM, de Jong FH, Lamberts SWJ, Blankenstein MA (1985) LH-RH-agonist treatment in clinical and experimental human breast cancer. J Steroid Biochem 23: 867–873
Wiznitzer I, Benz C (1984) Direct growth inhibiting effects of the prolactin antagonists Buserelin and Pergolide on human breast cancer. Proc Am Assoc Cancer Res 25: 208
Schalley AV, Redding TW (1987) Use of LH-RH analogs for the treatment of prostate cancer: combination therapy and direct effects. In: Klijn JGM, Paridaens R, Foekens JA (eds) Proceedings of the International Symposium on Hormonal manipulation of cancer: peptides, growth factors and new (anti)steroidal agents, EORTC Monograph Series, Raven Press, New York (in press)
Besthois Y, Katzenellebogen JA, Katzenellebogen BS (1986) Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture. Proc Natl Acad Sci USA 83: 2496–2500
Klijn JGM, Setyono-Han B, Bakker GH, Henkelman MS, Foekens JA (1987) Inhibition of the growth of human breast cancer cells (MCF-7) in vitro and of DMB A tumors in vivo by an analog of somatostatin (Sandostatin): possible involvement of somatostatin receptors. In: Santen R (ed) Proceedings of the International Symposium on Endocrine-dependent breast cancer: critical assessment of recent advances, 14th Int Congress, 23 Aug 1986, Budapest (in press)
Klijn JGM, Setyono-Han B, Bakker GH, Henkelman MS, Portengen H, Foekens JA (1987) Effects of somatostatin analog (Sandostatin) treatment in experimental and human cancer. In: Klijn JGM, Paridaens R, Foekens JA (eds) Proceedings of the International Symposium on Hormonal manipulation of cancer: peptides, growth factors and new (anti)steroidal agents, EORTC Monograph Series, Raven Press, New York, Vol 18, pp 459–468
Setyono-Han B, Henkelman MS, Foekens JA, Klijn JGM (1987) Direct inhibitory effects of somatostatin (analogs) on the growth of human breast cancer cells. Cancer Res (in press)
Westley B, Rochefort H (1979) Estradiol induced proteins in the MCF-7 human breast cancer cell line. Biochem Biophys Res Commun 90: 410–416
Vignon F, Capony F, Chambon M, Freiss G, Garcia M, Rochefort H (1985) Estrogen-specific proteins released by breast cancer cells in culture and control of cell proliferation. In: Hollander, VP (ed) Hormonally responsive tumors. Academic Press, Orlando, Florida, pp 135–153
Dickson RB, Huff KK, Spencer EM, Lippman ME (1986) Induction of epidermal growth factor- related polypeptides by 17 (ß-estradiol in MCF-7 human breast cancer cells. Endocrinology 118: 138–142
Dickson RB, Bates SE, McManaway ME, Lippman ME (1986) Characterization of estrogen responsive transforming activity in human breast cancer cell lines. Cancer Res 46: 1707–1713
Lippman ME, Dickson RB, Bates S, Knabbe C, Huff K, Swain S, McManaway M, Bronzert D, Kasid A, Gelman EP (1986) Autocrine and paracrine growth regulation of human breast cancer. Breast Cancer Res Treat 7: 59–70
Horwitz KB, Koseki Y, McGuire WL (1978) Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen. Endocrinology 103: 1742–1751
Eckert RL, Katzenellebogen BS (1982) Effects of estrogens and anti-estrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells. Cancer Res 42: 139–144
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Foekens, J.A., Klijn, J.G.M. (1988). Direct Antitumor Effects of an LH-RH Agonist. In: Höffken, K. (eds) LH-RH Agonists in Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73530-1_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-73530-1_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73532-5
Online ISBN: 978-3-642-73530-1
eBook Packages: Springer Book Archive