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Changes in Information Content with Physiological History in Peptidergic Secretory Systems

  • Conference paper
Book cover Stimulus-Secretion Coupling in Neuroendocrine Systems

Part of the book series: Current Topics in Neuroendocrinology ((CT NEUROENDOCRI,volume 9))

Abstract

This review seeks to focus attention on the potential complexity of the information conveyed by the release of chemicals during the synaptic or secretory activity of neurons. The importance of peptides in the control of neural function is underscored by the growing research in four different areas: (a) co-localization of peptides with classical neurotransmitters (Lundberg and Hökfelt 1983; Lloyd et al. 1987); (b) demonstration of peptidergic neurons in all parts of the central nervous systems of vertebrate and invertebrate species by immunohistochemical and biochemical approaches (e.g., Swanson and Sawchenko 1983; Siwicki et al. 1987; Kaldany et al. 1985); (c) cases of classical neurosecretory cells (e.g., those of the vertebrate hypothalamus, Swanson and Kuypers 1980) which do not have their processes restricted to neurohemal organs (e.g., the neurohypophysis), but participate in widespread interactions within the central nervous system; and (d) a spectrum of activities ranging from neurotransmitter to neurohormonal processes and their involvement in complex behaviors (Koob and Bloom 1982). Further, in all known instances, those neurons known to secrete peptides as either the major or a co-localized product never secrete a single peptide, but rather a mixture of peptides.

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Authors and Affiliations

  1. Békésy Laboratory of Neurobiology, University of Hawaii, Honolulu, Hawaii, 96822, USA

    R. W. Newcomb, D. K. Hartline & I. M. Cooke

Authors
  1. R. W. Newcomb
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  2. D. K. Hartline
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  3. I. M. Cooke
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Editor information

Editors and Affiliations

  1. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 6900, Heidelberg, Germany

    Detlev Ganten M.D., Ph.D.

  2. Rockefeller University, York Avenue, and 66th Street, New York, NY, 10021, USA

    Donald Pfaff Ph. D.

  3. Department of Anatomy, Medical School, Bristol, BS8 1TD, England, UK

    Brian Pickering Ph. D.

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© 1988 Springer-Verlag Berlin Heidelberg

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Newcomb, R.W., Hartline, D.K., Cooke, I.M. (1988). Changes in Information Content with Physiological History in Peptidergic Secretory Systems. In: Ganten, D., Pfaff, D., Pickering, B. (eds) Stimulus-Secretion Coupling in Neuroendocrine Systems. Current Topics in Neuroendocrinology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73495-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-73495-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73497-7

  • Online ISBN: 978-3-642-73495-3

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