Abstract
There has been little improvement in our ability to alter the course and survival of patients with chronic granulocytic leukemia (CGL) during the past 50 years. Many forms of treatment, such as busulfan, hydroxyurea, dibromomannitol, melphalan, mercaptopurine, thioguanine, and splenic irradiation, are effective in controlling the manifestations of CGL during the chronic phase, but none of these agents delays the onset of the blast phase or prolongs survival.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Galton DAG (1959) Treatment of the chronic leukemias. Br Med Bull 15: 78–85
Bergsagel DE (1967) The chronic leukemias: a review of disease manifestations and the aims of treatment. Can Med Assoc J 96: 1616–1620
Taetle R, Buick RN, McCulloch EA (1980) Effect of interferon on colony-formation in culture by blast cell progenitors in acute myeloblasts leukemia. Blood 56: 549–552
Talpaz M, McCredie KB, Mavlight GM, Gutterman JU (1983) Leukocyte interferon-induced myeloid cytoreduction in chronic myelogenous leukemia. Blood 62: 689–692
Talpaz M, Kantarjian HM, McCredie KB, Trujillio JM, Keating MJ, Gutterman JU (1986) Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha 2a in chronic myelogenous leukemia. N Engl J Med 314: 1065–1069
Samid D, Chang EH, Friedman RM (1984) Biochemical correlates of phenotypic reversion in interferon-treated mouse cells transformed by a human oncogene. Biochem Biophys Res Commun 119: 21–28
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Bergsagel, D.E. (1988). Maintenance Therapy of Busulfan-Induced Chronic Granulocytic Leukemia Remissions with Interferon-α2b . In: Huhn, D., Hellriegel, K.P., Niederle, N. (eds) Chronic Myelocytic Leukemia and Interferon. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73526-4_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-73526-4_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-19067-7
Online ISBN: 978-3-642-73526-4
eBook Packages: Springer Book Archive