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Diagnostik und Therapie von Hodentumoren pp 125–135Cite as

Hat die impulszytophotometrische DNS-Bestimmung bei Hodentumoren prognostische Bedeutung?

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Abstract

The cellular DNA content of 111 malignant testicular germ cell tumors has been determined by flow cytometry. The following parameters were investigated: aneuploidy, heterogeneity, DNA index, and relative S-phase percentage. Aneuploidy is a good tumor marker, being found in 97.7% of cases. Heterogeneity was found in 19.6%. The modal value of the DNA index was around 3 c (triploidy).

None of these parameters is of importance for the prognosis of testicular cancer, in contrast to their prognostic value in many other solid tumors.

Zusammenfassung

An 111 malignen Hodentumoren wurden impulszytophotometrische Zellkern-DNS-Bestimmungen durchgeführt und die Parameter Aneuploidie, Heterogenität, DNA-Index und relativer S-Phase-Anteil untersucht. Die Aneuploidierate lag bei 97,7%, die Heterogenitätsrate bei 19,6%. Ferner zeigte sich eine Häufung der Tumorstammlinien um den dreifachen DNS-Gehalt (Triploidie).

Keinem der Parameter kommt jedoch beim Hodentumor im Gegensatz zu anderen soliden Tumoren prognostische Bedeutung zu.

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Authors
  1. G. Kleinhans
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  2. U. Hacker-Klom
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Editor information

Editors and Affiliations

  1. Abteilung Hämatologie/Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Deutschland

    Hans-Joachim Schmoll

  2. Urologische Abteilung, Krankenhaus am Urban, Dieffenbachstraße 1, 1000, Berlin 61, Deutschland

    Lothar Weißbach

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© 1988 Springer-Verlag Berlin Heidelberg

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Kleinhans, G., Hacker-Klom, U. (1988). Hat die impulszytophotometrische DNS-Bestimmung bei Hodentumoren prognostische Bedeutung?. In: Schmoll, HJ., Weißbach, L. (eds) Diagnostik und Therapie von Hodentumoren. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73492-2_15

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  • DOI: https://doi.org/10.1007/978-3-642-73492-2_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19039-4

  • Online ISBN: 978-3-642-73492-2

  • eBook Packages: Springer Book Archive

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