Side Effects and Major Complications of Breast-Conserving Therapy

  • K. Engel
  • D. von Fournier
  • M. Kaufmann
  • F. Kubli
Conference paper

Abstract

The increasing degree of adaptation of the treatment administered in general for carcinoma to suit the individual needs of the patients means that in addition to primarily oncological aspects, the patients’ quality of life has become a major consideration. As long as the indications for breast-conserving therapy are strictly applied and its limitations are borne in mind, it is an alternative to mutilating amputation of the breast [23,44]. Breast-conserving therapy, however, has not yet been established as a routine procedure, and when it is performed it is important for doctor and patient alike to be aware of the possible complications and side effects.

Keywords

Neuropathy Fractionation Oncol Compressibility Lymphedema 

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References

  1. 1.
    Amberger H (1983) Die Behandlung des Stewart-Treves-Syndroms. (Treatment of Stewart-Treves syndrome). Chirurg 54, 487PubMedGoogle Scholar
  2. 2.
    Beadle GF, Come S, Henderson IC, Silver B, Hellman S, Harris JR (1984) The effect of adjuvant chemotherapy on the cosmetic results after primary radiation treatment for early stage breast cancer. Int J Radiat Oncol Biol Phys 10, 2131PubMedCrossRefGoogle Scholar
  3. 3.
    Bell HG (1949) Cancer of the breast. Ann Surg 130, 310CrossRefGoogle Scholar
  4. 4.
    Brismar B, Ljundgdahl I (1983) Postoperative lymphedema after treatment of breast cancer. Acta Chir. Scand. 149, 687Google Scholar
  5. 5.
    Britton RC, Nelson PA (1962) Causes and treatment of postmastectomy lymphedema of the arm. JAMA 180, 95PubMedGoogle Scholar
  6. 6.
    Budd DC, Cochran RC, Sturtz DL, et al. (1978) Surgical morbidity after mastectomy operations. Am J Surg 135, 218PubMedCrossRefGoogle Scholar
  7. 7.
    Calitchi E, Chaula JM, Otmezguine Y, Roucayrol AM, Mazeron JJ, Le Bourgeois JP, Pierquin B (1984) Analyse retrospective a 10 ans des sequelles du traitement loco- regional des cancers du seins. (10-year retrospective analysis of the sequelae of loco- regional treatment of breast cancer). Bull Cancer (Paris), 71 (2), 100Google Scholar
  8. 8.
    Clarke D, Martinez A, Cox RS (1982) Breast edema following staging axillary node dissection in patients with breast carcinoma treated by radical radiotherapy: Cancer 49, 2295PubMedGoogle Scholar
  9. 9.
    Chu AM, Cope O, Russo R, Wang CC, Schultz MD, Wang C, Rodkey G (1980) Treatment of early stage breast cancer by limited surgery and radical irradiation. Int J Radiat Oncol Biol Phys 6, 25–30PubMedGoogle Scholar
  10. 10.
    Daland EM (1950) The incidence of swollen arms after radical mastectomy and suggestions for prevention. N Engl J Med 242, 497CrossRefGoogle Scholar
  11. 11.
    Danoff BF, Goodman RL, Glick JH, Haller DG, Pajak Th T (1983) The effects of adjuvant chemotherapy on cosmesis and complications in patients with breast cancer treated by definitive irradiation. Int J Radiation Oncology Biol Phys 9, 1625Google Scholar
  12. 12.
    Feigenberg Z, Zer M, Dintsman M (1977) Comparison of postoperative complications following radical and modified radical mastectomy. World J Surg 1, 207CrossRefGoogle Scholar
  13. 13.
    Flew TJ (1979) Wound drainage following radical mastectomy: the effect of restriction of shoulder movement. Br J Surg 66, 302PubMedCrossRefGoogle Scholar
  14. 14.
    Foldi E, Foldi M (1986) Die Therapie chronischer GliedmaBenodeme. Z Allg Med 62, 955Google Scholar
  15. 15.
    Halsted WS (1921) Swelling of the arm after operations for cancer of the breast - elephantiasis chirurgica - its cause and prevention. Bull Johns Hopkins Hosp. 32, 309Google Scholar
  16. 16.
    Harris JR, Levene MB, Svenson G (1979) Analysis of cosmetic results following primary radiation therapy for stages I and II carcinoma of the breast. Int J Radiat Oncol Biol: Phys 5: 257Google Scholar
  17. 17.
    Harris JR, Hellman S (1982) Primary radiation therapy for early breast cancer: the experience at the Joint center for Radiation Therapy in Alternatives to Mastectomy, Harris JR, Hellman S, Silen W (Eds), Philadelphia, JB Lippincott CoGoogle Scholar
  18. 18.
    Healey JE jun (1971) Role of rehabilitation medicine in the care of the patient with breast cancer. Cancer 6, 1666Google Scholar
  19. 19.
    Ingianni G, Holzmann T (1985) Klinische Erfahrungen in der Anwendung von lym- pho-venösen Anastomosen beim sekundären Lymphödem Handchir Mikrochir Plast Chir 17, 43Google Scholar
  20. 20.
    Jolly P, Viar W (1981) Reduction of morbidity after radical mastectomy. Am Surg 47, 377PubMedGoogle Scholar
  21. 21.
    Kim JHI, Chu FCH, Hilaris B (1975) The influence of dose fractionation on acute and late reactions in patients with postoperative radiotherapy for carcinoma of the breast, Cancer, 35, 1583PubMedCrossRefGoogle Scholar
  22. 22.
    Kissin MW, della Rovere GQ, Easton D, Westbury G (1986) Risk of lympedema following the treatment of breast disease. Br J Surg 73, 580PubMedCrossRefGoogle Scholar
  23. 23.
    Kubli F, von Fournier D (1986) Brusterhaltende Therapie des Mammacarcinoms in Aktuelle Geburtshilfe und Gynäkologie, Melchert F, et al. (Eds) Springer Verlag Berlin, 280Google Scholar
  24. 24.
    Kuhnke E (1979) Methodik zur Volumenbestimmung menschlicher Extremitäten aus Umfangsmessungen. Physiotherapie 70, 251Google Scholar
  25. 25.
    Langlands AO, Souter WA, Samuel E (1977) Radiation osteitis following irradiation for breast cancer. Clin Radiol 28, 93PubMedCrossRefGoogle Scholar
  26. 26.
    Larson D, Weinstein M, Goldberg I, et al. (1986) Edema of the arm as a function of the extent of axillary surgery in patients with Stage I-II carcinoma of the breast treated with primary radiotherapy. Int J Radiat Oncol Biol Phys 12 (9), 1575PubMedCrossRefGoogle Scholar
  27. 27.
    Lichter AS (1982) the National Cancer Institute experience - primary radiotherapy and adjuvant chemotherapy. In Alternatives to Mastectomy, Harris JR, Hellman S, Silen W (Eds), Philadelphia, JB Lippincott CoGoogle Scholar
  28. 28.
    Lobb AW, Harkins HN (1949) Postmastectomy swelling of the arm with a note on the effect of segmental resection of the axillary vein at the time of radical mastectomy. West J Surg 57, 550PubMedGoogle Scholar
  29. 29.
    Match RM (1975) Radiation-induced brachial plexus paralysis. Arch Surg 110, 384PubMedGoogle Scholar
  30. 30.
    Montague ED (1968) Experience with altered fractionation in radiation therapy of breast cancer, Radiology, 90, 962PubMedGoogle Scholar
  31. 31.
    DeMoss EV, Lichter AS, Lippman ME, Gerber LG, Reichert CM, Edwards BK, Schain WS, Gorrell CR, d’Angelo TM, Rosenberg SA (1983) Complete axillary lymph node dissection before radiotherapy for primary breast cancer. In Conservative Management of Breast Cancer: New Surgical and Radiotherapeutic Techniques, Eds. Harris JR, Hellman S, Silen W (eds) London JB, Lippincott Co, pp 163–182Google Scholar
  32. 32.
    Pezner RD, Patterson MP, Hill LR, Lipsett JA, Desai KR, Vora N, Wong JY, Luk KH (1986) Arm lymphedema in patients treated conservatively for breast cancer: relationship to patient age and axillary node dissection technique. Int J Radiat Oncol Biol Phys 12 (12), 2079PubMedCrossRefGoogle Scholar
  33. 33.
    Pierquin B (1982) Conservative treatment for carcinoma of the breast - Experience of Creteil, 10 years’ results. In Alternatives to Mastectomy, Harris JR, Hellman S, Silen W (Eds) Philadelphia JB, Lippincott CoGoogle Scholar
  34. 34.
    Pollard R, Callum KG, Altman DG (1976) Shoulder movement following mastectomy. Ann Surg 133, 565Google Scholar
  35. 35.
    Ryttov N, Blichert-Toft M, Madjen EL (1983) Influence of adjuvant irradiation on shoulder joint function after mastectomy for breast cancer. Acta Radiol Oncol 22, 29PubMedCrossRefGoogle Scholar
  36. 36.
    Roberson PL, Lichter AS, Iler V (1983) Dose to lung in primary breast irradiation. Int J Radiat Oncol Biol Phys 9, 97PubMedCrossRefGoogle Scholar
  37. 37.
    Salner AL, Botnick LE, Herzog AG et al. (1981) Reversible brachial plexopathie following primary radiation therapy for breast cancer. Cancer Treat Rep 65: 797PubMedGoogle Scholar
  38. 38.
    Sapala JA, Sapala A, Soto AR, Sharpe D (1980) Lymphedema following modified radical mastectomy. Breast, 6 (4), 28Google Scholar
  39. 39.
    Say CC, Donegan W (1974) A biostatistical evaluation of complications from mastectomy. Surg Gynecol Obstet 138, 370PubMedGoogle Scholar
  40. 40.
    Stoll BA, Andrews JT (1966) Radiation-induced peripheral neuropathy. Br Med J 1, 834PubMedCrossRefGoogle Scholar
  41. 41.
    Swedborg I (1977) Voluminometric estimation of the degree of lymphedema. Scand J Rehabil Med 9, 131PubMedGoogle Scholar
  42. 42.
    Swedborg I, Wallgren A (1981) The effect of pre- and post-mastectomy radiotherapy on the degree of edema, shoulder joint mobility and gripping force. Cancer 47, 877PubMedCrossRefGoogle Scholar
  43. 43.
    Threefoot SA, Kossover MF (1966) Lymphaticovenous communications in man. Arch Int Med 117, 213CrossRefGoogle Scholar
  44. 44.
    Veronesi U, Saccozzi R, Del Vecchio M, Banti A, Demente C, De Lena M, Gallus G, Greco M, Luini A, Marubini E, Muscolino G, Rilke F, Salvadori B, Zecchini A, Zucali R (1981) Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Eng J Med 305, 6CrossRefGoogle Scholar
  45. 45.
    Veronesi U (1985) Randomized trials comparing conservation techniques with conventional surgery: An overview. In: Tobias JS, Peckham MJ (eds): Primary Management of Breast Cancer: Alternatives to Mastectomy Management of Malignant Disease Series, pp 131–152, London, E ArnoldGoogle Scholar
  46. 46.
    Yeah EK, Denham JW, Davies SA, Spittle MF (1986) Primary breast cancer, complications of axillary management. Acta Radiol (Oncol) 25, 105CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. Engel
  • D. von Fournier
  • M. Kaufmann
  • F. Kubli

There are no affiliations available

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