Abstract
42 patients with testicular cancer and “bulky disease” were treated with a standardchemotherapy (BVP, 20 patients) or with a sequential alternating therapy-protocol (BVP/EIP, 22 patients). All patients received no prior chemotherapy.
With the standard-BVP-therapy 10 (50%) patients reached a CR, one patient is in PR/NED. The sequential alternating BVP/EIP-therapy resulted in 16 (73%) patients in a CR, 4 patients reached a PR/NED.
The median follow-up of the BVP-treated patients is 44 months, and 1 relapse occured; 10 (50%) patients are in CR. After a median follow-up of 21 months 4 relapses were observed in the BVP/EIP-treated patients group, 16 (73%) patients are in CR or in PR/NED.
The sequential alternating BVP/EIP-therapy seems to be superior to a standard-BVP-chemotherapy and might represent an attractive form of therapy in patients with testicular cancer and “bulky disease”.
Zusammenfassung
42 Patienten mit ausgedehnt metastasierten Hodentumoren (“bulky disease”) wurden entweder mit einem Standard-Chemotherapieprotokoll (BVP, 20 Patienten) oder sequentiell alternierend mit BVP/EIP (22 Patienten) behandelt. Alle Patienten waren chemotherapeutisch nicht vorbehandelt.
Mit der Standard-BVP-Therapie wurde bei 10 (50%) Patienten eine CR und bei einem eine PR/NED erzielt. Die sequentiell alternierende BVP/EIP-Therapie führte bei 16 (73%) Patienten zu einer CR, 4 Patienten erzielten eine PR/NED.
Das mediane follow-up der mit BVP-behandelten Patienten beträgt 44 Monate, wobei bisher 1 Rezidiv aufgetreten ist; derzeit befinden sich 10 (50%) Patienten in CR. Nach einer medianen Beobachtungszeit von 21 Monaten sind in der mit BVP/EIP behandelten Gruppe bisher 4 Rezidive aufgetreten, 16 (73%) Patienten befinden sich in CR oder PR/NED.
Die sequentiell alternierende BVP/EIP-Therapie scheint einer monophasischen BVP-Therapie überlegen zu sein und könnte bei Patienten mit Hodentumoren und “bulky disease” eine attraktive Form der Primärtherapie darstellen.
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Kuzmits, R., Ludwig, H., Aiginger, P. (1988). Vergleich einer Standard-Chemotherapie (BVP) mit einem sequentiell alternierenden Therapieprotokoll (BVP/EIP) bei Patienten mit Hodentumoren und weit fortgeschrittener Metastasierung (“Bulky Disease”). In: Schmoll, HJ., Weißbach, L. (eds) Diagnostik und Therapie von Hodentumoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73492-2_29
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DOI: https://doi.org/10.1007/978-3-642-73492-2_29
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